Oral vitamin D3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis

Charoenngam, Nipith; Rujirachun, Pongprueth; Holick, Michael F.; Ungprasert, Patompong

doi:10.1007/s00198-019-05102-7

Cited by 33 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, this kind of classification results in two clearly distinct subgroups and is thus an established methodological approach in case that individual participant data are not available. Notably, our results are in line with another meta-analysis, which reported a significant increase in FGF-23 concentrations by vitamin D supplementation in individuals with initial 25-hydroxyvitamin D concentrations below 50 nmol/l [3].…”

Section: To the Editorsupporting

confidence: 92%

Reply to Meshkini et al.

2021

View full text Add to dashboard Cite

Section: To the Editorsupporting

confidence: 92%

Reply to Meshkini et al.

2021

View full text Add to dashboard Cite

“…Charoenngam et al [100] in their meta-analysis also demonstrated that serum intact FGF23 concentration increased strongly after oral 1,25(OH)2D3 supplementation in Vitamin D-deficient participants, with a pooled standardized mean difference of 0.36 (95%CI 0.14 to 0.57; p = 0.001).…”

Section: Fgf23-klotho and Vitamin D Axis In Endocrine-paracrine Renalmentioning

confidence: 91%

Protective Role of Vitamin D in Renal Tubulopathies

et al. 2020

View full text Add to dashboard Cite

Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3. Patients with renal impairment or tubular injury often suffer from chronic inflammation. This alteration comes from oxidative stress, acidosis, decreased clearance of inflammatory cytokines and stimulation of inflammatory factors. The challenge is to find the right formula for each patient to correctly modulate the landscape of treatment and preserve the essential functions of the organism without perturbating its homeostasis. The complexity of the counter-regulation mechanisms and the different axis involved in the Vitamin D equilibrium pose a major issue on Vitamin D as a potential effective anti-inflammatory drug. The therapeutic use of this compound should be able to inhibit the development of inflammation without interfering with normal homeostasis. Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.

show abstract

“…In addition, 1,25(OH) 2 D forms an endocrine system together with parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) to regulate calcium and phosphate homeostasis [ 8 ]. As a part of negative feedback loops, 1,25(OH) 2 D directly inhibits PTH production, leading to a decrease in bone resorption and increased urinary calcium excretion, and induces FGF23 production by the osteocytes, leading to an increase in urinary phosphate excretion [ 6 , 8 , 9 ].…”

Section: Physiology Of Vitamin Dmentioning

confidence: 99%

Immunologic Effects of Vitamin D on Human Health and Disease

2020

View full text Add to dashboard Cite

Vitamin D is responsible for regulation of calcium and phosphate metabolism and maintaining a healthy mineralized skeleton. It is also known as an immunomodulatory hormone. Experimental studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, exerts immunologic activities on multiple components of the innate and adaptive immune system as well as endothelial membrane stability. Association between low levels of serum 25-hydroxyvitamin D and increased risk of developing several immune-related diseases and disorders, including psoriasis, type 1 diabetes, multiple sclerosis, rheumatoid arthritis, tuberculosis, sepsis, respiratory infection, and COVID-19, has been observed. Accordingly, a number of clinical trials aiming to determine the efficacy of administration of vitamin D and its metabolites for treatment of these diseases have been conducted with variable outcomes. Interestingly, recent evidence suggests that some individuals might benefit from vitamin D more or less than others as high inter-individual difference in broad gene expression in human peripheral blood mononuclear cells in response to vitamin D supplementation has been observed. Although it is still debatable what level of serum 25-hydroxyvitamin D is optimal, it is advisable to increase vitamin D intake and have sensible sunlight exposure to maintain serum 25-hydroxyvitamin D at least 30 ng/mL (75 nmol/L), and preferably at 40–60 ng/mL (100–150 nmol/L) to achieve the optimal overall health benefits of vitamin D.

show abstract

Oral vitamin D3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis

Cited by 33 publications

References 28 publications

Reply to Meshkini et al.

Reply to Meshkini et al.

Protective Role of Vitamin D in Renal Tubulopathies

Immunologic Effects of Vitamin D on Human Health and Disease

Contact Info

Product

Resources

About