Oral vitamin C treatment increases polymorphonuclear cell functions in type 2 diabetes mellitus patients with poor glycemic control

Chuangchot, Nisa; Boonthongkaew, Chongchira; Phoksawat, Wisitsak; Jumnainsong, Amonrat; Leelayuwat, Chanvit; Leelayuwat, Naruemon

doi:10.1016/j.nutres.2020.05.010

Cited by 5 publications

(6 citation statements)

References 29 publications

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“…The main role of vitamin C in infectious diseases is related to its function in the (i) stimulation of the neutrophil migration into the site of infection, (ii) enhancement of the phagocytosis and oxidant production, and (iii) elimination of microbial germs [ 100 ]. Vitamin C through increasing neutrophil apoptosis and macrophage clearance, decreasing neutrophil necrosis can protect from extreme host tissue damages [ 65 ].…”

Section: Vitamins and Minerals In The Immune Functionmentioning

confidence: 99%

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19

et al. 2021

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The escalating prevalence of coronavirus disease 2019 (COVID-19) worldwide, with an increased rate of morbidity and mortality, highlights an urgent need to develop more effective therapeutic interventions. Despite the authorized treatment against COVID-19 by the European Union (EU), the safety and effectiveness of this therapeutic strategy for a wide variety of patients have remained a significant challenge. In this respect, micronutrients such as vitamins and minerals, as essential factors, can be considered for improving the function of the immune system and accelerating the treatment procedure. Dietary supplements can attenuate vascular and inflammatory manifestations related to infectious diseases in large part due to their anti-inflammatory and antioxidant properties. Recently, it has been revealed that poor nutritional status may be one of the notable risk factors in severe COVID-19 infections. In the current review, we focus on the micronutrient therapy of COVID-19 patients and provide a comprehensive insight into the essential vitamins/minerals and their role in controlling the severity of the COVID-19 infection. We also discuss the recent advancements, challenges, negative and positive outcomes in relevance to this approach.

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Section: Vitamins and Minerals In The Immune Functionmentioning

confidence: 99%

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19

et al. 2021

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“…Vitamin C supports the activity of some components of innate and adaptive immunity (81,82) , as well as the physical barriers that limit entry to pathogens (83) and helps to control oxidative stress and inflammation. Vitamin C supplementation improves some markers of immunity especially in older people (84,85) and a meta-analysis (86) suggests that those under physical or physiological stress may show reduced incidence and duration of the common cold with vitamin C supplementation, especially if 'high' doses are used. Several studies report an association between low vitamin C status and increased susceptibility to, and severity of, COVID-19 (87,88) .…”

Section: Many Nutrients Are Important In Supporting the Immune System...mentioning

confidence: 99%

Nutrition and immunity: lessons from coronavirus disease-2019

Calder

2023

Proc. Nutr. Soc.

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This review will provide an overview of the immune system and then describe the effects of frailty, obesity, specific micronutrients and the gut microbiota on immunity and susceptibility to infection including data from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic where relevant. A key role for the immune system is providing host defence against pathogens. Impaired immunity predisposes to infections and to more severe infections and weakens the response to vaccination. A range of nutrients, including many micronutrients, play important roles in supporting the immune system to function. The immune system can decline in later life and this is exaggerated by frailty. The immune system is also weakened with obesity, generalised undernutrition and micronutrient deficiencies, which all result in increased susceptibility to infection. Findings obtained during the SARS-CoV-2 pandemic support what was already known about the effects of ageing, frailty and obesity on immunity and susceptibility to infection. Observational studies conducted during the pandemic also support previous findings that multiple micronutrients including vitamins C, D and E, zinc and selenium and long-chain n-3 fatty acids are important for immune health, but whether these nutrients can be used to treat those already with coronavirus disease discovered in 2019 (COVID-19), particularly if already hospitalised, is uncertain from current inconsistent or scant evidence. There is gut dysbiosis in patients with COVID-19 and studies with probiotics report clinical improvements in such patients. There is an inverse association between adherence to a healthy diet and risk of SARS-CoV-2 infection and hospitalisation with COVID-19 which is consistent with the effects of individual nutrients and other dietary components. Addressing frailty, obesity and micronutrient insufficiency will be important to reduce the burden of future pandemics and nutritional considerations need to be a central part of the approach to preventing infections, optimising vaccine responses and promoting recovery from infection.

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“…Chuangchot et al [28] have investigated the effects of vitamin C on the functions of polymorphonuclear cells (PMNs) in poorly controlled type 2 diabetics. They theorized that oral L-ascorbic acid supplementation further develops PMN cell capabilities.…”

Section: Rtcs On Vitamin D In Prevention Of Type 2 Diabetesmentioning

confidence: 99%

“…The hazard ratio for the intervention was reported to be 0.9, showing that there was no huge relationship between vitamin D supplementation and type 2 diabetes risk in this populace. Members were beyond 38 years old a review that was done in the US [28]. The treatment consisted of receiving 6,000 IU of vitamin C daily for two years.…”

Section: Meta Analysis Of Rct Studiesmentioning

confidence: 99%

Exploring The Link Between Vitamin D and Type 2 Diabetes Prevention: A Comprehensive Meta-Analysis of Observational Studies

Sridevi,

Raghunatha Rao

2023

J. Adv. Zool.

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Albeit the reasonableness of vitamin D supplementation in lessening unmistakable diabetes stays muddled, vitamin D has arisen as a huge indicator of progress in type 2 diabetes. We played out a thorough meta-examination that included hybrid investigations and controlled preliminaries randomly chosen to account for this uncertainty. Our findings add to the ongoing discussion surrounding this issue and provide useful information regarding the possibility that vitamin D plays a role in the treatment of type 2 diabetes. In this systematic review, we wanted to provide a comprehensive overview of the most recent data on the effects of vitamin D on people with type 2 diabetes. We searched multiple databases in accordance with PRISMA guidelines and found 40 relevant studies published between 2015 and 2022. may make the disease more likely to happen to you. However, other considerations, such as one's lifestyle, diet, and genetic predisposition to type 2 diabetes, are essential. Conversely, our meta-investigation of randomized clinical preliminaries found that vitamin D supplementation didn't fundamentally lessen the gamble of creating type 2 diabetes. According to these findings, supplementing vitamin D levels may not be sufficient to stop disease progression. The individual and the underlying pathophysiology of the disease may determine how Diabetes type 2 can be fought with vitamin D. Basically the survey takes a better reaching evaluation of the nowadays information on the types of diabetes with the connection. More exploration is expected to all the more likely comprehend the components in question and to investigate extra preventive methodologies and mediations for type 2 diabetes.

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Oral vitamin C treatment increases polymorphonuclear cell functions in type 2 diabetes mellitus patients with poor glycemic control

Cited by 5 publications

References 29 publications

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19

Nutrition and immunity: lessons from coronavirus disease-2019

Exploring The Link Between Vitamin D and Type 2 Diabetes Prevention: A Comprehensive Meta-Analysis of Observational Studies

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