Oral Vitamin D Therapy in Patients with Psoriasis

Abstract

Vitamin D treatment is effective when applied topically to the skin for plaque-type psoriasis. Oral vitamin D supplementation might be effective as an adjuvant treatment option in psoriasis. This umbrella review aimed to highlight the current knowledge regarding the use of oral vitamin D for treatment of patients with psoriasis. We performed a literature search and identified 107 eligible full-text articles that were relevant to the research interest. Among these, 10 review articles were selected, and data were extracted. A data synthesis showed that only a few studies monitored oral vitamin D efficacy in patients with psoriasis. No studies investigated the optimal dose of systemic vitamin D in psoriasis. However, most studies did not observe side effects for doses within a relatively narrow range (0.25 to 2 μg/day). These results suggest that more large-scale studies are needed to determine the efficacy, optimal dose, and adverse effects of vitamin D administration in patients with psoriasis.

Allergic Contact Cell-Mediated Hypersensitivity in Psoriasis: A Narrative Minireview

“…Regarding pregnancy and lactation, skin patch testing may be performed if there are urgent reasons for the workup of contact allergies and postponement is not desirable [ 73 ], but psoriasis treatment decisions are difficult to make under these conditions [ 74 , 75 , 76 ]. To the best of our knowledge, there are no reports of positive patch tests in pregnant or lactating women treated with biologics for psoriasis.…”

The Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects

“…Consequently, vitamin D and its analogs are considered as important factors supporting eradication of psoriatic plaques [ 144 , 145 ]. Several studies have proved that vitamin D analogs could be successfully used as supplements to compensate for vitamin D deficiency [ 146 , 147 ]; they could also be used directly through topical application [ 148 , 149 ]. Recently, high doses of vitamin D were found to be efficient in eradication of psoriatic plaques [ 150 ].…”

Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis

“…Lesions are often located on exposed parts of the body, which results in significant psychological and social pressure on patients and seriously affects their physical and mental health and quality of life [ 1 , 2 , 3 ]. Patients with psoriasis are also at increased risk of metabolic syndrome [ 4 , 5 , 6 ]. However, the etiology and pathogenesis of psoriasis are not completely known.…”