Oral Treatment of Keloids

Treatment of Inflamed Hypertrophic Scars Using Intralesional 5-FU

“…A variety of treatment regimens have been used in keloids and hypertrophic scars with uncertain results achieved. 2,[10][11][12][13][14][15][16][17][18][19] In the early 1980s, 5-fluorouracil (5-FU), a pyrimidine analog with antimetabolite activity, was investigated as an adjunct to glaucoma filtering surgery, a procedure in which inhibition of wound healing is desirable to achieve surgical success. [20][21][22][23] This drug has been shown to inhibit fibroblast proliferation in tissue culture 24 and is believed to reduce postoperative scarring by decreasing fibroblast proliferation.…”

Treatment of Keloid with Asiaticoside

“…Regarding the oral treatment of keloid by tctrahydroxyquinone, Kelley and Pinkus [7] concluded that this treatment is tedious and slow and the effect is in complete in large lesions. There is an undesirable reaction, which is the breakdown of keloid tissue accompanied by discharge of necrotic material.…”

Acne Keloidalis Nuchae is Scar and Keloid Formation Secondary to Mechanically Induced Folliculitis

“…15 Together, the higher chances of more intense inflammation and easier keloid formation may lead to a significantly higher incidence of AKN in black skin. It has been well established that the follicular inflammatory disorders of dissecting cellulitis, folliculitis Letter to the Editor decalvans, and central centrifugal scarring alopecia occur more commonly in this group.…”