Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs

Foster, Neil; Richards, Luke; Higgins, John P.; Kanellos, Theo; Barrow, Paul

doi:10.1016/j.rvsc.2015.12.013

Cited by 2 publications

(1 citation statement)

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“…S. Typhimurium 14028 is virulent in mice (28) and in ex vivo human monocytes (29). S. Typhimurium 4/74 was originally isolated from a diseased calf and is highly virulent for pigs (30,31) and in ex vivo human monocytes (32). S. Choleraesuis A50 was isolated from diseased pigs and is virulent in vivo (30) and in ex vivo systems (33).…”

Section: Methodsmentioning

confidence: 99%

Differential Immune Phenotypes in Human Monocytes Induced by Non-Host-Adapted Salmonella enterica Serovar Choleraesuis and Host-AdaptedS. Typhimurium

et al. 2018

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We studied the effects of two serovar Typhimurium (host-adapted) strains (14028 and 4/74) and three Choleraesuis (non-host-adapted) strains (A50, A45, and B195) in human monocytes between 2 and 24 h postinfection (p.i.) to investigate whether differences in immune response may explain the much higher prevalence of sepsis in individuals infected with Choleraesuis. Both serovars significantly increased the production of cytokines associated with acute sepsis (tumor necrosis factor alpha [TNF-α], interleukin β [IL-β], and IL-6), but temporal differences occurred between these serovars and between different Choleraesuis strains. Generally, all Choleraesuis strains induced significantly higher production of inflammatory cytokines than Typhimurium strains (P < 0.01 to 0.05). All Choleraesuis strains very significantly increased IL-10 production by monocytes at 6 and 24 h p.i. in comparison to Typhimurium strains ( < 0.01). In addition, ∼80% of monocytes were viable at 24 h p.i. with Choleraesuis A50, compared to only ∼40% following Typhimurium infection. Using Typhimurium 14028 and Choleraesuis A50 as examples of these two serovars, we also showed differential expression of genes within the Janus tyrosine kinase (JAK) and signal transducer and activator of transcription (STAT) (JAK/STAT) pathway via quantitative PCR (qPCR) microarray analysis. High serum IL-10 concentration and monocyte survival have been reported as markers of the development of human sepsis. We therefore conclude that high production of IL-10 by monocytes may, in part, explain the greater propensity for Choleraesuis to induce human sepsis and that this may be greater in strains such as A50, which induces both high IL-10 production and monocyte survival.

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Section: Methodsmentioning

confidence: 99%

Differential Immune Phenotypes in Human Monocytes Induced by Non-Host-Adapted Salmonella enterica Serovar Choleraesuis and Host-AdaptedS. Typhimurium

et al. 2018

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Release of HMGB1 and Toll-like Receptors 2, 4, and 9 Signaling Are Modulated by Bifidobacterium animalis subsp. lactis BB-12 and Salmonella Typhimurium in a Gnotobiotic Piglet Model of Preterm Infants

Šplı́chal

Donovan

Kindlova

et al. 2023

IJMS

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Gnotobiotic (GN) animals with defined microbiota allow us to study host–microbiota and microbiota–microbiota interferences. Preterm germ-free (GF) piglets were mono-associated with probiotic Bifidobacterium animalis subsp. lactis BB-12 (BB12) to ameliorate/prevent the consequences of infection with the Salmonella Typhimurium strain LT2 (LT2). Goblet cell density; expression of Toll-like receptors (TLRs) 2, 4, and 9; high mobility group box 1 (HMGB1); interleukin (IL)-6; and IL-12/23p40 were analyzed to evaluate the possible modulatory effect of BB12. BB12 prevented an LT2-induced decrease of goblet cell density in the colon. TLRs signaling modified by LT2 was not influenced by the previous association with BB12. The expression of HMGB1, IL-6, and IL12/23p40 in the jejunum, ileum, and colon and their levels in plasma were all decreased by BB12, but these changes were not statistically significant. In the colon, differences in HMGB1 distribution between the GF and LT2 piglet groups were observed. In conclusion, the mono-association of GF piglets with BB12 prior to LT2 infection partially ameliorated the inflammatory response to LT2 infection.

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Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs

Cited by 2 publications

References 36 publications

Differential Immune Phenotypes in Human Monocytes Induced by Non-Host-Adapted Salmonella enterica Serovar Choleraesuis and Host-AdaptedS. Typhimurium

Differential Immune Phenotypes in Human Monocytes Induced by Non-Host-Adapted Salmonella enterica Serovar Choleraesuis and Host-AdaptedS. Typhimurium

Release of HMGB1 and Toll-like Receptors 2, 4, and 9 Signaling Are Modulated by Bifidobacterium animalis subsp. lactis BB-12 and Salmonella Typhimurium in a Gnotobiotic Piglet Model of Preterm Infants

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