Orally Disintegrating Films Containing Propolis: Properties and Release Profile

Borges, Josiane Gonçalves; Carvalho, Rosemary Aparecida de

doi:10.1002/jps.24355

Cited by 39 publications

(27 citation statements)

References 61 publications

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“…These properties are inherent to the formulation but are also significantly influenced by the manufacturing process. 19) Physical strength is one of the most evident CQAs. The product should have suitable mechanical properties for easy manufacturing, packaging, and handling and minimal damage.…”

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Formulation Optimization and <i>in Vitro</i> Characterization of Orally Disintegrating Films Using a Factorial Design and Mathematical Modeling for Drug Release

Lee

Thapa

Jeong

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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Even though experimental designs are becoming popular especially for conventional dosage forms, limited studies have been performed to optimize formulations of orally disintegrating films (ODFs). This study aimed to evaluate sildenafil citrate-loaded ODFs for a controlled release with hydroxypropyl methylcellulose as a film-forming polymer. A factorial design was utilized for optimization with three control factors: ethanol ratio, plasticizer ratio, and the type of plasticizer. Tensile strength, disintegration time, water contact angle, and thickness were chosen as responses. For optimization, water contact angle, disintegration time, and thickness were minimized, while the tensile strength was maximized. Based on the conditions, optimal formulations were achieved for each type of plasticizer. Evaluation of desirability indicated that the response values were close to the target. When these optimal formulations were validated, the optimal solutions and target values were similar with small biases. The formulations were characterized using scanning electron microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy, surface pH, in vitro dissolution, and drug release simulation with a mathematical modeling. After the drug was homogenously dispersed throughout the film, the crystalline form of the drug provided strong hydrogen bonds between the drug and the film components. Moreover, it showed a controlled drug release profiles that were well matched with simulated results. This study suggests that the optimized films may present a better alternative to conventional tablets for the treatment of male erectile dysfunction.

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Formulation Optimization and <i>in Vitro</i> Characterization of Orally Disintegrating Films Using a Factorial Design and Mathematical Modeling for Drug Release

Lee

Thapa

Jeong

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…In general, (KUMAR et al, 2014), gelatina (BORGES et al, 2015), e álcool polivinílico (CHAVALA et al, 2015). Os polímeros utilizados na produção de filmes de desintegração oral podem ser utilizados isolados ou na forma de blendas; note-se que as concentrações utilizadas é um fator importante na produção dos filmes de desintegração oral (IRFAN et al, 2015).…”

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“…A utilização de compostos ativos naturais em filmes de desintegração oral é incipiente, entretanto podemos destacar a incorporação de extrato de própolis (JULIANO et al, 2007), extrato isolado da raíz de ginseng (WATANABE et al, 2009), extrato alcoólico de gengibre (DAUD, BONDE e SAPKAL, 2011) e extrato etanólico de própolis (BORGES et al, 2015). Desta forma a utilização de recursos naturais como fonte de compostos com atividades funcionais para adição de filmes de desintegração oral consiste em uma área importante a ser estudada.…”

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“…Diversos trabalhos disponíveis na literatura reportam a utilização da técnica de casting para a produção de filmes de desintegração oral (REPKA et al, 2005;CILURZO et al, 2008;GHORWADE et al, 2011;SAPKAL et al, 2011;MANHAR et al, 2013;JANßEN et al, 2013;MUZIBI et al, 2013;SAYED et al, 2013;MARQUES et al, 2014;BORGES et al, 2015;CHAVALA et al, 2015;ZHANG et al, 2015) Cilurzo et al (2008) Polietilenoglicol, glicerol Brniak et al (2015) Álcool polivinílico Chevala et al (2015) Glicerol Haque e Sheela (2015)…”

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“…Na literatura existem trabalhos que reportam a produção de filmes de desintegração à base de amido de milho (Liew et al, 2012), amido de ervilha (Preis et al, 2012), gelatina (Borges et al, 2015), gelatina e quitosana (Abruzzo et al, 2012), porém os autores não …”

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Desenvolvimento de matrizes poliméricas como veículo de ácido ascórbico: caracterização e avaliação da estabilidade

Garcia¹

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Gelatin and pregelatinized starch orally disintegrating films: Properties and stability of vitamin C

Garcia

Borges

Mazalli

et al. 2017

J of Applied Polymer Sci

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The administration of active compounds by the oral mucosa is an efficient method for the delivery of drugs and nutrients. This work aimed to develop and characterize orally disintegrating films (ODFs) based on starch and gelatin as carriers of vitamin C. The ODFs were produced using a casting technique by varying the concentrations of starch and gelatin (0, 20, 40, 60, 80, and 100 g of starch/100 g of polymer) and were characterized in relation to contact angle, opacity, surface pH, infrared spectroscopy, mechanical properties, morphology, and disintegration time (in vitro and in vivo). Additionally, the stability of vitamin C in the ODFs was evaluated by the incorporation of the dry extract of acerola (4 g/100 g of filmogenic solution). Generally, the ODFs presented hydrophilic characteristics with a neutral surface pH near the mouth, and films with higher starch concentrations showed greater rigidity. In vitro and in vivo tests indicated that ODFs may be classified as rapidly disintegrating. The ODFs produced with higher concentrations of starch showed a higher stability of the active compound, in addition to a shorter disintegration time. Starch‐ and gelatin‐based ODFs can be considered a new system for administering active ingredients via the oral mucosa. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44841.

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Orally Disintegrating Films Containing Propolis: Properties and Release Profile

Cited by 39 publications

References 61 publications

Formulation Optimization and <i>in Vitro</i> Characterization of Orally Disintegrating Films Using a Factorial Design and Mathematical Modeling for Drug Release

Formulation Optimization and <i>in Vitro</i> Characterization of Orally Disintegrating Films Using a Factorial Design and Mathematical Modeling for Drug Release

Desenvolvimento de matrizes poliméricas como veículo de ácido ascórbico: caracterização e avaliação da estabilidade

Gelatin and pregelatinized starch orally disintegrating films: Properties and stability of vitamin C

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