Orally administrated pterostilbene attenuates acute cerebral ischemia–reperfusion injury in a dose- and time-dependent manner in mice

Zhou, Yu; Zhang, Xuemei; Ma, Ang; Zhang, Yali; Chen, Yan-yi; Zhou, Hai-Rong; Li, Wenjun; Jin, Xin

doi:10.1016/j.pbb.2015.06.009

Cited by 30 publications

(22 citation statements)

References 48 publications

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“…S7E and S7F). Furthermore, several previous studies have shown that PTER is able to effectively cross the BBB , and minimum local and systemic toxicity of PTER in various animal models was reported (22,23). Therefore, to assess the efficacy of PTER in suppressing brain metastases in vivo , nude mice were inoculated with luciferase-labeled 231BrM cells by intracardiac injection followed by treatment with PTER (30mg/kg/day) or vehicle alone.…”

Section: Resultsmentioning

confidence: 96%

Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer

et al. 2016

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Brain metastasis is one of the chief causes of mortality in breast cancer patients, but the mechanisms that drive this process remains poorly understood. Here we report that brain metastatic cells expressing high levels of c-Met promote the metastatic process via inflammatory cytokine upregulation and vascular reprogramming. Activated c-Met signaling promoted adhesion of tumor cells to brain endothelial cells and enhanced neovascularization by inducing the secretion of IL-8 and CXCL1. Additionally, stimulation of IL1β secretion by activation of c-Met induced tumor-associated astrocytes to secrete the c-Met ligand HGF. Thus, a feed-forward mechanism of cytokine release initiated and sustained by c-Met fed a vicious cycle which generated a favorable microenvironment for metastatic cells. Reinforcing our results, we found that pterostilbene, a compound that penetrates the blood-brain barrier, could suppress brain metastasis by targeting c-Met signaling. These findings suggest a potential utility of this natural compound for chemoprevention.

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Section: Resultsmentioning

confidence: 96%

Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer

et al. 2016

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“…Furthermore, PT administration (10 minutes before reperfusion) markedly reduced myocardial caspase-3 activity, via lowering nitrative/ oxidative stress by attenuating peroxynitrite production, ROS generation and inflammatory response following myocardial IR injury [53]. Previous studies also lend the support for an anti-apoptotic role of PT in non-cardiac tissues such as brain [54] and skeletal muscle [55] following IR injury. Further, we extended our interest to explore whether PT has retained its anti-apoptotic effect against in vitro HR injury (an in vitro model of IR injury) in diabetic (high glucose, HG) condition using primary rat cardiomyocytes.…”

Section: Discussionmentioning

confidence: 99%

AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis

Kosuru

Cai

Kandula³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Pterostilbene (PT) exerts antidiabetic effects by decreasing blood glucose and modulating lipid metabolism and has been shown to attenuate myocardial ischemia-reperfusion (IR) injury in non-diabetic subjects. However, whether PT can protect against myocardial IR injury in diabetes is unknown. AMPK stimulation is indispensable in offering cardioprotection against myocardial IR injury in diabetes by limiting cardiac apoptosis. Thus, we hypothesized that PT may confer protection against myocardial IR injury in diabetes via AMPK activation. Methods: Sprague-Dawley rats at eight weeks of diabetes induction (induced by an intravenous dose of 65 mg/kg streptozotocin) were administered with vehicle or PT (20 and 40 mg/kg/day, p.o.) for four weeks (starting from week 9 to 12). At the end of week 12, myocardial IR injury was induced by subjecting the diabetic rats to 30 minutes of coronary artery ligation and followed by 2 hours of reperfusion. In in vitro studies, rat primary cardiomyocytes were incubated with low glucose (LG, 5.5 mM) or high glucose (HG, 30 mM) and exposed to 45 minutes hypoxia and 2 hours reoxygenation in the presence or absence of PT (0.5 µM) or the AMPK inhibitor compound C (CC, 5 µM). Results: PT significantly reduced post-ischemic cardiac infarct size, oxidative stress, plasma lactate dehydrogenase (LDH), creatine kinase-MB levels and apoptosis in diabetic rats. In cardiomyocytes, PT decreased hypoxia/ reoxygenation-induced oxidative stress, attenuated LDH and cleaved caspase3/caspase3 ratio and increased Bcl-2/Bax ratio and AMPK phosphorylation. However, CC administration blunted the cardioprotective effects of PT both in vivo and in vitro. Conclusion: Suppressing cardiac oxidative stress and apoptosis via AMPK stimulation may represent a primary mechanism whereby pterostilbene attenuates diabetic myocardial IR injury.

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“…In this current study, the combined treatment strategy of Pte administration in the presence of a 50 Hz, 1 mT ELF-MF was observed to be more efficient in treating ischemia-induced structural and functional alterations in kidneys in comparison to treatment with ELF-MF alone. In the literature, Pte has been shown to possess antioxidant and antiinflammatory actions and was found to be beneficial in treatment of ischemic damage in various tissues (Zhou et al, 2015;Cheng et al, 2016;Yu et al, 2017;Gao et al, 2018). Considering that the application of a magnetic field increases vascular permeability (Callaghan et al, 2008;Delle Monache et al, 2013;Pan et al, 2013) and antioxidant enzyme activities (Martínez-Sámano et al, 2010;Glinka et al, 2013), the applied magnetic field in the combined treatment group may have contributed to the observed beneficial effects by increasing the efficacy of endogenous antioxidants and by facilitating the delivery of Pte to damaged cells in the affected kidneys.…”

Section: Functional Groupsmentioning

confidence: 99%

Pterostilbene administration improves the recovery potential of extremely low-frequency magnetic field in acute renal ischemia-reperfusion injury: An FTIR spectroscopic study

et al. 2019

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Renal ischemia-reperfusion (I/R) injury, one of the drastic outcomes of renal failure and organ transplantation, tends to deteriorate over time; therefore, noninvasive therapeutic strategies will avail the progression-free survival of the patients. Magnetic field has been proposed as a noninvasive treatment strategy; however, with recent scientific advances, many controversies have arisen regarding its efficacy. Pterostilbene, a natural analog of resveratrol, was documented to be effective in treatment of I/R injuries. This study aims to assess the acute therapeutic effects of combined extremely low-frequency magnetic field (ELF-MF) and pterostilbene treatment on renal I/R injury. After induction of renal I/R in Wistar rats, treatments of 50 Hz, 1 mT ELF-MF applied alone or in combination with pterostilbene were applied for 5 consecutive days. Kidney homogenates were analyzed by Fourier transform infrared spectroscopy. I/R injury resulted in an altered protein and lipid structure with the dominance of longer acyl chains; a slight decrease in lipid, protein, unsaturated lipid, and unsaturated/saturated lipid content; and an increase in membrane fluidity and lipid peroxidation in rat kidneys. Although ELF-MF treatment alone was not sufficient to restore all ischemia-induced alterations, the combined treatment strategy of pterostilbene administration in the presence of ELF-MF was successful and warrants further investigation.

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Orally administrated pterostilbene attenuates acute cerebral ischemia–reperfusion injury in a dose- and time-dependent manner in mice

Cited by 30 publications

References 48 publications

Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer

Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer

AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis

Pterostilbene administration improves the recovery potential of extremely low-frequency magnetic field in acute renal ischemia-reperfusion injury: An FTIR spectroscopic study

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