Orbital<i>Apergillosis</i>Treated with Retrobulbar Amphotericin B

Mainville, Norman; Jordan, David R.

doi:10.3109/01676830.2011.603596

Cited by 25 publications

(18 citation statements)

References 8 publications

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“…The lipid complex and liposomal form of amphotericin are alternative drugs used in cases with impaired renal function. Recently, retrobulbar amphotericin injection has been used for orbital aspergillosis [21,22]. Hyperbaric oxygen therapy has been sporadically used in IFS [23,24].…”

Section: Discussionmentioning

confidence: 99%

Invasive Fungal Sinusitis of the Sphenoid Sinus

Lee

Yoon

Lee

et al. 2014

Clin Exp Otorhinolaryngol

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ObjectiveThis study was conducted to present the clinical outcome of invasive fungal sinusitis of the sphenoid sinus and to analyze clinical factors influencing patient survival.MethodsA retrospective review of 12 cases of invasive fungal sphenoiditis was conducted.ResultsCases were divided into acute fulminant invasive fungal spheonoidits (n=4) and chronic invasive fungal sphenoiditis (n=8). The most common underlying disease was diabetes mellitus (n=9). The most common presenting symptoms and signs included visual disturbance (100%). Intracranial extension was observed in 8 patients. Endoscopic debridement and intravenous antifungals were given to all patients. Fatal aneurysmal rupture of the internal carotid artery occurred suddenly in two patients. The mortality rate was 100% for patients with acute fulminant invasive fungal sphenoiditis and 25% for patients with chronic invasive fungal sphenoiditis. In survival analysis, intracranial extension was evaluated as a statistically significant factor (P=0.027).ConclusionThe survival rate of chronic invasive fungal sphenoiditis was 75%. However, the prognosis of acute fulminant invasive fungal sphenoiditis was extremely poor despite the application of aggressive treatment, thus, a high index of suspicion should be required and new diagnostic markers need to be developed for early diagnosis of invasive fungal sinusitis of the sphenoid sinus.

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Section: Discussionmentioning

confidence: 99%

Invasive Fungal Sinusitis of the Sphenoid Sinus

Lee

Yoon

Lee

et al. 2014

Clin Exp Otorhinolaryngol

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“…[ 1 73 ] There has been one report of good response to intralesional amphotericin B used in isolation, without limited debridement or exenteration. [ 74 ]…”

Section: Investigationsmentioning

confidence: 99%

Fungal infections of the orbit

Mukherjee

Raichura

Alam

2016

Indian J Ophthalmol

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Fungal infections of the orbit can lead to grave complications. Although the primary site of inoculation of the infective organism is frequently the sinuses, the patients can initially present to the ophthalmologist with ocular signs and symptoms. Due to its varied and nonspecific clinical features, especially in the early stages, patients are frequently misdiagnosed and even treated with steroids which worsen the situation leading to dire consequences. Ophthalmologists should be familiar with the clinical spectrum of disease and the variable presentation of this infection, as early diagnosis and rapid institution of appropriate therapy are crucial elements in the management of this invasive sino-orbital infection. In this review, relevant clinical, microbiological, and imaging findings are discussed along with the current consensus on local and systemic management. We review the recent literature and provide a comprehensive analysis. In the immunocompromised, as well as in healthy patients, a high index of suspicion must be maintained as delay in diagnosis of fungal pathology may lead to disfiguring morbidity or even mortality. Obtaining adequate diagnostic material for pathological and microbiological examination is critical. Newer methods of therapy, particularly oral voriconazole and topical amphotericin B, may be beneficial in selected patients.

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“…[1] Intra-lesional amphotericin has also shown to be effective. [5] In this case, being reported local excision with amphotericin B irrigation and oral itraconazole for two months (being continued) has controlled the infection. This case is being highlighted for the variable presentation (precipitation by FESS) and the need to keep this condition in differential diagnosis of orbital mass since delay in treatment is potentially harmful.…”

Section: Case Reportmentioning

confidence: 88%