Oral Tolerance Increased the Proportion of CD8+ T Cells in Mouse Intestinal Lamina Propria

Cho, Kyung‐Ah; Cha, Je-Eun; Woo, So Youn

doi:10.4110/in.2008.8.2.46

Cited by 2 publications

(2 citation statements)

References 21 publications

(14 reference statements)

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“…These features of oral mucosal vaccines make them attractive for mass immunization during pandemics [13]. However, one of the most significant problems associated with oral mucosal vaccines is possible tolerance induction against the orally introduced antigens, because it is generally known that oral administration of soluble proteins dominantly triggers oral tolerance [14,15]. To overcome this tolerogenic mucosal environment, many efforts have been made to develop effective mucosal adjuvants that can stimulate both innate and adaptive immunities and are capable of inducing effective mucosal and systemic immune responses.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticles from Plant Saponins as Delivery System for Mucosal Influenza Vaccine

Berezin¹,

Bogoyavlenskiy²,

Turmagambetova³

et al. 2013

AJIDM

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This article were studied nanoparticles assembled purified influenza virus hemagglutinin and neuraminidase antigens and low toxicity immunostimulating saponins Gg6 and Ah6, isolated from Kazakhstanian plants G.glabra and A.hippocastanum, in the animal vaccination/challenge experiments as delivery system for mucosal influenza subunit vaccine. Incorporation of influenza virus HA and NA antigens into the structure of nanoparticles significantly increased IgG, IgM and IgA antibody immune responses as well as production of IFNgamma and IL-2 after single intranasal immunization. Mucosal immunization with nanoparticles possessed HA+NA antigens and saponins Gg6 or Ah6 resulted much better protection of chickens against challenge of highly pathogenic H7N1 avian influenza virus in comparison with immunization of whole virus inactivated vaccine or vaccine mixed with alum hydroxide adjuvant.

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Section: Discussionmentioning

confidence: 99%

Nanoparticles from Plant Saponins as Delivery System for Mucosal Influenza Vaccine

Berezin¹,

Bogoyavlenskiy²,

Turmagambetova³

et al. 2013

AJIDM

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“…However, licensed mucosally administrable vaccines are available only for cholera, Type A and B influenza viruses, poliovirus, rotavirus, and Salmonella Typhi (9). One of the most significant problems associated with oral mucosal vaccines is possible tolerance induction against the orally introduced antigens, because it is generally known that oral administration of soluble proteins dominantly triggers oral tolerance (50,51). Tolerance induction by orally-introduced vaccine materials translates into systemic unresponsiveness after challenge infection by the same antigen.…”

Section: Mucosal Vaccinationmentioning

confidence: 99%

Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination

2012

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Vaccination is one of the most effective methods available to prevent infectious diseases. Mucosa, which are exposed to heavy loads of commensal and pathogenic microorganisms, are one of the first areas where infections are established, and therefore have frontline status in immunity, making mucosa ideal sites for vaccine application. Moreover, vaccination through the mucosal immune system could induce effective systemic immune responses together with mucosal immunity in contrast to parenteral vaccination, which is a poor inducer of effective immunity at mucosal surfaces. Among mucosal vaccines, oral mucosal vaccines have the advantages of ease and low cost of vaccine administration. The oral mucosal immune system, however, is generally recognized as poorly immunogenic due to the frequent induction of tolerance against orally-introduced antigens. Consequently, a prerequisite for successful mucosal vaccination is that the orally introduced antigen should be transported across the mucosal surface into the mucosa-associated lymphoid tissue (MALT). In particular, M cells are responsible for antigen uptake into MALT, and the rapid and effective transcytotic activity of M cells makes them an attractive target for mucosal vaccine delivery, although simple transport of the antigen into M cells does not guarantee the induction of specific immune responses. Consequently, development of mucosal vaccine adjuvants based on an understanding of the biology of M cells has attracted much research interest. Here, we review the characteristics of the oral mucosal immune system and delineate strategies to design effective oral mucosal vaccines with an emphasis on mucosal vaccine adjuvants.

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Oral Tolerance Increased the Proportion of CD8+ T Cells in Mouse Intestinal Lamina Propria

Cited by 2 publications

References 21 publications

Nanoparticles from Plant Saponins as Delivery System for Mucosal Influenza Vaccine

Nanoparticles from Plant Saponins as Delivery System for Mucosal Influenza Vaccine

Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination

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