Oral Topiramate Reduces the Consequences of Drinking and Improves theQuality of Life of Alcohol-Dependent Individuals

Johnson, Bankole A.; Ait-Daoud, Nassima; Akhtar, Fatema Z.; Jennie, Z.

doi:10.1001/archpsyc.61.9.905

Cited by 152 publications

(97 citation statements)

References 30 publications

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“…In addition, preclinical studies and knowledge of the drug's unique mechanisms of action support the notion that topiramate can also reduce withdrawal symptoms, prevent relapse, and promote long-term abstinence, suggesting that topiramate may be useful as a 'harm-reduction strategy' in alcohol-dependent patients who cannot attain abstinence (Johnson et al, 2004a).…”

Section: Topiramatementioning

confidence: 93%

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Addolorato

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Hopf

et al. 2011

Neuropsychopharmacol

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Drug addiction represents a major social problem where addicts and alcoholics continue to seek and take drugs despite adverse social, personal, emotional, and legal consequences. A number of pharmacological compounds have been tested in human addicts with the goal of reducing the level or frequency of intake, but these pharmacotherapies have often been of only moderate efficacy or act in a sub-population of humans. Thus, there is a tremendous need for new therapeutic interventions to treat addiction. Here, we review recent interesting studies focusing on gamma-aminobutyric acid receptors, voltage-gated ion channels, and transcranial magnetic stimulation. Some of these treatments show considerable promise to reduce addictive behaviors, or the early clinical studies or pre-clinical rationale suggest that a promising avenue could be developed. Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism.

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Section: Topiramatementioning

confidence: 93%

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Addolorato

Leggio

Hopf

et al. 2011

Neuropsychopharmacol

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“…Currently there is no effective therapeutic agent without side effects for alcohol use disorder. Several drugs are available to treating the alcohol use disorder, such as disulfiram (aldehyde dehydrogenase inhibitor), naltrexone (opioid antagonist), topiramate (GABAergic anticonvulsant) and acamprosate (NMDA/glutamate receptor modulator) [97][98][99]. They can reduce voluntary alcohol intake and alcohol cravings.…”

Section: Natural Plants For Alcohol Use Disordermentioning

confidence: 99%

Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder

Wang

Zhang

et al. 2016

Molecules

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Alcoholic beverages such as beer, wine and spirits are widely consumed around the world. However, alcohol and its metabolite acetaldehyde are toxic and harmful to human beings. Chronic alcohol use disorder or occasional binge drinking can cause a wide range of health problems, such as hangover, liver damage and cancer. Some natural products such as traditional herbs, fruits, and vegetables might be potential dietary supplements or medicinal products for the prevention and treatment of the problems caused by excessive alcohol consumption. The aim of this review is to provide an overview of effective natural products for the prevention and treatment of hangover and alcohol use disorder, and special emphasis is paid to the possible functional component(s) and related mechanism(s) of action.

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“…Moreover, some studies have confirmed that QOL is lower in alcoholics, and varies with the severity of alcohol dependence [2,3]. Indeed, QOL tends to improve after detoxification and treatment [4][5][6][7][8] and worsen during relapse [6,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Based on this evidence, several studies have included QOL assessment as a measure of secondary outcome of alcohol detoxification programs [7,8,10,[12][13][14]. However, as reported in two recent reviews [15,16], two types of QOL assessment can be distinguished in addiction research: the Health-related Quality Of Life (HQOL) assessment focused on functional limitations due to illness and treatment; and the Overall Quality Of Life (OQOL) assessment, which takes into account both the objective well-being related to needs and desires common to most people and subjective satisfaction with life.…”

Section: Introductionmentioning

confidence: 99%

Quality of life, alcohol detoxification and relapse: Is quality of life a predictor of relapse or only a secondary outcome measure?

et al. 2014

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Oral Topiramate Reduces the Consequences of Drinking and Improves theQuality of Life of Alcohol-Dependent Individuals

Abstract: As an adjunct to medication compliance enhancement treatment, topiramate (up to 300 mg/d) was superior to placebo at not only improving drinking outcomes but increasing overall well-being and quality of life and lessening dependence severity and its harmful consequences.

Cited by 152 publications

References 30 publications

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder

Quality of life, alcohol detoxification and relapse: Is quality of life a predictor of relapse or only a secondary outcome measure?

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