Oral treatments with a flavonoid-enriched fraction from Cecropia hololeuca and with rutin reduce articular pain and inflammation in murine zymosan-induced arthritis

Teixeira, F.M.; Coelho, Mariana N.; José-Chagas, Fernanda do Nascimento; Malvar, David do Carmo; Kanashiro, Alexandre; Cunha, Fernando de Queiróz; Vianna-Filho, Marcelo Dias Machado; Pinto, Ângelo da Cunha; Vanderlinde, Frederico Argollo; Costa, Sônia Soares

doi:10.1016/j.jep.2020.112841

Cited by 19 publications

(14 citation statements)

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“…Rutin has also been investigated due to its beneficial effects on the strengthening of blood vessels and arteries [51], as well during the chronic condition of arthritis, as it can ease the flexibility of the veins [52]. Rutin has also been used for several pharmacological applications, including as a model drug, due to its antifungal, antiviral, and anti-inflammatory properties [53][54][55].…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

Shafreen¹,

Lakshmi

Pandian

et al. 2021

Molecules

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Previous reports have shown that consumption of wine has several health benefits; however, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candidates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications.

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Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

Shafreen¹,

Lakshmi

Pandian

et al. 2021

Molecules

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“…They are the main metabolites of flavonoids in ARF. They have been reported to have significant anti-RA effects ( Adhikary et al, 2018 ; Teixeira et al, 2020 ). Therefore, based on the idea of ARF playing a role as a whole, rutin and isoquercitrin were also selected as the main constituents to promote the investigation of treatment target prediction and validation of ARF on RA.…”

Section: Discussionmentioning

confidence: 99%

Gaultheria leucocarpa var. yunnanensis for Treating Rheumatoid Arthritis—An Assessment Combining Machine Learning–Guided ADME Properties Prediction, Network Pharmacology, and Pharmacological Assessment

et al. 2021

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Background: Dianbaizhu (Gaultheria leucocarpa var. yunnanensis), a traditional Chinese/ethnic medicine (TC/EM), has been used to treat rheumatoid arthritis (RA) for a long time. The anti–rheumatic arthritis fraction (ARF) of G. yunnanensis has significant anti-inflammatory and analgesic activities and is mainly composed of methyl salicylate glycosides, flavonoids, organic acids, and others. The effective ingredients and rudimentary mechanism of ARF remedying RA have not been elucidated to date.Purpose: The aim of the present study is to give an insight into the effective components and mechanisms of Dianbaizhu in ameliorating RA, based on the estimation of the absorption, distribution, metabolism, and excretion (ADME) properties, analysis of network pharmacology, and in vivo and in vitro validations.Study design and methods: The IL-1β–induced human fibroblast-like synoviocytes of RA (HFLS-RA) model and adjuvant-induced arthritis in the rat model were adopted to assess the anti-RA effect of ARF. The components in ARF were identified by using UHPLC-LTQ-Orbitrap-MSn. The quantitative structure–activity relationship (QSAR) models were developed by using five machine learning algorithms, alone or in combination with genetic algorithms for predicting the ADME properties of ARF. The molecular networks and pathways presumably referring to the therapy of ARF on RA were yielded by using common databases and visible software, and the experimental validations of the key targets conducted in vitro.Results: ARF effectively relieved RA in vivo and in vitro. The five optimized QSAR models that were developed showed robustness and predictive ability. The characterized 48 components in ARF had good biological potency. Four key signaling pathways were obtained, which were related to both cytokine signaling and cell immune response. ARF suppressed IL-1β–induced expression of EGFR, MMP 9, IL2, MAPK14, and KDR in the HFLS-RA .Conclusions: ARF has good druggability and high exploitation potential. Methyl salicylate glycosides and flavonoids play essential roles in attuning RA. ARF may partially attenuate RA by regulating the expression of multi-targets in the inflammation–immune system. These provide valuable information to rationalize ARF and other TC/EMs in the treatment of RA.

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“…Logo, compostos com potencial analgésico e antiinflamatório conseguem reduzir a resposta dolorosa causada pelo ácido. Todos os solventes apresentaram redução significativa da dor, e isso pode estar atrelado à presença de compostos fenólicos, em especial dos flavonoides, que já são bem reportados modulando o processo inflamatório e analgésico (TEIXEIRA et al, 2020;NAYEEM et al, 2022) e os terpenos (CARVALHO et al, 2019).…”

Section: Discussionunclassified

Avaliação De Diferentes Extratos Da Casca De Annona Squamosa Para Potencial Analgésico

et al. 2022

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Plantas medicinais são cada vez mais investigadas no intuito de encontrar compostos de interesse biotecnológico. Nesse contexto, partes pouco utilizadas de plantas reportadas como medicinais são de alto interesse para bioprospecção e sustentabilidade. Pinha, Annona squamosa, é uma planta frutífera bem utilizada no Brasil e se enquadra nesse perfil. Com isso, o objetivo deste estudo foi comparar a extração de compostos da casca da pinha por diversos solventes e avaliar qual possui melhor atividade analgésica. Pinhas foram coletadas no município de Recife, PE, e o pó da casca foi submetido a extração por água, metanol, acetato de etila, clorofórmio e ciclohexano. Foi realizada triagem para identificação de vários metabólitos primários e secundários e foi realizado teste de analgésico para confirmação do potencial biológico. O rendimento foi de acordo com o grau de polaridade do extrato, extratos com maior polaridade apresentaram maior rendimento. Além disso, os extratos aquoso e metanólico apresentaram maior variedade de constituintes e maior potencial analgésico, pouco mais de 50 %. Água e Metanol se mostraram eficientes na extração de compostos de interesse medicinal da casca da pinha. Destes, a água é tida como o solvente de melhor escolha, tendo em vista o risco de toxicidade causada pelo metanol.

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Oral treatments with a flavonoid-enriched fraction from Cecropia hololeuca and with rutin reduce articular pain and inflammation in murine zymosan-induced arthritis

Cited by 19 publications

References 67 publications

In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

Gaultheria leucocarpa var. yunnanensis for Treating Rheumatoid Arthritis—An Assessment Combining Machine Learning–Guided ADME Properties Prediction, Network Pharmacology, and Pharmacological Assessment

Avaliação De Diferentes Extratos Da Casca De Annona Squamosa Para Potencial Analgésico

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