Orally administered rubiscolin‐6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin‐type prostaglandin <scp>D</scp> synthase in mice

Kikuchi, Kentaro; Lazarus, Michael; Miyamoto, Chihiro; Oishi, Yo; Nagata, Nanae; Yang, Shao Nian; Yoshikawa, Masaaki; Aritake, Kosuke; Furuyashiki, Tomoyuki; Narumiya, Shuh; Urade, Yoshihiro; Ohinata, Kousaku

doi:10.1002/mnfr.201200155

Cited by 37 publications

(46 citation statements)

References 54 publications

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“…The food intake experiment was performed as described previously [12][13][14][15][16][17]. Briefly, individually housed male ddY mice were deprived of food pellets for 18 h with free access to water after acclimation for more than 3 days.…”

Section: Food Intakementioning

confidence: 99%

Characterization of Ile‐His‐Arg‐Phe, a novel rice‐derived vasorelaxing peptide with hypotensive and anorexigenic activities

Kontani

Omae

Kagebayashi

et al. 2013

Molecular Nutrition Food Res

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Section: Food Intakementioning

confidence: 99%

Characterization of Ile‐His‐Arg‐Phe, a novel rice‐derived vasorelaxing peptide with hypotensive and anorexigenic activities

Kontani

Omae

Kagebayashi

et al. 2013

Molecular Nutrition Food Res

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“…2000). The COX‐2 L‐PGDS system might mediate the orexigenic activity induced by δ opioid agonists (Kaneko et al in press). Further investigations will elucidate whether ovolin‐induced anxiolytic activity is mediated by COX‐2 activation.…”

Section: Discussionmentioning

confidence: 99%

Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic‐like activity

Oda

Kikuchi

Maekawa

et al. 2012

Journal of Neurochemistry

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J. Neurochem. (2012) 122, 356–362. Abstract We found that tryptic digest of ovalbumin after oral (p.o.) and intraperitoneal (i.p.) administration exhibited anxiolytic‐like activity in mice, and then searched for orally active low‐molecular‐weight peptides with anxiolytic‐like activity in the tryptic digest. Val‐Tyr‐Leu‐Pro‐Arg, named ovolin, corresponding to ovalbumin (280‐284), mimicked the anxiolytic‐like activity after p.o. and i.p. administration. The anxiolytic‐like activity of ovolin was inhibited by indomethacin, a cyclooxygenase (COX) inhibitor, or BWA868C, an antagonist of the DP1 receptor for prostaglandin (PG) D2. Ovolin‐induced anxiolytic‐like activity was also blocked by SCH58261 or bicuculline, antagonists of the adenosine A2A and GABAA receptors, respectively. Ovolin has no affinity for the DP1, A2A and GABAA receptors. Taken together, ovolin may exhibit anxiolytic‐like activity in a manner dependent on the PGD2‐DP1 system coupled to the A2A and GABAA receptors.

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“…Effect on food intake: Rubiscolin showed orexigenic effect for normal diet which was mediated successively by the PGD2-DP1 receptor and the neuropeptide Y-Y1 receptor systems downstream of the receptor [111]. We found previously that prostaglandin D2 has an orexigenic effect via DP1-R followed by the NPY-Y1-R receptor system [112,113].…”

Section: D) Rapeseed Proteinsmentioning

confidence: 94%

“…The peptide corresponds to hemoglobin -chain (105)(106)(107)(108)(109)(110)(111)(112)(113)(114)(115)(116) and was named hemotensin. Many kinds of antimicrobial peptides were reported to be released from hemoglobin [50].…”

Section: B) Blood Proteinsmentioning

confidence: 99%

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Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

Yoshikawa

2015

Peptides

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We have found various bioactive peptides derived from animal and plant proteins, which interact with receptors for endogenous bioactive peptides such as opioids, neurotensin, complements C3a and C5a, oxytocin, and formyl peptides etc. Among them, rubiscolin, a δ opioid peptide derived from plant RuBisCO, showed memory-consolidating, anxiolytic-like, and food intake-modulating effects. Soymorphin, a μ opioid peptide derived from β-conglycinin showed anxiolytic-like, anorexigenic, hypoglycemic, and hypotriglyceridemic effects. β-Lactotensin derived from β-lactoglobulin, the first natural ligand for the NTS2 receptor, showed memory-consolidating, anxiolytic-like, and hypocholesterolemic effects. Weak agonist peptides for the complements C3a and C5a receptors were released from many proteins and exerted various central effects. Peptides showing anxiolytic-like antihypertensive and anti-alopecia effects via different types of receptors such as OT, FPR and AT2 were also obtained. Based on these study, new functions and post-receptor mechanisms of receptor commom to endogenous and exogenous bioactive peptides have been clarified.

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Orally administered rubiscolin‐6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin‐type prostaglandin D synthase in mice

Abstract: Orally administered rubiscolin-6 may stimulate food intake through COX-2 and leptomeningeal L-PGDS, followed by DP(1) and Y(1) receptors, downstream of the central δ opioid receptor.

Cited by 37 publications

References 54 publications

Characterization of Ile‐His‐Arg‐Phe, a novel rice‐derived vasorelaxing peptide with hypotensive and anorexigenic activities

Characterization of Ile‐His‐Arg‐Phe, a novel rice‐derived vasorelaxing peptide with hypotensive and anorexigenic activities

Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic‐like activity

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

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