Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice

Huang, Hui; Chieh, Shih Yung; Tso, Tim K.; Chien, Ting Yi; Lin, Hsin Tang; Tsai, Yao‐Chou

doi:10.1016/j.jep.2010.10.015

Cited by 45 publications

(18 citation statements)

References 26 publications

(24 reference statements)

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“…These findings indicate the potential for the use of the mushroom extract in stimulated angiogenesis, such as inflammation and tumor development (Lee et al 2010). Huang et al (2011) evaluated the anti-cancer effect of a mycelial culture of P . linteus and elucidated its potential mechanism in vivo.…”

Section: Anti-cancer Uses Of Mushroomsmentioning

confidence: 99%

Recent developments in mushrooms as anti-cancer therapeutics: a review

2011

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From time immemorial, mushrooms have been valued by humankind as a culinary wonder and folk medicine in Oriental practice. The last decade has witnessed the overwhelming interest of western research fraternity in pharmaceutical potential of mushrooms. The chief medicinal uses of mushrooms discovered so far are as anti-oxidant, anti-diabetic, hypocholesterolemic, anti-tumor, anti-cancer, immunomodulatory, anti-allergic, nephroprotective, and anti-microbial agents. The mushrooms credited with success against cancer belong to the genus Phellinus, Pleurotus, Agaricus, Ganoderma, Clitocybe, Antrodia, Trametes, Cordyceps, Xerocomus, Calvatia, Schizophyllum, Flammulina, Suillus, Inonotus, Inocybe, Funlia, Lactarius, Albatrellus, Russula, and Fomes. The anti-cancer compounds play crucial role as reactive oxygen species inducer, mitotic kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoisomerase inhibitor, leading to apoptosis, and eventually checking cancer proliferation. The present review updates the recent findings on the pharmacologically active compounds, their anti-tumor potential, and underlying mechanism of biological action in order to raise awareness for further investigations to develop cancer therapeutics from mushrooms. The mounting evidences from various research groups across the globe, regarding anti-tumor application of mushroom extracts unarguably make it a fast-track research area worth mass attention.

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Section: Anti-cancer Uses Of Mushroomsmentioning

confidence: 99%

Recent developments in mushrooms as anti-cancer therapeutics: a review

2011

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“…In basidiomycetes, particularly those from the polyporus genera of Inonotus and Phellinus, predominant metabolites from the phenylpropanoid pathway include the styrylpyrone polyphenols that possess anti-oxidative, anti-inflammatory, anti-diabetic, antitumor and antiviral activities (Huang et al 2011;Lee and Yun 2011). These polyporus basidiomycetes are thus thought to be a unique source for producing structurally diversified and biologically active natural products (Huang et al 2007;Guo et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Correlation of nitric oxide produced by an inducible nitric oxide synthase-like protein with enhanced expression of the phenylpropanoid pathway in Inonotus obliquus cocultured with Phellinus morii

Zhao

et al. 2015

Appl Microbiol Biotechnol

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Fungal interspecific interactions enhance biosynthesis of phenylpropanoid metabolites (PM), and production of nitric oxide (NO) is known to be involved in this process. However, it remains unknown which signaling pathway(s) or regulator(s) mediate fungal PM biosynthesis. In this study, we cocultured two white-rot fungi, Inonotus obliquus and Phellinus morii, to examine NO production, expression of the genes involved in phenylpropanoid metabolism and accumulation of phenylpropanoid-derived polyphenols by I. obliquus. Coculture of the two fungi caused an enhanced NO biosynthesis followed by increased transcription of the genes encoding phenylalanine ammonia lyase (PAL) and 4-coumarate CoA ligase (4CL), as well as an upregulated biosynthesis of styrylpyrone polyphenols in I. obliquus. Addition of the NO synthase (NOS) selective inhibitor aminoguanidine (AG) inhibited NO production by more than 90% followed by cease in transcription of PAL and 4Cl. Treatment of guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one did not affect NO production but suppressed transcription of PAL and 4CL and reduced accumulation of total phenolic constituents. Genome-wide analysis of I. obliquus revealed two genes encoding a constitutive and an inducible NOS-like protein, respectively (cNOSL and iNOSL). Coculture of the two fungi did not increase the expression of the cNOSL gene but triggered expression of the iNOSL gene. Cloned iNOSL from Escherichia coli shows higher activity in transferring L-arginine to NO, and this activity is lost upon AG addition. Thus, iNOSL is more responsible for NO production in I. obliquus and may act as an important regulator governing PM production during fungal interspecific interactions.

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“…The patient ingested this mushroom daily and a significant regression of hepatic lesion was observed by same CT scan, 9 month after treatment (131) . Some in vivo and in vitro studies have also demonstrated that P. linteus exerts antitumor effects on HCC (132)(133)(134) . The hepatoprotective potential of P. linteus polysaccharide extract has been described by Wang A c c e p t e d M a n u s c r i p t 22 mediated hepatotoxicity by restoring the liver antioxidant status, inhibiting phase I and enhancing phase II enzyme activities (139) .…”

Section: Phellinus Linteus (Family: Hymenochaetaceae): Phellinus Lintmentioning

confidence: 99%

Include mushroom in daily diet—A strategy for better hepatic health

Chatterjee

Acharya

2015

Food Reviews International

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Liver, the most important metabolic organ of the body is also the major organ for the detoxification of the blood stream. If the accumulation of toxins is faster than their removal by liver, hepatic damage occurs. Although synthetic drugs are available in the market, long term use of such drugs has consequential side effects. Therefore, the growing need to find safe, costeffective drugs devoid of adverse effects is spawning extensive research. Mushrooms are rising as a major medicinal food and pharmaceuticals. This review summarizes the medicinal value of different edible mushrooms on free radical, xenobiotic and drug induced hepatotoxicity.

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Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice

Cited by 45 publications

References 26 publications

Recent developments in mushrooms as anti-cancer therapeutics: a review

Recent developments in mushrooms as anti-cancer therapeutics: a review

Correlation of nitric oxide produced by an inducible nitric oxide synthase-like protein with enhanced expression of the phenylpropanoid pathway in Inonotus obliquus cocultured with Phellinus morii

Include mushroom in daily diet—A strategy for better hepatic health

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