Orbital liposarcoma

Borbolla-Pertierra, A.M.; Morales-Baños, D.R.; Martínez-Nava, L.R.; Garrido-Sánchez, Gildardo Agustín; López-Hernández, C.M.; Velasco-Ramos, P.

doi:10.1016/j.oftale.2016.07.009

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…1,3,7,9–11,15,16,20 While ALT/WDL tumors make up 40% to 45% of liposarcomas, 21 the majority of liposarcomas involving the orbit were previously reported to be of the myxoid type (57%), followed by ALT/WDL (30%) and pleomorphic (11%). 1 However, upon the authors’ review of 63 documented cases of primary orbital liposarcoma in the English literature (including the authors’), 42.9% (n = 27) were ALT/WDL, 2–16 39.7% (n = 25) were myxoid, 1,7,13,20,22–33 8.9% (n = 6) were pleomorphic, 1,3,22,34–36 and 7.5% (n = 5) were dedifferentiated liposarcomas. 3,20,37–39 Excluding dedifferentiated cases, the breakdown was found to be 46.5% ALT/WDL, 43.1% myxoid, and 10.3% pleomorphic liposarcoma, suggesting that ALT/WDL is more common in the orbit than previously thought.…”

Section: Discussionmentioning

confidence: 98%

“…To date, there have been 24 cases (27, including the authors’) documented in the English literature with a diagnosis of ALT/WDL of the orbit. 1–16 In the authors’ review, 17 out of the 27 cases had utilized immunohistochemical staining to help confirm their diagnosis. 1,3,4,6,9–12,15,16 Two cases had utilized immunohistochemical staining for MDM2.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to surgical management, 6 of the patients received adjuvant radiation therapy. 2–4,7,8,14 Nine of the patients underwent local excision/debulking, with 5 patients experiencing recurrence, 3 without recurrence, and 1 lost to follow up. The authors’ patient in case 2 who did not have significant proptosis had opted for observation with serial MRIs and has been followed for up to 9 months without any significant changes.…”

Section: Discussionmentioning

confidence: 99%

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Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature

Kang

Kim

Wojno

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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The authors present 3 patients from this retrospective case series to review the clinical findings, imaging, pathology, and treatment of orbital atypical lipomatous tumor/well-differentiated liposarcoma. Pathology of biopsy specimens ranged from spindle cell proliferations mimicking neurofibroma to proliferations of well-differentiated adipocytes. Immunohistochemical stains were positive for murine double minute 2 in 1 case, and fluorescent in situ hybridization showed amplification of murine double minute 2 in 2 cases. Treatments ranged from serial debulking, proton beam irradiation, and exenteration. None of the patients developed metastases. A literature review supported the low-grade nature of this lesion. Orbital atypical lipomatous tumor/well-differentiated liposarcoma is a low-grade, indolent liposarcoma that may be locally invasive. The histologic diagnosis is enhanced with immunohistochemical staining for murine double minute 2 and fluorescent in situ hybridization analysis for amplification of murine double minute 2. Although treatment may vary according to the individual, conservative therapies may be attempted prior to radical surgery.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature

Kang

Kim

Wojno

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Typical locations include the retroperitoneum and extremities (up to 75% of cases) [1] , [3] . There are case reports of other rare locations: orbit [6] , oral cavity [7] , esophagus [8] , small bowel mesentery [9] , colon [10] , sigmoid mesentery [11] , pancreas [12] , scrotum [13] , and other areas.…”

Section: Discussionmentioning

confidence: 99%

Primary liposarcoma of the diaphragm: a rare intra-abdominal mass

Viragh¹,

Cherneykin

Oommen

et al. 2017

Radiology Case Reports

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“…While liposarcoma is the most common soft-tissue sarcoma in adulthood, in the orbit, this tumor is exceedingly rare, with only 70 reported cases to date. 1–27 In part due to its rarity, orbital liposarcoma remains a challenge to treat. Surgery is the mainstay of management; however, local recurrence is common and most patients eventually require exenteration.…”

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confidence: 99%

Orbital Liposarcoma: A Surveillance, Epidemiology and End Results Database Study

Chen,

Roelofs,

Baugh

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: Orbital liposarcoma is a challenging tumor to treat due to its rarity and high rate of local recurrence, and the role of radiotherapy and chemotherapy remain unclear. Analysis of big data may improve our overall understanding of orbital disease and role of adjuvant therapies. Methods: Data were extracted from the Surveillance, Epidemiology and End Results (SEER) Research Plus database from 1975 to 2017. All patients with a diagnosis of liposarcoma (ICD-O3 codes 8850-8858, 8869-8862, 8870, 8880, 8881) were included. Cases were divided into 4 groups by primary site: orbit, retroperitoneum, soft tissue, and other. Results: A total of 16,958 patients were included. Patients with orbital involvement were younger and more likely to be female (p < 0.05). Among orbital lesions, myxoid liposarcoma was the most common histologic subtype (6/19; 31.6%) followed by well differentiated (5/19; 26.3%). This differed from the distribution of histologic subtypes encountered elsewhere, for which well-differentiated liposarcoma was the most common (retroperitoneum 979/3,136; 31%, soft tissue 3,493/11,671; 30%, and other sites 497/2,132; 23%, p < 0.05). Dedifferentiated histologic subtype was the second most common subtype found in the retroperitoneum (946/3,136; 30%), whereas it was less common in the orbit (2/19; 11%) and soft tissue (1,396/11,671; 12%) (p < 0.001). Patients with orbital liposarcoma had similar disease-specific mortality compared with soft-tissue location (p = 0.825) and lower disease-specific mortality compared with retroperitoneal location (p < 0.001). When all locations were combined, patients with well-differentiated liposarcoma had the lowest disease-specific mortality. Conclusions: Patients with orbital liposarcoma tend to be younger, female, and have a better prognosis than those with retroperitoneal disease, likely due to the lower incidence of dedifferentiated histologic subtype.

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Orbital liposarcoma

Cited by 3 publications

References 11 publications

Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature

Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature

Primary liposarcoma of the diaphragm: a rare intra-abdominal mass

Orbital Liposarcoma: A Surveillance, Epidemiology and End Results Database Study

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