Orbital giant cell angiofibroma: immunohistochemistry and differential diagnosis

Farmer, James; Lamba, Manisha; McDonald, Hector; Commons, A S

doi:10.1139/i06-002

Cited by 15 publications

(10 citation statements)

References 9 publications

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“…Up to the present time, only 70 cases have been reported to represent orbital HPC, orbital GCA, or orbital SFT [8,13,14,[23][24][25][26][27][28][29][30][31][32][33][34]. To our knowledge, this study reports the largest series reclassified as orbital SFT.…”

Section: Discussionmentioning

confidence: 68%

Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases

et al. 2011

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Section: Discussionmentioning

confidence: 68%

Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases

et al. 2011

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“…Immunohistochemical stains were positive for vimentin, CD34, acid mucopolysaccharides, and focally for CD68 (and factor XIIIa), but were negative for S100 and SMA. The differential diagnoses comprised of conjunctival (cellular) myxoma, 5 neurothekeoma, 3 subconjunctival herniated orbital fat, 7 fat-free spindle cell lipoma, 2 pseudotumor, neurofibroma, 8 dendrocytoma, 13 nevus with neuronal degeneration, 14 solitary fibrous tumor, 11 fibrous histiocytoma, 1, 6, 9 nodular fasciitis, 14 hemangiopericytoma, 4 giant cell angiofibroma, 10 and rhabdomyosarcoma. 12 Our benign conjunctival lesions were differentiated from these entities by cytologic and immunohistochemical features.…”

Section: Discussionmentioning

confidence: 99%

“…19 However, these neoplasms can be distinguished from our lesions by their morphologic growth patterns and cytologic features. In particular, giant cell angiofibroma can occur in the orbit 10, 20, 21 and is composed of spindle cells with pseudonuclear inclusions and giant cells with occasional florets. However, these tumors are usually more cellular and exhibit a high vascular density with vascular-like spaces that allows for a distinction from the described lesions herein.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Stromal Tumor: Report of 4 Cases

2012

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Purpose To describe the clinical, histopathologic, immunohistochemical, and ultrastructural features of a case series of benign stromal tumors in the bulbar conjunctiva. Design Observational case series. Participants Four patients with a conjunctival lesion that were classified histologically as low grade stromal tumors consisting of spindle-shaped cells with occasional pseudonuclear inclusion and multinucleated cells in a partly myxoid matrix. Methods Four cases of low grade conjunctival stromal tumors were retrospectively identified in an ophthalmic pathology laboratory database. Patients’ records were analyzed for demographic data, clinical appearance and the post-operative course. Formalin-fixed paraffin-embedded specimens were routinely processed and stained with hematoxylin and eosin (H&E) and periodic acid Schiff (PAS). Immunohistochemical stains for vimentin, S100, CD34, SMA (smooth muscle actin), CD68, and factor XIIIa were performed. Transmission electron microscopy (TEM) was performed on three of the cases. Main Outcome Measures Histopathologic evaluation (including immunostains and TEM) and clinical correlation. Results All four tumors occurred in the bulbar conjunctiva of patients between 41 to 53 years of age. None of the patients developed recurrence after excisional biopsy. Histologically, all tumors exhibited spindle-shaped cells with pseudonuclear inclusions and occasional multinuclear cells. Mitotic figures were not observed. The stroma appeared myxoid to collagenous. Immunohistochemical stains were positive for CD34, vimentin, and focally for CD68, but were negative for S100 and SMA. Conclusions We propose to classify these benign lesions which share distinct histopathologic features as “conjunctival stromal tumor (COST)”. A reactive/inflammatory component needs to be considered in the pathogenesis of this lesion.

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“…A controversial finding was the unexpected positivity of CD31 in the majority of cells compared to previous reports [7,21]. Clinically, this immunohistochemical finding may be interpreted by the more vascular nature of the tumor and it may provide a tool for differential diagnosis of GCA from SFT in the future.…”

Section: Discussionmentioning

confidence: 84%

“…The immunohistochemical features of GCA include positive staining for CD34, CD99, vimentin, variable bcl2 and negative staining for CD31, CD68, c-kit/CD117, muscle specific actin, S100, desmin [7,21]. …”

Section: Discussionmentioning

confidence: 99%

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature

Zhang

Liu

et al. 2014

World J Surg Onc

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PurposeTo present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA).Case presentationIn this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformation for one year prior to surgical removal. We summarize the clinical manifestations, imaging, pathological and molecular features of this rare disease.After complete surgical removal of the tumor, immunohistochemical analysis revealed strong positivity for the mesenchymal markers vimentin, CD34, CD31 and CD99 in neoplastic cells. Tumor proliferation antigen marker Ki67 was partly positive (<5% of cells). Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8. The morphological and immunohistochemical profile was consistent with the diagnosis of GCA.ConclusionGCA is a rare soft tissue tumor that can easily be misdiagnosed in the clinical preoperative setting. In view of the clinical, pathological and molecular features of the tumor, complete surgical removal is the current optimal treatment option, providing accurate diagnosis and low to minimal recurrence rate.

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Orbital giant cell angiofibroma: immunohistochemistry and differential diagnosis

Cited by 15 publications

References 9 publications

Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases

Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases

Conjunctival Stromal Tumor: Report of 4 Cases

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature

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