Orbital inflammation: Biopsy first

Mombaerts, Ilse; Rose, Geoffrey E.; Garrity, James A.

doi:10.1016/j.survophthal.2016.03.002

Cited by 95 publications

(85 citation statements)

References 53 publications

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“…Since low‐grade lymphoma and systemic diseases can mimic its clinical presentation, IOIS remains a diagnosis of exclusion, thereby justifying tissue biopsies when in doubt (Mombaerts et al. ). The 2017 IOIS pathological nomenclature suggests that two histological patterns predominate , namely a lymphoplasmacytic infiltrate or fibrous and/or hyalinized connective tissue (Mombaerts et al.…”

Section: Introductionmentioning

confidence: 99%

“…Idiopathic orbital inflammatory syndrome (IOIS), previously known as orbital pseudotumour, is a heterogeneous group of disorders characterized by orbital inflammation with no identifiable local or systemic cause (Jacobs & Galetta 2002;Yuen & Rubin 2003;Swamy et al 2007). Since low-grade lymphoma and systemic diseases can mimic its clinical presentation, IOIS remains a diagnosis of exclusion, thereby justifying tissue biopsies when in doubt (Mombaerts et al 2016). The 2017 IOIS pathological nomenclature suggests that two histological patterns predominate, namely a lymphoplasmacytic infiltrate or fibrous and/or hyalinized connective tissue (Mombaerts et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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IgG4‐related disease in patients with idiopathic orbital inflammation syndrome: data from the French SIOI prospective cohort

Abad

Martin

Héran³

et al. 2018

Acta Ophthalmologica

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Purpose To better characterize IgG4‐related disease (RD) in the setting of idiopathic orbital inflammation syndrome (IOIS). Methods National, multicentre, prospective, observational cohort study. Among the patients consecutively included in the French multicentre SIOI cohort, we selected those who underwent orbital and/or adnexal biopsy. Clinical, morphological and pathological findings at diagnosis were blindly analysed. Serum IgG4 levels at inclusion were measured and all available biopsy specimens were immunostained for IgG4 and IgG. Biopsy samples with more than 10 IgG4‐positive plasma cells per high‐power field and a IgG4+/IgG+ plasma cell ratio above 40% were scored as positive. IgG4‐positive patients were then screened for comprehensive diagnostic criteria for IgG4‐RD. Results Of the 87 patients included, 35 had histologically documented IOIS. Thirteen patients (37%) with a mean age at onset of 27 years (range 21–78) had IgG4‐positive biopsies, among which 10 patients (77%) and 3 (23%, with IgG4 serum levels >1.35 g/L) were considered as having probable and definite IgG4‐RD, respectively. The latter 13 patients more frequently fulfilled histological criteria for IgG4‐RD (including plasmacytic infiltrate (p = 0.006), fibrosis (p = 0.0025) and periphlebitis (p = 0.075)) than IgG4‐negative patients. Storiform fibrosis was exclusively found in orbital tissues from IgG4‐positive patients (n = 3, 23%). Eosinophilia associated with recurrent sinusitis or asthma was a prominent feature in patients with definite IgG4‐RD. Conclusions More than one‐third of patients with biopsy‐proven IOIS satisfied criteria for IgG4‐RD, but only a few had a definite type.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

IgG4‐related disease in patients with idiopathic orbital inflammation syndrome: data from the French SIOI prospective cohort

Abad

Martin

Héran³

et al. 2018

Acta Ophthalmologica

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“…Innymi metodami wspomagającymi postawienie rozpoznania są obserwacja wstępnej odpowiedzi na leczenie kortykosteroidami oraz biopsja tkanek oczodołu zajętych zapaleniem [29]. Klasycznie biopsję wykonuje się u pacjentów niereagujących na wstępne leczenie glikokortykosteroidami, w przypadkach nawracających lub postępujących [30]. W diagnostyce różnicowej należy brać pod uwagę: uraz z obecnością ciała obcego w obrębie oczodołu, infekcyjne zapalenie tkanek miękkich oczodołu, orbitopatię tarczycową, chłoniaki, przerzuty nowotworowe do oczodołu, ziarniniakowatość z zapaleniem naczyń i inne przyczyny zapaleń naczyń, oponiak nerwu wzrokowego, zespół Tolosy-Hunta [18,19,23].…”

Section: Rozpoznanieunclassified

Orbital Pseudotumor − Current State of Knowledge

2020

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The orbital pseudo-tumor is an orbital inflammatory disease of unknown origin that can affect all the anatomical structures that make up the orbit. The diagnosis is based on the assessment of clinical symptoms, imaging tests and the exclusion of other possible causes. Glucocorticosteroids are used for treatment, but other immunosuppressants as well as biological treatments can be used. The aim of the study is to present, based on the literature review, the current state of knowledge about pathogenesis, symptoms, differential diagnosis, and treatment of the orbital pseudotumor.

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“…Orbital biopsy is required in cases that do not respond appropriately, demonstrate progression or recurrence despite corticosteroid treatment. [ 23 ]…”

Section: The Role Of Orbital Biopsy In Idiopathic Orbital Inflammatiomentioning

confidence: 99%

Idiopathic orbital inflammation: Review of literature and new advances

Yeşiltaş

Gündüz

2018

Middle East Afr J Ophthalmol

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Idiopathic orbital inflammation (IOI) is a benign inflammatory condition usually confined to the orbit but extraorbital extension can also occur. IOI has been classified into categories including anterior, diffuse, posterior or apical, myositis, and dacryoadenitis. Other rare types of IOI include periscleritis, perineuritis, and focal mass. Diagnosis is based on careful history, clinical findings, computed tomography, and magnetic resonance imaging findings. An orbital biopsy is usually done for accessible orbital lesions such as dacryoadenitis. For other types such as myositis and apical IOI where surgery is difficult or dangerous, orbital biopsy is not initially considered. The mainstay of therapy consists of systemic corticosteroids, but other options including external beam radiotherapy, antimetabolites, alkylating agents, T-cell/calcineurin inhibitors, lymphocyte inhibitors, tumor necrosis factor-α inhibitors, and surgical debulking have also been used.

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Orbital inflammation: Biopsy first

Cited by 95 publications

References 53 publications

IgG4‐related disease in patients with idiopathic orbital inflammation syndrome: data from the French SIOI prospective cohort

IgG4‐related disease in patients with idiopathic orbital inflammation syndrome: data from the French SIOI prospective cohort

Orbital Pseudotumor − Current State of Knowledge

Idiopathic orbital inflammation: Review of literature and new advances

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