Oral Tongue Squamous Cell Carcinoma in Never‐Smokers: Analysis of Clinicopathologic Characteristics and Survival

Durr, Megan L.; Zante, Annemieke van; Li, David; Kezirian, Eric J.; Wang, Steven J.

doi:10.1177/0194599813482876

Cited by 40 publications

(44 citation statements)

References 24 publications

(69 reference statements)

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“…Although OSCC is recognized as malignant neoplasm affecting mainly elderly patients, the incidence of OSCC in individuals under 45 years old has increased substantially within the past few years ( 4 - 7 , 10 , 12 , 16 ). Studies have suggested that OSCC develops a more aggressive behavior, with poor prognosis, among young patients ( 5 , 19 , 20 ). In this census study, the analysis of clinical records from two oncology referral hospitals in the northeast region Brazil has pointed out important risk factors implicated with the etiology and pathogenicity of OSCC among young individuals, resulting in a consistent epidemiological profile for this age group.…”

Section: Discussionmentioning

confidence: 99%

“…This fact may be associated high prevalence of OSCC at the lower lip (31.6%). Tumors affecting the tongue, the floor of the mouth and the lower lip have been included as the most frequent location on OSCC independently of age group ( 1 , 4 , 11 , 20 ). Furthermore, individuals with diagnostic of OSCC in the present study were predominantly men with low educational level.…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of OSCC is considered complex due to its multifactorial characteristic ( 4 , 8 , 10 , 11 , 15 , 16 , 20 - 27 ). Tobacco and alcohol consumption have been firmly stated as important risk factors for OSCC among elderly people.…”

Section: Discussionmentioning

confidence: 99%

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Clinical findings and risk factors to oral squamous cell carcinoma in young patients: A 12-year retrospective analysis

Santos

Santos²,

Paz³

et al. 2016

Med Oral

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BackgroundIn recent years have been observed an increased incidence of OSCC in young individuals. Based on this, the aim this study was to describe the clinical characteristics of all cases of OSCC in younger patients, diagnosed in two oncology referral hospitals, at the northeast region of Brazil within a 12-year period.Material and MethodsData regarding general characteristics of patients (age, gender and tobacco and/or alcohol habits) and information about the lesions (tumor location, size, regional lymph node metastasis, distant metastasis and clinical stage) were submitted to descriptive and inferential analysis. Statistical analysis included Chi-square and Fisher’s exact tests (P<0.05).ResultsOut of 2311 registered cases of OSCC, 76 (3.3%) corresponded to OSCC in patients under 45 years old. Most of them were male (n=62, 81.6%) and tobacco and/or alcohol users (n=40, 52.8%). The most frequent site was the tongue (n=31, 40.8%), with predominance of cases classified at advanced clinical stage (III and IV, n = 46, 60.5%). The advanced stage of OSCC (III and IV) was statistically associated with male gender (P=0.035), lower education level (P=0.007), intraoral site(P<0.001), presence of pain symptomatology (P=0.006), and consumption of tobacco and/or alcohol (P=0.001).ConclusionsThe profile of OSCC in young patients resembles to the commonly characteristics reported for overall population. The late diagnosis in young patients usually results in poor prognosis, associated with gender, harmful habits and tumor location. Although prevalence is low, stimulus to prevention and to early diagnosis should be addressed to young individuals exposed to risk factors. Key words:Squamous cell carcinoma, head and neck neoplasms, risk factors, young patients, prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical findings and risk factors to oral squamous cell carcinoma in young patients: A 12-year retrospective analysis

Santos

Santos²,

Paz³

et al. 2016

Med Oral

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“…The treatment of locally advanced head and neck tumors is site specific, depending on the exact origin site, depth of invasion, involvement of surrounding tissues, and regional and distal metastasis [1] . A primary therapeutic choice is synthetic serial treatment, with radical surgery emphasized [2] .…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging for Diagnosis of Mandibular Involvement from Head and Neck Cancers: A Systematic Review and Meta-Analysis

Yang

Men

et al. 2014

PLoS ONE

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BackgroundDiagnosis of mandibular involvement caused by head and neck cancers is critical for treatment. We performed a meta-analysis to determine the diagnostic efficacy of MR for distinguishing mandibular involvement caused by head and neck cancers.MethodsThirteen databases were searched electronically and hand-searching was also done. Two reviewers conducted study inclusion, data extractions, and quality assessment of the studies independently. Meta-disc 1.4 and STATA 11.0 were used to conduct the meta-analysis.Results16 studies involving a total of 490 participants underwent MR examinations and were accounted for in this meta-analysis. Among the included studies, 2 had high risk of bias, while the rest had unclear risk of bias. Meta-regression showed that the slight clinical and methodological heterogeneities did not influence the outcome (P>0.05). Meta-analysis indicated that the MR for the diagnosis of mandibular involvement had a pooled sensitivity (SEN) of 78%, specificity (SPE) of 83%, positive likelihood ratio (+LR) of 3.80, negative likelihood ratio (-LR) of 0.28, diagnostic odds ratio (DOR) of 28.94, area under curve (AUC) of 0.9110, and Q* of 0.8432. Two studies detected the diagnostic efficacy of MR for the mandibular medullar invasion, and only one study reported the inferior alveolar canal invasion, which made it impossible to include it in our meta-analysis. In comparing to CT, MR had a higher SEN without statistical significance (P = 0.08), but a significantly lower SPE (P = 0.04). The synthesized diagnostic efficacy (AUC and Q*) on mandibular involvement was similar between the two modalities (P>0.05).ConclusionsPresent clinical evidence showed that MR had an acceptable diagnostic value in detecting mandibular involvement caused by head and neck cancers. MR exceeded CT in diagnosing patients with mandibular invasion (higher sensitivity than CT) but was less efficacious to exclude patients without the mandibular invasion (lower specificity than CT).

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“…We recently reported that the never-smoking cohort may experience decreased survival and more aggressive characteristics than the smoking group [7–9]. However, it remains unclear what factors contribute to this poor clinical outcome [13].…”

Section: Introductionmentioning

confidence: 99%

Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient

et al. 2017

Self Cite

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Objective The rising incidence of oral tongue squamous cell carcinoma (OTSCC) in patients who have never smoked and the paucity of knowledge of its biological behavior prompted us to develop a new cell line originating from a never-smoker. Materials and methods Fresh tumor tissue of keratinizing OTSCC was collected from a 44-year-old woman who had never smoked. Serum-free media with a low calcium concentration were used in cell culture, and a multifaceted approach was taken to verify and characterize the cell line, designated UCSF-OT-1109. Results UCSF-OT-1109 was authenticated by STR DNA fingerprint analysis, presence of an epithelial marker EpCAM, absence of human papilloma virus (HPV) DNA, and SCC-specific microscopic appearance. Sphere-forming assays supported its tumorigenic potential. Spectral karyotype (SKY) analysis revealed numerical and structural chromosomal abnormalities. Whole-exome sequencing (WES) identified 46 non-synonymous and 13 synonymous somatic single-nucleotide polymorphisms (SNPs) and one frameshift deletion in the coding regions. Specifically, mutations of CDKN2A, TP53, SPTBN5, NOTCH2, and FAM136A were found in the databases. Copy number aberration (CNA) analysis revealed that the cell line loses chromosome 3p and 9p, but lacks amplification of 3q and 11q (as does HPV-negative, smoking-unrelated OTSCC). It also exhibits four distinctive focal amplifications in chromosome 19p, containing 131 genes without SNPs. Particularly, 52 genes showed >3- to 4-fold amplification and could be potential oncogenic drivers. Conclusion We have successfully established a novel OTSCC cell line from a never-smoking patient. UCSF-OT-1109 is potentially a robust experimental model of OTSCC in never-smokers.

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Oral Tongue Squamous Cell Carcinoma in Never‐Smokers: Analysis of Clinicopathologic Characteristics and Survival

Abstract: Overall survival may be decreased in never-smokers with OTSCC. Greater depth of tumor invasion and more advanced stage disease are associated with decreased survival. Perineural invasion and lymphovascular invasion are associated with disease recurrence.

Cited by 40 publications

References 24 publications

Clinical findings and risk factors to oral squamous cell carcinoma in young patients: A 12-year retrospective analysis

Clinical findings and risk factors to oral squamous cell carcinoma in young patients: A 12-year retrospective analysis

Magnetic Resonance Imaging for Diagnosis of Mandibular Involvement from Head and Neck Cancers: A Systematic Review and Meta-Analysis

Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient

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