Orally administered zingerone does not mitigate alcohol-induced hepatic oxidative stress in growing Sprague Dawley rat pups

Asiedu, Bernice; Lembede, Busisani W.; Nyakudya, Trevor Tapiwa; Chivandi, Eliton

doi:10.1080/01480545.2022.2085740

Cited by 2 publications

(2 citation statements)

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“…Presently, it is difficult to provide an explanation to these phenomena. In our recent study we observed that oral administration of ethanol during the suckling reduced the plasma triglyceride concentration of female rat pups [ 38 ]. We therefore speculate that the observed microsteatosis is likely due to the neonatal alcohol-induced export of triglycerides from the plasma to the liver.…”

Section: Discussionmentioning

confidence: 99%

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Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

et al. 2023

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Alcohol intake at different developmental stages can lead to the development of alcohol-induced fatty liver disease (AFLD). Zingerone (ZO) possess hepato-protective properties; thus, when administered neonatally, it could render protection against AFLD. This study aimed to evaluate the potential long-term protective effect of ZO against the development of AFLD. One hundred and twenty-three 10-day-old Sprague–Dawley rat pups (60 males; 63 females) were randomly assigned to four groups and orally administered the following treatment regimens daily during the pre-weaning period from postnatal day (PND) 12–21: group 1—nutritive milk (NM), group 2—NM +1 g/kg ethanol (Eth), group 3—NM + 40 mg/kg ZO, group 4—NM + Eth +ZO. From PND 46–100, each group from the neonatal stage was divided into two; subgroup I had tap water and subgroup II had ethanol solution as drinking fluid, respectively, for eight weeks. Mean daily ethanol intake, which ranged from 10 to 14.5 g/kg body mass/day, resulted in significant CYP2E1 elevation (p < 0.05). Both late single hit and double hit with alcohol increased liver fat content, caused hepatic macrosteatosis, dysregulated mRNA expression of SREBP1c and PPAR-α in male and female rats (p < 0.05). However, neonatal orally administered ZO protected against liver lipid accretion and SREBP1c upregulation in male rats only and attenuated the alcohol-induced hepatic PPAR-α downregulation and macrosteatosis in both sexes. This data suggests that neonatal orally administered zingerone can be a potential prophylactic agent against the development of AFLD.

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Section: Discussionmentioning

confidence: 99%

“…Interventions were administered from PND 12–21. Ethanol and zingerone dosage have previously been used in rat pups [ 35 , 37 , 38 ]. Nutritive milk was used as the vehicle for administration of the interventions.…”

Section: Methodsmentioning

confidence: 99%

Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

et al. 2023

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Changes in morphometric indicators of liver blood vessels under conditions of long-term ethanol exposure

Mykytenko,

Akimov,

Yeroshenko

et al. 2024

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Hyperdynamic splanchnic blood circulation is an important component of portal hypertension syndrome, which develops under conditions of chronic alcoholic hepatitis. Angiogenesis caused by alcohol consumption contributes to the development of splanchnic hyperemia and the development of portal-systemic collaterals. The purpose of the study is to study the morphometric indicators of the vascular bed of the liver of rats under the conditions of chronic alcoholic hepatitis modeling. Experiments were performed on 30 white, sexually mature male Wistar rats weighing 180–220 g. The animals were divided into 2 groups: I (control group) contained 6 rats; II – 24 rats that modeled chronic alcoholic hepatitis by the method of forced intermittent alcoholization for 5 days, with a repeat after two days by intraperitoneal injection of a 16.5% ethanol solution in a 5.0% glucose solution, at the rate of 4 ml/kg of body weight. Animals were removed from the experiment on days 35, 42, 49, and 56 by taking blood from the right ventricle of the heart under thiopental anesthesia. On the 35th day of simulation of chronic alcoholic hepatitis, the inner diameter of central veins, lobular arterioles and interlobular veins increased, and interlobular arteries and lobular venules decreased compared to the control. On the 42nd day of simulation of chronic alcoholic hepatitis, the internal diameter of central veins, lobular arterioles and interlobular veins increased, and interlobular arteries decreased compared to the control. On the 49th day of simulation of chronic alcoholic hepatitis, the inner diameter of the central veins, lobular arterioles, and interlobular veins increased, and the interlobular arteries decreased compared to the control. On the 56th day of simulation of chronic alcoholic hepatitis, the inner diameter of the central veins and lobular arterioles increased, and the interlobular arteries and lobular venules decreased compared to the control. Keywords: arteries, veins, arterioles, venules, sinusoidal capillaries.

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Orally administered zingerone does not mitigate alcohol-induced hepatic oxidative stress in growing Sprague Dawley rat pups

Cited by 2 publications

References 58 publications

Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

Changes in morphometric indicators of liver blood vessels under conditions of long-term ethanol exposure

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