Oral yeast colonization in patients with primary and secondary Sjögren's syndrome

Medeiros, Clarissa Castro Galvão; Borges, Luiz Gustavo dos Anjos; Cherubini, Karen; Salum, Fernanda Gonçalves; Silva, Renata Medina da; Figueiredo, Maria Antonia Zancanaro de

doi:10.1111/odi.12896

Cited by 13 publications

(9 citation statements)

References 43 publications

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“…Effects of decreased salivary secretion on the oral microbiome have been discussed in the context of Sjögren's syndrome and side effects of radiotherapy and drug therapies [33][34][35]. Such studies have commonly reported higher detection rates of Lactobacilli and C. albicans; however, the present study showed a low detection rate of Lactobacilli and no signi cant difference between children with DS and ND group.…”

Section: Discussioncontrasting

confidence: 59%

Salivary Microbiome in Children With Down Syndrome

Morishima¹,

Takeda²,

Greenan³

et al. 2021

Preprint

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Down syndrome (DS), a most frequently occurring genetic disorder, is associated with oral morphological abnormalities and higher incidence rates of oral diseases. Recent studies have analyzed the oral microbiome to elucidate their relationships with oral diseases and general health; however, reports on the oral microbiome in individuals with DS are scarce. This study aimed to characterize the oral microbiome in children with DS. The salivary microbiomes of children with DS (DS) and children without DS (ND) aged 1 to 12 years were compared. Results of culture and quantitative polymerase chain reaction (qPCR) detection tests for cariogenic and periodontopathic bacteria showed no significant differences in the detected bacteria between the DS and ND groups, with the exception of a significantly higher detection rate of Candida albicans in children with DS with mixed dentition. A comparison of the salivary microbiomes by 16S sequencing showed no significant difference in α diversity; however, it showed a significant difference in β diversity. Children with DS had a higher relative abundance of Corynebacterium and Cardiobacterium, and lower relative abundance of TM7. This study provided basic data on the salivary microbiome of children with DS and further identified a characteristic microbiological marker of children with DS.

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Section: Discussioncontrasting

confidence: 59%

Salivary Microbiome in Children With Down Syndrome

Morishima¹,

Takeda²,

Greenan³

et al. 2021

Preprint

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“…In fact, some authors have studied both types of saliva in pSS patients and have reported high Candida counts associated to both lower rates of SWS and UWS, although without demonstrating statistical significance ( 22 , 23 ). Similarly, there are studies reporting that when C. albicans is higher UWS is decreased ( 2 , 24 , 25 ), some demonstrating a significant relationship ( 2 , 25 ). In other studies, however, the association was with SWS rather than UWS ( 26 ).…”

Section: Discussionmentioning

confidence: 92%

“…Primary Sjögren’s syndrome (pSS) is a systemic autoimmune exocrinopathy that damages the salivary and lacrimal glands, resulting in dry eyes and hyposalivation ( 1 , 2 ). Saliva contains IgA, lysozyme and lactoferrin, which are important antimicrobial defence mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Risk factors related to oral candidiasis in patients with primary Sjögren’s syndrome

Serrano

López‐Pintor²,

Ramı́rez³

et al. 2020

Med Oral

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Background Candidiasis is the most frequent mycotic infection of the oral cavity. The aim of this study was to investigate the presence of clinical oral candidiasis and Candida albicans yeast in a population diagnosed of primary Sjögren’s syndrome (pSS) and to study the possible factors associated with this infection. Material and Methods An observational cross-sectional study was conducted in 61 pSS patients (60 women, 1 man, mean age 57.64±13.52) where patient based information (demographic and medical, tobacco and alcohol consumption history), intraoral parameters (presence of dentures, clinical signs of candidiasis), salivary analytical information (number of Candida albicans as colony-forming units per millilitre (CFU/mL), salivary pH levels, unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. Results 13.1% of pSS patients presented oral signs of candidiasis. Denture stomatitis and angular cheilitis were the most common lesions. 87.5% of patients with clinical candidiasis presented reduced pH levels and salivary flow in both UWS and SWS. A significant statistical negative correlation was found between CFU/mL of Candida albicans and levels of UWS and SWS. A negative correlation was found between pH levels and CFU/mL, although not statistically significant. Conclusions A reduced salivary flow may predispose pSS patients to Candida albicans overgrowth, which may show with clinical signs. Preventive measures are of great importance to avoid and to treat this condition promptly. Key words: Sjögren’s syndrome, oral candidiasis, oral lesions, Candida albicans, oral yeast, salivary flow rate, hyposalivation.

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“…Sjögren syndrome (SS) is a systemic autoimmune exocrinopathy of unknown aetiology. Different predisposing factors along with several immune-related processes have been described in its pathogenesis, supporting the idea of a multifactorial disease (1). It can occur as primary SS (pSS), when it courses as an isolated disorder or as secondary SS when it appears in association with another systemic autoimmune disease (2).…”

Section: Introductionmentioning

confidence: 85%

“…It can occur as primary SS (pSS), when it courses as an isolated disorder or as secondary SS when it appears in association with another systemic autoimmune disease (2). pSS usually emerges in the 4 th -5 th decade of life, affecting women more than men, in a proportion 9:1, and its prevalence rates range between 0.1 to 4.8% (1,3,4). pSS is a chronic inflammatory disease characterized by lymphocytic infiltration of the lacrimal and salivary glands resulting in the primary symptoms of this condition: presence of dry eyes and hyposalivation.…”

Section: Introductionmentioning

confidence: 99%

Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study

Serrano

López‐Pintor²,

Fernández‐Castro³

et al. 2020

Med Oral

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Oral yeast colonization in patients with primary and secondary Sjögren's syndrome

Abstract: This study showed that C. albicans is the most prevalent yeast, but also that a variety of other yeast species can colonize the oral cavity of Sjogren's syndrome patients. The identification of most of the colonies was not obtained by culturing-PCR methods combined.

Cited by 13 publications

References 43 publications

Salivary Microbiome in Children With Down Syndrome

Salivary Microbiome in Children With Down Syndrome

Risk factors related to oral candidiasis in patients with primary Sjögren’s syndrome

Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study

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