Orbital Angular Momentum Density of a Hollow Vortex Gaussian Beam

Zhou, Yimin; Zhou, Guoquan

doi:10.2528/pierm14060601

Cited by 13 publications

(13 citation statements)

References 28 publications

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“…2 CAPH + S• → CAPSSCAP + 2H + (5) In this case mechanism (4) is the rate-determining step for CAPSH oxidation. The overall oxidation reaction mechanism is similar to other reports [8,23,[30][31][32], with one electron and one proton responsible in dimerization of captopril to form disulfide.…”

Section: Methods Optimizationsupporting

confidence: 85%

Simple Real-time Voltammetric Method for Captopril Determination in Pharmaceutical Formulation

Buleandră¹,

Ciucu²,

Stefanescu³

2018

Rev. Chim.

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A novel voltammetric assay for captopril (CAP) determination by using an electrochemically pretreated pencil graphite electrode (PGE*) is presented. The electrochemical oxidation reaction of CAP was investigated with PGE* by using cyclic voltammetry and linear sweep voltammetry techniques. CAP was electrochemically inactive at the non-pretreated pencil graphite electrode surface, while a sharp anodic wave with an anodic peak potential at around 200 mV resulted by using the PGE*. According to kinetic studies upon the electrode behavior, a new reaction mechanism for electrochemical oxidation of captopril is proposed. The sensor was examined as a selective, simple and precise new electrochemical disposable electrode for the determination of CAP in pharmaceutical samples in complex medical cases associated with sleep apnea, with good results.

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Section: Methods Optimizationsupporting

confidence: 85%

Simple Real-time Voltammetric Method for Captopril Determination in Pharmaceutical Formulation

Buleandră¹,

Ciucu²,

Stefanescu³

2018

Rev. Chim.

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“…[24][25][26] Surface-induced dissociation (SID) has emerged as a powerful collision-based activation method for probing protein complex structures in the gas phase, yielding fragmentation that provides information complementary to that gained from the activation methods mentioned previously. 27 Rather than subjecting ions to multiple low-energy collisions with background gas, SID experiments direct ions into an inert, rigid surface to impart energy into the analyte in a single, high-energy step. SID generally results in a more symmetric partitioning of charge in the produced subcomplexes relative to CID 28 and UVPD.…”

Section: Introductionmentioning

confidence: 99%

“…[32][33][34] Until recently, work involving SID of protein complexes has largely been carried out on TOF platforms. 35,36 With growing utilization of native MS for structural characterization of protein complexes, it has become apparent that greater mass resolution is often desirable and allows for a deeper insight into a given biological system. For example, measurement of mass shifts resulting from post-translational modifications and/or the binding of small ligands or cofactors becomes possible at the protein complex level at sufficient resolution.…”

Section: Introductionmentioning

confidence: 99%

“…Herein, we present a combination of surface-induced dissociation and high-resolution mass analysis as applied to the study of protein complexes. An Exactive™ Plus Extended Mass Range (EMR) Orbitrap instrument (Thermo Fisher Scientific, Bremen, Germany), modified with a high-mass quadrupole filter, was fitted with an SID device inspired by previous designs described in works by Wysocki et al 35,36 As with previous designs, the new device enables the instrument to perform SID experiments without interrupting the capability or performance of MS-only and CID experiments. The SID-Orbitrap platform was tested using several protein complexes with known quaternary structure.…”

Section: Introductionmentioning

confidence: 99%

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Surface-Induced Dissociation of Noncovalent Protein Complexes in an Extended Mass Range Orbitrap Mass Spectrometer

et al. 2019

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Native mass spectrometry continues to develop as a significant complement to traditional structural biology techniques. Within native MS, surface-induced dissociation (SID) has been shown to be a powerful activation method for the study of non-covalent complexes of biological significance. High-resolution mass spectrometers have become increasingly adapted to the analysis of high-mass ions and have demonstrated their importance in understanding how small mass changes can affect the overall structure of large biomolecular complexes. Herein we demonstrate the first adaptation of surface-induced dissociation in a modified high-mass range, high-resolution Orbitrap mass spectrometer. The SID device was designed to be installed in the Q-Exactive series of Orbitrap mass spectrometers with minimal disruption of standard functions. The performance of the SID-Orbitrap instrument has been demonstrated with several protein complex and ligand-bound protein complex systems ranging from 53 to 336 kDa. We also address the effect of ion source temperature on native protein-ligand complex ions as assessed by SID. Results are consistent with previous findings on quadrupole time-of-flight instruments and suggest that SID coupled to high-resolution MS is well-suited to provide information on the interface interactions within protein complexes and ligand-bound protein complexes.

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“…12 The analytical instrumentation for detection of compounds in exhaled breath, EBC, and EBA has also improved to include GC-MS, LC-MS, Direct MS, and a variety of sensors, including electronic noses. 13,14,15,16 These detection methods have been utilized to advance research in human health and disease, including alcohol breath testing, 17,18 lung cancer, 19,20 asthma, 21,22 and chronic obstructive pulmonary disorder (COPD), 22,23,24 as well as to identify biomarkers of health state in breath matrices. These topics are discussed in this review within the context of the history of breath research from 1995-2016.…”

Section: Introductionmentioning

confidence: 99%

Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols

Wallace

Pleil

2018

Analytica Chimica Acta

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Human breath, along with urine and blood, has long been one of the three major biological media for assessing human health and environmental exposure. In fact, the detection of odor on human breath, as described by Hippocrates in 400 BC, is considered the first analytical health assessment tool. Although less common in comparison to contemporary bio-fluids analyses, breath has become an attractive diagnostic medium as sampling is non-invasive, unlimited in timing and volume, and does not require clinical personnel. Exhaled breath, exhaled breath condensate (EBC), and exhaled breath aerosol (EBA) are different types of breath matrices used to assess human health and disease state. Over the past 20 years, breath research has made many advances in assessing health state, overcoming many of its initial challenges related to sampling and analysis. The wide variety of sampling techniques and collection devices that have been developed for these media are discussed herein. The different types of sensors and mass spectrometry instruments currently available for breath analysis are evaluated as well as emerging breath research topics, such as cytokines, security and airport surveillance, cellular respiration, and canine olfaction.

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Orbital Angular Momentum Density of a Hollow Vortex Gaussian Beam

Cited by 13 publications

References 28 publications

Simple Real-time Voltammetric Method for Captopril Determination in Pharmaceutical Formulation

Simple Real-time Voltammetric Method for Captopril Determination in Pharmaceutical Formulation

Surface-Induced Dissociation of Noncovalent Protein Complexes in an Extended Mass Range Orbitrap Mass Spectrometer

Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols

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