Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: A systematic review and meta-analysis of randomized controlled trials

White, C Michael; Pasupuleti, Vinay; Roman, Yuani M.; Li, Yangzhou; Hernandez, Adrián V.

doi:10.1016/j.phrs.2019.104280

Cited by 92 publications

(59 citation statements)

References 34 publications

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“…Chronic inflammation has been shown to cause cardiovascular disease, and curcumin can prevent these diseases [ 55 ]. The results of this study can be examined in the people who suffer from cardiovascular dysfunction as a result of systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats

Ahmadabady

Beheshti

Shahidpour

et al. 2021

Biochemistry and Biophysics Reports

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Section: Discussionmentioning

confidence: 99%

A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats

Ahmadabady

Beheshti

Shahidpour

et al. 2021

Biochemistry and Biophysics Reports

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“…1 Future potential therapies that are under investigation run the gamut from the inexpensive curcumin extract of turmeric and hydroxychloroquine to novel drug targets, such as phospholipase A2 inhibitors, 5-lipoxygenase inhibitors, and Activin, that would be much more expensive. 17,18 However, these drugs have not been studied in major clinical trials, so their impact on final health outcomes and the balance of benefit to harm is not known. This review adds unique value to the clinician because it summarizes major clinical trials assessing the adjuvant use of the anti-inflammatory drugs colchicine, canakinumab, and methotrexate.…”

Section: Relevance To Patient Care and Clinical Practicementioning

confidence: 99%

The Role of Suppressing Inflammation in the Treatment of Atherosclerotic Cardiovascular Disease

2020

Self Cite

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Objective:To review the 3 anti-inflammatory drugs, canakinumab, colchicine, and methotrexate, that have been investigated in major clinical trials for treating patients with atherosclerotic cardiovascular disease (ASCVD). Data Sources: An Ovid MEDLINE literature search (1946 to February 2, 2020) was performed using search strategy [( C-reactive protein OR ASCVD OR cardiac disease OR cardiovascular disease) AND (canakinumab OR methotrexate OR Colchicine)]. Additional references were identified from the citations. Study Selection and Data Extraction: English-language studies assessing the impact of these 3 drugs on inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) or the association with reducing ASCVD events were included. Data Synthesis: Canakinumab and colchicine significantly reduced ASCVD events in high-risk patients with median baseline hs-CRP levels of ~4.0 mg/L. Methotrexate was ineffective at reducing ASCVD events in high-risk patients, but their baseline hs-CRP concentrations were a median of <2 mg/L. In subgroup analyses of the Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS), patients whose baseline hs-CRP was 2 to 4 mg/L had benefits from canakinumab therapy similar to those with baseline levels exceeding 4. Relevance to Patient Care and Clinical Practice: Even with the best current drug therapies, patients with underlying inflammation can benefit from the addition of both colchicine and canakinumab to further lower CV events. Given its cost, colchicine is a more attractive option. Conclusions: Patients at high risk of recurrent cardiovascular disease events with an hs-CRP of 2 mg/L or greater can reduce the occurrence of ASCVD events with canakinumab or colchicine therapy. Colchicine is the preferable option, in particular for those with myocardial infarction, given its more reasonable cost.

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“…Además los aceites volátiles de la cúrcuma son compuestos terpenoides, que brindan ese aroma terroso característico de la cúrcuma como se observa en la Figura 2 , dentro de estos compuestos terpenoides se encuentran una gran variedad de sesquiterpenos cetónicos como son la ar-turmerona que se encuentra en un máximo de 25% , los isómeros α-turmerona y β-turmerona en un máximo del 30% y zingibireno en un máximo de un 25%, en su totalidad muestran propiedades antioxidantes (128) (126) (129) , además la cúrcuma también contiene otros componentes no curcumina como tumerina, furanodieno, calebina A, entre otras, que también han demostrado en estudios animales actividad antiinflamatoria (130) . Col. 2016.…”

Section: Composición Y Estructura Químicaunclassified

“…Aunque el componente antiinflamatorio más conocido del Turmérico es la curcumina, también se conocen de componentes no curcumina. Entre ellas se encuentran compuestos como tumerina, furanodieno, calebina A, ciclocurcumina, entre otras, que también han demostrado en estudios animales actividad antiinflamatoria (130) .…”

Section: Aspecto Metabólicounclassified

“…A diferencia de Tabrizi R. , White M.C. (330) y colaboradores en su revisión sistemática y meta-análisis del consumo oral de cúrcuma y curcumina en los marcadores inflamatorios en enfermedades crónicas inflamatorias, no observó disminución significativa en los niveles de proetína c reactiva. Sin embargo, en la presente revisión también se observó disminución significativa de los niveles de proteina c reactiva (p<0,01, p<0,001), en el cincuenta por ciento de los artículos incluidos, en pacientes diabéticos y con NAFLD.…”

Section: Curcuminaunclassified

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Efecto de la cúrcuma y té verde sobre el riesgo cardiometabólico. Revisión sistemática

Medina¹,

Lorena²

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Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: A systematic review and meta-analysis of randomized controlled trials

Cited by 92 publications

References 34 publications

A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats

A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats

The Role of Suppressing Inflammation in the Treatment of Atherosclerotic Cardiovascular Disease

Efecto de la cúrcuma y té verde sobre el riesgo cardiometabólico. Revisión sistemática

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