Orange juice intake during a fatty meal consumption reduces the postprandial low-grade inflammatory response in healthy subjects

Cerletti, Chiara; Gianfagna, Francesco; Tamburrelli, Chiara; Curtis, Amalia De; D’Imperio, Marco; Coletta, Walter; Giordano, Lucia; Lorenzet, Roberto; Rapisarda, Paolo; Recupero, Giuseppe Reforgiato; Rotilio, Domenico; Iacoviello, Licia; Gaetano, Giovanni de; Donati, Maria Benedetta

doi:10.1016/j.thromres.2014.11.038

Cited by 29 publications

(18 citation statements)

References 29 publications

(31 reference statements)

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“…Myeloperoxidase has also been shown to be an inflammatory marker in coronary heart disease [24]. A postprandial increase in white blood cell and platelet counts and a decrease in the release of myeloperoxidase from polymorphonuclear leukocyte has previously been observed [27]. In our study, we also observed a decreased Myeloperoxidase level in the postprandial period.…”

Section: Resultssupporting

confidence: 85%

Effect of food intake on 92 biomarkers for cardiovascular disease

et al. 2017

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ObjectiveThe present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD).MethodsTwenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit.ResultsThe levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4–30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake.ConclusionsThis study shows that food intake affects several different CVD biomarkers, but the effect is predominantly modest. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Further studies are warranted in older healthy subjects and in patients with various cardiac diseases to determine whether the findings are reproducible.

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Section: Resultssupporting

confidence: 85%

Effect of food intake on 92 biomarkers for cardiovascular disease

et al. 2017

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“…Adherence to the Mediterranean diet was associated with an increase in adiponectin concentrations that may partially explain the beneficial effects of this traditional healthy diet on the cardiovascular system . An intervention study in apparently healthy subjects has shown that the concomitant intake of orange juice, which is rich in polyphenols, may prevent the low grade inflammatory reaction induced by a fatty meal, at cellular and possibly at vascular function levels . The same study group has also demonstrated that cellular responses to a fatty meal, in particular platelet P‐selectin expression and neutrophil generation and leucocyte degranulation, were attenuated in subjects at a higher degree of cardiovascular risk, who had not suffered any cardiovascular event .…”

Section: The Moli‐sani Studymentioning

confidence: 99%

Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI‐SANI study

Bonaccio

Pounis

Cerletti

et al. 2016

Brit J Clinical Pharma

168

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Low grade inflammation is characterized by raised concentrations of inflammatory markers in the absence of any overt symptoms and is recognized as a risk factor for a number of chronic diseases including cancer, cardiovascular, cerebrovascular and neurodegenerative diseases. Many studies suggest that low grade inflammation is mitigated by health promoting behaviours such as healthy eating patterns, physical activity, body weight maintenance and tobacco cessation. To date, large scale studies were mainly focused on circulating markers and little evidence is available on cellular biomarkers. The MOLI-SANI study is a prospective cohort study that has recruited 24 325 men and women aged ≥35 years from the general population of the Molise Region, a Southern Italian area, with the purpose of investigating genetic and environmental risk/protection factors for cardiovascular and cerebrovascular disease and cancer. Within this cohort, a composite score of low grade inflammation based on the use of plasmatic (C-reactive protein) and cellular (leukocyte and platelet counts and granulocyte : lymphocyte ratio) biomarkers has been proposed and validated. This score accounts for all possible synergistic effects of such inflammatory markers, thus overcoming any potential bias linked to the multi-collinearity of these variables. Of notice, the MOLI-SANI study was the first to address the relationship between the traditional Mediterranean diet and platelet and leucocyte counts as emerging cellular biomarkers of low grade inflammation. The present review paper will discuss the main findings derived from the MOLI-SANI study on the association of low grade inflammation with a Mediterranean eating pattern, with a particular emphasis on the associated dietary polyphenols.

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“…Second, it may be quite difficult to show any significant decrease in biochemical parameters that are only marginally altered before the treatment. In our previous experience on other nutraceuticals, we had observed a measurable effect of these compounds only in 'stressed' conditions, such as challenging healthy volunteers with a fatty meal, that induces an acute increase in inflammatory reactions (27) . We cannot exclude that the inclusion in the present study of patients with a more severe form of NAFLD could have produced more apparent results.…”

Section: Discussionmentioning

confidence: 99%

Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease

et al. 2019

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A mixture of natural ingredients, namely, DHA, phosphatidylcholine, silymarin, choline, curcumin and d-α-tocopherol, was studied in subjects with non-alcoholic fatty liver disease (NAFLD). Primary endpoints were serum levels of hepatic enzymes, and other parameters of liver function, the metabolic syndrome and inflammation were the secondary endpoints. The coagulation–fibrinolysis balance was also thoroughly investigated, as NAFLD is associated with haemostatic alterations, which might contribute to increased cardiovascular risk of this condition. The present study involved a double-blind, randomised, multicentre controlled trial of two parallel groups. Subjects with NAFLD (18–80 years, either sex) received the active or control treatment for 3 months. All assays were performed on a total of 113 subjects before and at the end of supplementation. The hepatic enzymes aspartate aminotransferase (AST), alanine aminotransferase and γ-glutamyl transpeptidase decreased from 23·2 to 3·7 % after treatment, only the AST levels reaching statistical significance. However, no differences were found between control and active groups. Metabolic and inflammatory variables were unchanged, except for a slight (less than 10 %) increase in cholesterol and glucose levels after the active treatment. Coagulation–fibrinolytic parameters were unaffected by either treatment. In conclusion, chronic supplementation with the mixture of dietary compounds was well tolerated and apparently safe in NAFLD subjects. The trial failed to demonstrate any efficacy on relevant physiopathological markers, but its protocol and results may be useful to design future studies with natural compounds.

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Orange juice intake during a fatty meal consumption reduces the postprandial low-grade inflammatory response in healthy subjects

Cited by 29 publications

References 29 publications

Effect of food intake on 92 biomarkers for cardiovascular disease

Effect of food intake on 92 biomarkers for cardiovascular disease

Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI‐SANI study

Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease

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