Oral ulcerations due to drug medications

Jinbu, Yoshinori; Demitsu, Toshio

doi:10.1016/j.jdsr.2013.12.001

Cited by 49 publications

(44 citation statements)

References 44 publications

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“…The underlying mechanism of drug-induced ulceration is often unclear, and histopathological examination usually reveals nonspecific ulcer formation with marked infiltration as inflammatory cells. 18 Our patient complained of subacute onset of dysphonia and videolaryngoscopic images of larynx showed a picture resembling a supraglottic carcinoma characterized by the presence of dysphonia and dysphagia. The history of inhaled corticosteroid therapy let us to suspect mycotic laryngitis mimicking a malignant process.…”

Section: Discussionmentioning

confidence: 58%

Laryngeal Candidiasis Mimicking Supraglottic Carcinoma by Prolonged Inhaled Steroid Therapy: A Case Report and Review of the Literature

et al. 2020

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Candidiasis is a rare entity reported as an isolated and primary laryngeal disease. In this condition, inhaled steroids were the single most common predisposing factor. Also mycotic infections of larynx are frequently seen in patients with immune insufficiency, although they have also been reported in individual with normal immune status. We report a case of isolated laryngeal Candidiasis in an immunocompetent individual, with an unusual presentation with exophytic lesion, edema, ulceration, white plaque, and pseudomembranous formation mimicking supraglottic carcinoma, to highlight the clinical of this condition and provide a review of the literature.

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Section: Discussionmentioning

confidence: 58%

Laryngeal Candidiasis Mimicking Supraglottic Carcinoma by Prolonged Inhaled Steroid Therapy: A Case Report and Review of the Literature

et al. 2020

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“…Oral Ulcerative and Vesiculo-bullous lesions Clinically, there are 2 types of drug-induced oral ulcers (20): The first is widespread mucositis and ulceration, the culprit of which is anti-tumor chemotherapy. Although several cancer therapeutic modalities are growing (21), anti-tumor chemotherapy with cytotoxic drugs is the most accepted modality.…”

Section: Xerostomia and Hyposalivationmentioning

confidence: 99%

“…The second type is fixed drug eruption, with the manifestation of recurrent treatment-resistant ulcers (20). Fixed drug eruption ulcerations can appear on every site of the oral mucosa.…”

Section: Xerostomia and Hyposalivationmentioning

confidence: 99%

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An Update on Drug-induced Oral Reactions

Yousefi¹,

Abdollahi²

2018

J Pharm Pharm Sci

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-Adverse drug reactions (ADRs) are one of the major culprits in the development of oral lesions, which can be misdiagnosed with underlying diseases. The goal of this study is to summarize and update the current knowledge about drug-induced oral reactions. Electronic searches were performed in Scopus, Google Scholar, Cochrane and PubMed databases, for articles published between January 2008 and August 2017. Two authors screened the titles and abstracts for eligibility. Finally, 56 studies included in this review. There was no systematic homogeneity in the included studies; thereby no meta-analysis was performed. The most frequent oral ADR was xerostomia, and the most reported cause was antihypertensive medications. Cardiovascular drugs were the most reported culprit agents for induction of oral ulcerative and vesiculo-bullous lesions, followed by methotrexate. Nonsteroidal anti-inflammatory drugs (NSAIDs) and β-blockers were found the most common responsible drugs for induction of oral lichen planus.

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“…clindamycin, isoniazid, penicillin and sulphonamides), angiotension II receptor antagonists, antidepressants and anti-HIV drugs [71][72][73][74]. The key feature of drug-induced oral ulceration is that it does not respond to topical steroid therapy [75][76][77][78]. Choosing an alternate drug or decreasing the dosage has been reported to cause remission of the lesion [79].…”

Section: Oral Ulcerationmentioning

confidence: 99%

Adverse drug reactions in the oral cavity

Sivaramakrishnan

Sridharan

2016

Drugs Ther Perspect

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Drugs prescribed for various systemic disorders have become a boon in increasing life span over the recent years, but are not without adverse effects. As regards to the oral cavity, the drug-related adverse effects include hard and soft tissue alterations, such as tooth or soft tissue discolouration, abnormal tooth movement, gingival overgrowth, oral ulceration, halitosis, abnormal salivary flow, etc. The use of alternative medications or temporarily avoiding the use of the drug might cause regression or stop the progression of the adverse effects. This narrative review aims to identify all the major hard and soft tissue manifestations produced by drugs in the oral cavity, the drugs causing them and their prevention and treatment.

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Oral ulcerations due to drug medications

Cited by 49 publications

References 44 publications

Laryngeal Candidiasis Mimicking Supraglottic Carcinoma by Prolonged Inhaled Steroid Therapy: A Case Report and Review of the Literature

Laryngeal Candidiasis Mimicking Supraglottic Carcinoma by Prolonged Inhaled Steroid Therapy: A Case Report and Review of the Literature

An Update on Drug-induced Oral Reactions

Adverse drug reactions in the oral cavity

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