Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis

Cabalín, Carolina; Pérez-Mateluna, Guillermo; Iturriaga, Carolina; Camargo, Carlos A.; Borzutzky, Arturo

doi:10.1007/s00403-022-02416-1

Cited by 8 publications

(10 citation statements)

References 53 publications

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“…21 Oral vitamin D3 supplementation in children with atopic eczema reduces AD severity through increasing the epidermal expression of the vitamin D receptor and cathelicidin in lesional skin. 22 NICE and RCPCH recommend treatment of vitamin D deficiency in children for 8-12 weeks (colecalciferol 3000IU daily aged 1-5 months, 6000IU daily aged 6months-11 years, 10,000IU daily aged 12-17 years), while they recommend supplementation of vitamin D (colecalciferol 400-600IU daily) for children with vitamin D insufficiency. 23 The presence of FLG LOFM has been linked to higher vitamin D levels, with the suggestion that the presence of these variants favours intracutaneous vitamin D3 production in people with Northern European ancestry.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and atopic dermatitis severity in a Bangladeshi population living in East London: A cross‐sectional study

McCarthy,

Tawfik,

Theocharopoulos

et al. 2024

Skin Health and Disease

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BackgroundAtopic eczema is a common, chronic, inflammatory skin condition with considerable heterogeneity. South Asian people living in the UK frequently have low serum vitamin D3 (25(OH)D3), and those with atopic disease can present with severe eczema. The association between vitamin D deficiency and eczema severity, and the role of vitamin D supplementation in atopic eczema is inconsistent, and under‐researched in people with Asian ancestry.ObjectivesThis cross‐sectional study investigates the association between serum 25(OH)D3 and eczema severity in a cohort of South Asian children and young adults living in London.MethodsEligible participants were Bangladeshi children and young adults aged 0–30 years with eczema, living in London and participating in the Tower Hamlets Eczema Assessment study. Data was collected via parent/patient self‐reporting, clinical history and examination, and hospital databases. 25(OH)D3 levels were documented retrospectively, if available, from hospital databases. Eczema severity was classified by Eczema Area and Severity Index (EASI) score less than or greater than 10 (clear‐mild vs. moderate‐severe). Multivariate logistic regression was used to adjust for confounding factors.Results681 participants were included in analyses. 25(OH)D3 results were available for 49.6% (338/681), 84.3% of which had deficient or insufficient lowest 25(OH)D3. Lowest 25(OH)D3 was inversely correlated with EASI score (Spearman's rank R2 = −0.24, p < 0.001). 26.1% (178/681) had EASI >10 and a lower median lowest and nearest 25(OH)D3. After adjustment for confounding EASI > 10 was significantly associated with a lowest 25(OH)D3 < 25 (OR 3.21, 95%CI 1.35, 8.60), use of mild‐moderate potency topical steroid on the face and neck (OR 3.11, 95%CI 1.86, 5.31), calcineurin inhibitor on the face and neck (OR 2.79, 95% CI 1.26, 6.10) and potent – very potent topical steroid on the face and neck (OR2.23, 95%CI 1.02, 4.77) and body (OR 2.11, 95%CI 1.18, 3.87).DiscussionVitamin D plays a role in modulation of proteins required for skin barrier function and regulation of the innate immune system, suggesting 25(OH)D3 deficiency contributes to skin inflammation. This study demonstrates a relationship between 25(OH)D3 deficiency and worse eczema severity in a cohort of South Asian children and young adults.

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and atopic dermatitis severity in a Bangladeshi population living in East London: A cross‐sectional study

McCarthy,

Tawfik,

Theocharopoulos

et al. 2024

Skin Health and Disease

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“…Three separate studies demonstrated that prebiotic supplementation has effective long-term protective effects on AD and were associated with a reduction in plasma levels of total IgE [112] and a lowered risk of AD [113]. For vitamin supplementation, vitamin D3 (n = 12) [70][71][72][73][74][75][76][77][78][79][80] was exclusively studied in the pediatric population, while investigations on dietary fats (n = 4) explored γ-linolenic acid [81,82], docosahexaenoic acid [83,84], and arachidonic acid [83]. Studies on diet-related approaches (n = 5) involved avoidance of monosodium glutamate [118], eggs [120,122] and/or cow's milk [120], supplementation with whey or casein [121], and selected foods consumption [119].…”

Section: Pediatric Populationmentioning

confidence: 99%

Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis

Lim,

Liu,

Chew

2024

Int Arch Allergy Immunol

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Background: This scoping review aims to critically assess gaps in the current literature on atopic dermatitis (AD) by evaluating the overall effectiveness of dietary interventions. Through a comprehensive analysis that follows the Preferred Reporting Item for Systematic Review and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines, we conducted a thorough search on the Web of Science database in May 2023 using specific search strategies to identify all relevant studies on the research topic. Summary: A total of 104 full-text articles were included for review. Our synthesis identified seven notable categories of dietary interventions for AD, showcasing the diversity of interventions utilized. This includes vitamin supplementation, probiotic and prebiotic supplementation, dietary fat, biological compounds, foods from natural sources, major nutrients, and diet-related approaches. Further analyses stratified by targeted populations revealed a predominant focus on pediatrics, particularly in probiotic supplementation, and on adults, with an emphasis on vitamin D and E supplementation. Key Messages: Despite most dietary interventions demonstrating overall effectiveness in improving AD severity and its subjective symptoms, several significant gaps were identified. There was a scarcity of studies on adults and whole-diet interventions, a prevalence of short-term interventions, heterogeneity in study outcomes, designs, and population, occasional disparity between statistical significance and clinical relevance, and a lack of a comprehensive multidisciplinary approach. Nonetheless, these findings offer valuable insights for future AD research, guiding additional evidence-driven dietary interventions and informing healthcare professionals, researchers, and individuals, advancing both understanding and management of AD.

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“…A randomised trial showed that patients with septic shock and severe sepsis rapidly induced LL-37 expression after vitamin D supplementation [126]. According to a report, vitamin D supplementation induced LL-37 in children with atopic dermatitis [157]. Furthermore, vitamin D supplementation enhanced the expression of LL-37 and increased the resistance to SARS-CoV-2 viral infection in COVID-19 patients [122].…”

Section: Sepsis and Infectious Diseasesmentioning

confidence: 99%

Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases

Santa

Watanabe

Kumazawa

et al. 2023

IJMS

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A variety of phytocompounds contained in medical plants have been used as medication, including Kampo (traditional Japanese) medicine. Phytochemicals are one category of the chemical compounds mainly known as antioxidants, and recently, their anti-inflammatory effects in preventing chronic inflammation have received much attention. Here, we present a narrative review of the health-promotion and disease-prevention effects of phytochemicals, including polyphenols, the latter of which are abundant in onions, oranges, tea, soybeans, turmeric, cacao, and grapes, along with the synergetic effects of vitamin D. A phenomenon currently gaining popularity in Japan is finding non-disease conditions, so-called ME-BYO (mibyou) and treating them before they develop into illnesses. In addition to lifestyle-related diseases such as metabolic syndrome and obesity, dementia and frailty, commonly found in the elderly, are included as underlying conditions. These conditions are typically induced by chronic inflammation and might result in multiple organ failure or cancer if left untreated. Maintaining gut microbiota is important for suppressing (recently increasing) intestinal disorders and for upregulating immunity. During the COVID-19 pandemic, the interest in phytochemicals and vitamin D for disease prevention increased, as viral and bacterial infection to the lung causes fatal inflammation, and chronic inflammation induces pulmonary fibrosis. Furthermore, sepsis is a disorder inducing severe organ failure by the infection of microbes, with a high mortality ratio in non-coronary ICUs. However, antimicrobial peptides (AMPs) working using natural immunity suppress sepsis at the early stage. The intake of phytochemicals and vitamin D enhances anti-inflammatory effects, upregulates immunity, and reduces the risk of chronic disorders by means of keeping healthy gut microbiota. Evidence acquired during the COVID-19 pandemic revealed that daily improvement and prevention of underlying conditions, in terms of lifestyle-related diseases, is very important because they increase the risk of infectious diseases. This narrative review discusses the importance of the intake of phytochemicals and vitamin D for a healthy lifestyle and the prevention of ME-BYO, non-disease conditions.

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Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis

Cited by 8 publications

References 53 publications

Vitamin D deficiency and atopic dermatitis severity in a Bangladeshi population living in East London: A cross‐sectional study

Vitamin D deficiency and atopic dermatitis severity in a Bangladeshi population living in East London: A cross‐sectional study

Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis

Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases

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