Orally administered recombinant baculovirus vaccine elicits partial protection against avian influenza virus infection in mice

Basak, Swarnendu; Chu, Ki‐Back; Kang, Hae‐Ji; Kim, Min-Ju; Lee, Su‐Hwa; Yoon, Keon-Woong; Jin, Hui; Suh, Joo Won; Moon, Eun‐Kyung; Quan, Fu‐Shi

doi:10.1016/j.micpath.2020.104495

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…Living delivery systems Recombinant bacteria [34][35][36][37][38][39][40][41][42][43][44] Viral vectors [45][46][47][48][49][50][51][52][53][54][55][56] Non-living delivery systems Virus-like particles [57] Micro-and nanoparticles [58][59][60] Lipid-based delivery systems [61][62][63][64][65][66][67][68][69] Nanogels [70] Targeted delivery M-cells Dectin-1 [71], GP2 [72], C5aR [73] Enterocytes FcRn [74] Aminopeptidase N [60,[75][76][77][78][79]…”

Section: Delivery Systemsmentioning

confidence: 99%

“…By genetically modifying them to express foreign antigens, viral vectors can be used as vaccine delivery vehicles to promote antigen-specific immune responses. Examples include the pox and measles viruses, alphaviruses, baculoviruses, adenoviruses or adeno-associated viruses [45,46,154,155]. They generally promote immune responses via stimulation of PRRs, such as TLR3, 7 and 8 or the RLRs, RIG-I and MDA-5 [156].…”

Section: Viral Vectorsmentioning

confidence: 99%

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Advances in Oral Subunit Vaccine Design

2020

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Many pathogens invade the host at the intestinal surface. To protect against these enteropathogens, the induction of intestinal secretory IgA (SIgA) responses is paramount. While systemic vaccination provides strong systemic immune responses, oral vaccination is the most efficient way to trigger protective SIgA responses. However, the development of oral vaccines, especially oral subunit vaccines, is challenging due to mechanisms inherent to the gut. Oral vaccines need to survive the harsh environment in the gastrointestinal tract, characterized by low pH and intestinal proteases and need to reach the gut-associated lymphoid tissues, which are protected by chemical and physical barriers that prevent efficient uptake. Furthermore, they need to surmount default tolerogenic responses present in the gut, resulting in suppression of immunity or tolerance. Several strategies have been developed to tackle these hurdles, such as delivery systems that protect vaccine antigens from degradation, strong mucosal adjuvants that induce robust immune responses and targeting approaches that aim to selectively deliver vaccine antigens towards specific immune cell populations. In this review, we discuss recent advances in oral vaccine design to enable the induction of robust gut immunity and highlight that the development of next generation oral subunit vaccines will require approaches that combines these solutions.

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Section: Delivery Systemsmentioning

confidence: 99%

Section: Viral Vectorsmentioning

confidence: 99%

Advances in Oral Subunit Vaccine Design

2020

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Baculovirus Display of Peptides and Proteins for Medical Applications

Rodríguez-Hernández

Martínez-Flores

Cruz-Reséndiz

et al. 2023

Viruses

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Baculoviridae is a large family of arthropod-infective viruses. Recombinant baculoviruses have many applications, the best known is as a system for large scale protein production in combination with insect cell cultures. More recently recombinant baculoviruses have been utilized for the display of proteins of interest with applications in medicine. In the present review we analyze the different strategies for the display of proteins and peptides on the surface of recombinant baculoviruses and provide some examples of the different proteins displayed. We analyze briefly the commercially available systems for recombinant baculovirus production and display and discuss the future of this emerging and powerful technology.

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Orally administered recombinant baculovirus vaccine elicits partial protection against avian influenza virus infection in mice

Cited by 2 publications

References 40 publications

Advances in Oral Subunit Vaccine Design

Advances in Oral Subunit Vaccine Design

Baculovirus Display of Peptides and Proteins for Medical Applications

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