Oral vaccination and protection of striped skunks (Mephitis mephitis) against rabies using ONRAB®

Brown, L.; Rosatte, Rick; Fehlner-Gardiner, Christine; Ellison, James A.; Jackson, Felix R.; Bachmann, Peter; Taylor, J.S.; Franka, Richard; Donovan, Dennis M.

doi:10.1016/j.vaccine.2014.04.029

Cited by 36 publications

(19 citation statements)

References 29 publications

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“…ONRAB protected captive skunks from rabies in an efficacy study [67] and also in a high density field application that eliminated the arctic fox variant from free-ranging skunks in Ontario [43]. However, results from other studies are contradictory because free-ranging skunks still demonstrate low population immunity in response to more commonly used ORV bait application densities (Table 1) [24, 50, 51, 68], which complicates management efforts because skunks are susceptible to spillover of raccoon rabies [11].…”

Section: Rabies Management Strategiesmentioning

confidence: 99%

Management and modeling approaches for controlling raccoon rabies: The road to elimination

et al. 2017

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Rabies is an ancient viral disease that significantly impacts human and animal health throughout the world. In the developing parts of the world, dog bites represent the highest risk of rabies infection to people, livestock, and other animals. However, in North America, where several rabies virus variants currently circulate in wildlife, human contact with the raccoon rabies variant leads to the highest per capita population administration of post-exposure prophylaxis (PEP) annually. Previous rabies variant elimination in raccoons (Canada), foxes (Europe), and dogs and coyotes (United States) demonstrates that elimination of the raccoon variant from the eastern US is feasible, given an understanding of rabies control costs and benefits and the availability of proper tools. Also critical is a cooperatively produced strategic plan that emphasizes collaborative rabies management among agencies and organizations at the landscape scale. Common management strategies, alone or as part of an integrated approach, include the following: oral rabies vaccination (ORV), trap-vaccinate-release (TVR), and local population reduction. As a complement, mathematical and statistical modeling approaches can guide intervention planning, such as through contact networks, circuit theory, individual-based modeling, and others, which can be used to better understand and predict rabies dynamics through simulated interactions among the host, virus, environment, and control strategy. Strategies derived from this ecological lens can then be optimized to produce a management plan that balances the ecological needs and program financial resources. This paper discusses the management and modeling strategies that are currently used, or have been used in the past, and provides a platform of options for consideration while developing raccoon rabies virus elimination strategies in the US.

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Section: Rabies Management Strategiesmentioning

confidence: 99%

Management and modeling approaches for controlling raccoon rabies: The road to elimination

et al. 2017

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“…Adenoviruses can be easily manipulated for the incorporation of genes encoding desired immunogens for the production of vaccine vectors (Tatsis & Ertl, ). ONRAB ® , a live, recombinant adenovirus expressing the RABV glycoprotein, has been employed as a bait vaccine that has contributed to the successful protection of species such as red foxes, striped skunks and raccoons against rabies in Canada (Brown et al, ,; Fehlner‐Gardiner et al, ).…”

Section: Success Of Wildlife Rabies Vaccination Campaigns: Vaccine Vementioning

confidence: 99%

“…Adenovirus vectors have also been shown to be highly immunogenic, with the ability to induce strong humoral and cell‐mediated immune responses, such as neutralizing antibodies and CD8 T cell responses, respectively (Braucher et al, ; Brown et al, ; Hu et al, ; Priddy et al, ; Smaill et al, ; F. Zhu et al, ). Adenovirus‐vectored vaccines demonstrate immunogenicity and protective efficacy when administered via the oral route (Deng et al, ; Xiang et al, ).…”

Section: Success Of Wildlife Rabies Vaccination Campaigns: Vaccine Vementioning

confidence: 99%

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Baited vaccines: A strategy to mitigate rodent‐borne viral zoonoses in humans

Mendoza

Warner

Kobinger

et al. 2018

Zoonoses and Public Health

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Rodents serve as the natural reservoir and vector for a variety of pathogens, some of which are responsible for severe and life-threatening disease in humans. Despite the significant impact in humans many of these viruses, including Old and New World hantaviruses as well as Arenaviruses, most have no specific vaccine or therapeutic to treat or prevent human infection. The recent success of wildlife vaccines to mitigate rabies in animal populations offers interesting insight into the use of similar strategies for other zoonotic agents of human disease. In this review, we discuss the notion of using baited vaccines as a means to interrupt the transmission of viral pathogens between rodent reservoirs and to susceptible human hosts.

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“…Adenovirus vectors have been extensively tested as vaccine delivery systems in several pre‐clinical and clinical studies for a number of infectious diseases including rabies [6–8], human immunodeficiency virus 1 (HIV‐1) [9, 10], malaria [11–13], hepatitis C virus (HCV) [10, 14], and influenza [15–17]. Adenovirus vectors are also used as therapeutic cancer vaccines by enabling the immune system to recognize cancer cells and influence their growth or lead to their suppression.…”

Section: Introductionmentioning

confidence: 99%

Large‐scale adenovirus and poxvirus‐vectored vaccine manufacturing to enable clinical trials

Kallel

Kamen

2015

Biotechnology Journal

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Efforts to make vaccines against infectious diseases and immunotherapies for cancer have evolved to utilize a variety of heterologous expression systems such as viral vectors. These vectors are often attenuated or engineered to safely deliver genes encoding antigens of different pathogens. Adenovirus and poxvirus vectors are among the viral vectors that are most frequently used to develop prophylactic vaccines against infectious diseases as well as therapeutic cancer vaccines. This mini-review describes the trends and processes in large-scale production of adenovirus and poxvirus vectors to meet the needs of clinical applications. We briefly describe the general principles for the production and purification of adenovirus and poxvirus viral vectors. Currently, adenovirus and poxvirus vector manufacturing methods rely on well-established cell culture technologies. Several improvements have been evaluated to increase the yield and to reduce the overall manufacturing cost, such as cultivation at high cell densities and continuous downstream processing. Additionally, advancements in vector characterization will greatly facilitate the development of novel vectored vaccine candidates.

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Oral vaccination and protection of striped skunks (Mephitis mephitis) against rabies using ONRAB®

Cited by 36 publications

References 29 publications

Management and modeling approaches for controlling raccoon rabies: The road to elimination

Management and modeling approaches for controlling raccoon rabies: The road to elimination

Baited vaccines: A strategy to mitigate rodent‐borne viral zoonoses in humans

Large‐scale adenovirus and poxvirus‐vectored vaccine manufacturing to enable clinical trials

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