Orally Administered Combination of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin in the Prevention of Postcoital Recurrent Urinary Tract Infections: Analysis of 98 Women in Reproductive Age After 6 Months of Treatment

Schiavi, Michele Carlo; Porpora, Maria Grazia; Vena, Flaminia; Prata, Giovanni; Sciuga, Valentina; D’Oria, Ottavia; Tucci, Chiara Di; Savone, Delia; Aleksa, Natalia; Giannini, Andrea; Nusiner, Maria Paola; Zullo, Marzio Angelo; Muzii, Ludovico; Panici, Pierluigi Benedetti

doi:10.1097/spv.0000000000000560

Cited by 18 publications

(13 citation statements)

References 32 publications

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“…All these benefits (MBS, FSFI, FSDS, VHI) were attributable CO 2 laser treatment since the patients' population was accurately selected by excluding confounding factors such as lubricants-use or ongoing hormonal therapies. Our findings stand in line with recent literature [2,5,[7][8][9][10][11][12][13]32].…”

Section: Discussionsupporting

confidence: 93%

“…The syndrome includes vulvovaginal atrophy (VVA), as well as urinary and sexual disorders, compromising quality of life (QoL) in as many as 50% of postmenopausal women [2,3]. Several therapeutic options have been proposed for the relief of GSM symptoms, including both hormonal and nonhormonal products [4][5][6][7][8]. The main therapeutic goal remains the relief of associated symptoms and signs, which could be ideally achieved through the restoration of the urogenital physiology.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, the CO 2 laser fractionally ablates the tissue, causing immediate heat-induced collagen contraction and subsequent tissue remodeling, improving elasticity of vaginal canal by increasing the extracellular matrix of the mucosa and increasing the muscle tone. Different studies have successfully evaluated the effectiveness of CO 2 laser for the treatment of VVA symptoms, however now, to our knowledge, there is no prospective study performed who could confirm its effectiveness on a large number of patients [4][5][6][7][8][9][10][11][12][13]. Recent studies have a longer follow-up, but on an extremely limited number of patients [14].…”

Section: Introductionmentioning

confidence: 99%

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The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study

Donato¹,

D’Oria²,

Giannini³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: Genitourinary syndrome of menopause (GSM) majorly caused by the physiological decline in estrogen, affects up to 90% of menopausal women. Hormonal therapy seems to be an effective treatment, often not executable for contraindication or patient's low compliance to local or systemic medical therapy. Fractional CO 2 laser therapy is an emerging and effective choice for women affected by vulvo-vaginal atrophy (VVA), promoting collagen regeneration and improving blood flow of the vaginal mucosa and elasticity of tissues. Methods: Ninety-two menopausal Patients affected by vulvo-vaginal atrophy (VVA) were considered for the present prospective observational study. All women were treated with Fractional CO 2 laser Lumenis AcuPulse in a fractionated sequential mode laser pulse. Patients were requested to complete questionnaires regarding the Female Sexual Functional Index (FSFI), Female Sexual Distress Scale (FSDS) and severity of Most Bothersome Symptoms (MBS) at baseline (T0) and at three-month following three-treatment-sessions (T1). Results: Data indicated a significant improvement of MBS (vaginal itching (p < 0.0001), post-coital vaginal bleeding (p < 0.002), vaginal dryness (p < 0.0001), dyspareunia (p < 0.0001) and dysuria (p < 0.0001), higher Vaginal Health Index Score (VHIS) (4.1 ± 1.21; 95% CI = 3.84-4.35) and reduces pH (-0.53 ± 0.24; 95% CI = 0.48-0.58) after CO 2 laser treatment. A significantly improvement of FSFI Total score (p < 0.0001) and FSDS (p < 0.0001) have been demonstrated. Conclusions: Fractional CO 2 laser improves vaginal health as well as signs and symptoms associated with GSM, while significantly elevating quality of life and sexual functionality among postmenopausal symptomatic women.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study

Donato¹,

D’Oria²,

Giannini³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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“…In a clinical trial conducted by Schiavi et al (Schiavi et al, ) to determine the combined effect of hyaluronic acid, chondroitin sulfate, turmeric and acorn on the prevention of recurrent UTI following coidus, 98 women of reproductive age were selected and assessed in terms of pelvic pain, urinary frequency, and urinary urgency using the UTI Symptom Assessment questionnaire. The results showed significant reductions in UTI symptoms including urgency, frequency, dysuria, suprapubic pain, hematuria, and nocturia in the intervention group.…”

Section: Discussionmentioning

confidence: 99%

The effect of Seidlitzia rosmarinus (eshnan) on the prevention of recurrent cystitis in women of reproductive age: A randomized, controlled, clinical trial

Kamalifard

Abbasalizadeh

Mirghafourvand

et al. 2019

Phytotherapy Research

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The World Health Organization has recommended herbal medicine for treatment and control of recurrent cystitis. This study was conducted to determine effect of eshnan on the prevention of recurrent cystitis. The present triple-blind clinical trial was conducted on 126 women (63 women per group) with recurrent cystitis. The participants were assigned to the intervention and control groups. Three 500-mg eshnan or placebo tablets were taken orally with a glass full of water by the participants half an hour after each meal for 2 months. The study subjects were clinically and paraclinically evaluated by the end of the second, fourth, and sixth months after the intervention and every time they showed clinical symptoms of cystitis. The present findings showed that the incidence rate of cystitis and symptoms of cystitis was significantly lower in the eshnan group compared with the placebo group 2, 4, and 6 months after the intervention (p < .05). The incidence of recurrent was also significantly lower in the intervention group compared with the control group (p < .001).No side effects were observed in the intervention and control groups. The consumption of eshnan can improve the symptoms of cystitis and prevent the incidence of recurrent cystitis in women of reproductive age.

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“…Lower tract urinary dysfunctions are one of the most important and ongoing health problems worldwide, especially in women [5][6][7][8] and may cause a severe impairment of quality of life [9,10]. Different approaches and interventions have been developed in this peculiar field, all embracing new devices with a broad utility [11][12][13][14].…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Sacral neuromodulation for refractory lower urinary tract dysfunctions: a single-center retrospective cohort study

Culmone¹,

Speciale²,

Guastella³

et al. 2022

Ital J Gynaecol Obstet

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Introduction: Sacral neuromodulation (SNM) is a technique that electrically stimulates the third sacral spinal nerve root to modulate a neural pathway. In this study, we present our 7-years ' experience outcomes and complications of SNM in lower urinary tract dysfunctions. Methods:We performed a single-center retrospective cohort study of all patients who underwent InterStim Medtronic SNM device implantation for lower urinary tract dysfunction. All procedures were performed between January 2014 and November 2021 in the Urogynecologycal Center of Villa Sofia Hospital in Palermo by a single expert team. We included 68 patients with refractory lower urinary tract dysfunction who did not adequately respond to primary therapeutical strategies. Results:We observed a reduction rate of catheterization from a mean of 4.05 to 1.22. In addition, the amount of post-voidal residual decreased from a mean of 520 ml to 187 ml. Among the 41 women in the overactive bladder group, only 36 were included in the follow-up; 24 of the 36 patients (66.6%) had no episodes of leaks; the remaining patients (33.4%) had a significant reduction of leaks. We also recorded a significant reduction in urinary frequency: voids per day decreased from 16.1 at baseline to 6.1. Among the 7 women with BPS, only 5 patients (71.42%) completed the follow-up protocol. They reported satisfaction from the treatment: no patients chronically used pain drugs, and only 1 used occasionally painkillers. Conclusion:SNM treatment has been found as a potential effective and feasible option for urogynecologycal disorders.

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Orally Administered Combination of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin in the Prevention of Postcoital Recurrent Urinary Tract Infections: Analysis of 98 Women in Reproductive Age After 6 Months of Treatment

Abstract: Oral administration of a combination of HA, CS, curcumin, and quercetin is a valid and well-tolerated nonantibiotic treatment for prevention of postcoital UTI in reproductive age women.

Cited by 18 publications

References 32 publications

The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study

The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study

The effect of Seidlitzia rosmarinus (eshnan) on the prevention of recurrent cystitis in women of reproductive age: A randomized, controlled, clinical trial

Sacral neuromodulation for refractory lower urinary tract dysfunctions: a single-center retrospective cohort study

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