Orbital granulocytic sarcoma and AML with poor prognosis in Turkish children

Gözdaşoĝlu, Sevgi; Yavuz, Gülsan; Ünal, Emel; Taçyldz, N; Çavdar, Ayhan O.

doi:10.1038/sj.leu.2402449

Cited by 18 publications

(17 citation statements)

References 7 publications

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“…Our results of improved survival in patients with orbital myeloid sarcoma are in contrast to a Turkish study which found that children with AML and orbital granulocytic sarcoma had a very poor outcome with a mean survival time of 8.7 months (9). Another study though, of children with orbital granulocytic sarcoma had similar results to ours, with all 9 of these patients surviving their disease (10).…”

Section: Discussioncontrasting

confidence: 99%

Superior outcome of pediatric acute myeloid leukemia patients with orbital and CNS myeloid sarcoma: A report from the Children's Oncology Group

Johnston

Alonzo

Gerbing

et al. 2011

Pediatric Blood & Cancer

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Background Extramedullary leukemia (EML) is common in pediatric acute myeloid leukemia (AML) and occurs as leukemia cells within the cerebrospinal fluid (CSF) or as a solid tumor (myeloid sarcoma-MS). The effect of MS on survival is unknown. Methods Patients on CCG protocols 2861, 2891, 2941 and 2961 being treated for AML with intensive-timing chemotherapy were classified for the presence of EML (CSF leukemia, CNS-MS, orbital-MS, or non-CNS MS). CSF leukemia was classified as CNS 3 (≥5 wbc in the CSF with blasts) and non-CSF leukemia as CNS1/2 (<5 wbc in the CSF with or without blasts). Characteristics and outcomes of these patients were compared. Results Of the 1459 total patients, 1206(82%) had no EML, 154(11%) had CSF leukemia, 19(1%) had CNS-MS, 23(2%) had orbital-MS, and 57(4%) had non-CNS MS. The CR rate was significantly higher in patients with orbital-MS and CNS-MS than in those with non-MS and non-CNS MS (96% and 95% vs 78% and 78%,p=0.034). Patients with orbital-MS and CNS-MS had significantly higher overall survival than patients with non-CNS MS (92% and 73% vs 38%,p<0.001), CNS3 patients (92% and 73% vs 51,p<0.001), and CNS1/2 patients (92% and 73% vs 50%,p<0.001). Patients with orbital-MS had a significantly lower relapse rate. Conclusion Patients with myeloid sarcoma involving orbital and CNS sites had a significantly better survival than patients with non-CNS MS, with CSF leukemia, or with no extramedullary leukemia.

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Section: Discussioncontrasting

confidence: 99%

Superior outcome of pediatric acute myeloid leukemia patients with orbital and CNS myeloid sarcoma: A report from the Children's Oncology Group

Johnston

Alonzo

Gerbing

et al. 2011

Pediatric Blood & Cancer

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“…The mean survival was 28.6 months in AML cases without GS even though they received a similar chemotherapy protocol. The survival rate in GS has been improved with the approach of intensive chemoradiotherapy treatment modalities since 1990 [18]. When GS is associated with AML, …”

Section: Immunophenotyping Study Of Biopsy Materials Is Very Importantmentioning

confidence: 99%

Extramedullary Orbital Granulocytic Sarcoma Without Bone Marrow Involvement: A Report of Two Cases

Işık

Tavil

Tunç

et al. 2010

Pediatric Hematology and Oncology

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The authors present herein 2 extramedullary orbital granulocytic sarcoma (GS) cases without bone marrow involvement in view of their rarity and also to reevaluate the treatment approach in this disease. Seven days of high-dose methyl prednisolone (HDMP) treatment (3 days 30 mg/kg/day and 4 days 20 mg/kg/day) was administered initially, and subsequently Acute Myeloid Leukaemia-Berlin Frankfurt Münster (AML-BFM) 2004 treatment protocol was continued for 2 cases. Eye findings of the cases resolved considerably with HDMP treatment. They have still been under systemic chemotherapy without any complication for 1 year. Thus, early diagnosis and AML-targeted intensive chemotherapy improve the prognosis of GS even if there is no bone marrow involvement.

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“…Leukemia has symptoms such as anorexia, fatigue, irritability, mild fever, bone or joint pain, pallor, bleeding from the nose, anemia, thrombocytopenia, neutropenia and skin rash and may be associated with lymphadenopathy and splenomegaly (Kaspers et al, 2007;Chao et al, 2013;Gözdaşoğlu et al, 2002). The depression resulted from the disease and its treatment, sleep disorders, pain and cognitive changes are some abnormalities which affect these patients (Kaleyias et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Sleep Quality and Associated Risk Factors in Leukemia Patients Undergoing Chemotherapy in Iran

Bagheri-Nesami

Goudarzian²,

Babaei³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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This study aimed to determine sleep disorders and associated risk factors in leukemia patients undergoing chemotherapy in Imam Khomeini Hospital of Sari, Iran. This cross-sectional study was conducted in 2015 with 100 patients selected. Inclusion criteria included complete mental and psychological health and being over 18 years old, and exclusion criteria included suffering other cancers, other chronic diseases, concurrent radiotherapy, and chemotherapy. The Pittsburgh Sleep Quality standard questionnaire was used to collect data. The questionnaire consisted of mental sleep quality, sleep latency, sleep duration, sleep quality, sleep disturbances, use of sleeping drugs, and impaired daily functioning. Data were analyzed by software SPSS 18 and by using descriptive and inferential tests (Pearson, Spearman, T-test and chi-square). Totals of 47 men (47%) and 53 women (53%) with a mean age of 44.1±1.7, participated in the study. The mean overall score of sleep quality was 9.3±3.9, which represents the average sleep quality in most participants. T-test shows that males have better sleep quality than females (t=2.1; 95%CI:0.004-0.25; P<0.01). Also the sleep quality increased with age (r=0.22, P=0.03). Results show that the amount of sleep quality was only moderate in most patients, so it is necessary to take coping strategies to improve their quality of sleep.

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Orbital granulocytic sarcoma and AML with poor prognosis in Turkish children

Cited by 18 publications

References 7 publications

Superior outcome of pediatric acute myeloid leukemia patients with orbital and CNS myeloid sarcoma: A report from the Children's Oncology Group

Superior outcome of pediatric acute myeloid leukemia patients with orbital and CNS myeloid sarcoma: A report from the Children's Oncology Group

Extramedullary Orbital Granulocytic Sarcoma Without Bone Marrow Involvement: A Report of Two Cases

Sleep Quality and Associated Risk Factors in Leukemia Patients Undergoing Chemotherapy in Iran

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