Oral Tizanidine, an α2-Adrenoceptor Agonist, Reduces the Minimum Alveolar Concentration of Sevoflurane in Human Adults

Wajima, Zen’ichiro; Yoshikawa, Takaki; Ogura, Akira; Imanaga, Kazuyuki; Shiga, Toshiya; Inoue, Tetsuo; Ogawa, Ryo

doi:10.1097/00000539-200208000-00028

Cited by 11 publications

(13 citation statements)

References 16 publications

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“…It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. [ 3 7 9 ]…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Wajima et al . [ 9 ] reported that premedication with 4 mg oral tizanidine, 90 min before surgical skin incision significantly shortens the time to loss of consciousness in the study group than in the control group ( P = 0.03) and it successfully reduces the minimum alveolar concentration of sevoflurane by 18% in human adults. In this study, the authors concerned on the sedative effect of tizanidine during anesthesia rather than its postoperative analgesic effect which was our major concern.…”

Section: Discussionmentioning

confidence: 99%

“…The side effects of tizanidine include drowsiness, xerostomia, fatigue, asthenia, anxiety, headache, bradycardia and low arterial blood pressure, gastrointestinal and liver disorders, which are principally dose-dependent. [ 8 ] This drug is absorbed easily by gastrointestinal system and after the oral administration, the peak plasma concentration will occur in one or 2 h. The eliminative half-life of this drug is between 2 and 4 h.[ 9 ]…”

Section: Introductionmentioning

confidence: 99%

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The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy

2016

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Background:Cholecystectomy is considered as the most important and relatively common postoperative pain control often begins in recovery room by using systemic narcotics that may have some side effects. The aim of this study is to evaluate the effect of premedication with oral tizanidine on pain relief after elective laparoscopic cholecystectomy.Materials and Methods:In this double-blinded clinical trial, 70 adults of American Society of Anesthesiologist physiologic state 1 and 2 scheduled for elective laparoscopic cholecystectomy under general anesthesia were studied and randomly divided in two study and control groups. Ninety minutes before the induction of anesthesia, patients received either 4 mg tizanidine (study group) orally in 50cc or the same volume of plain water as a placebo (control group). Then, the vital signs, pain intensity, duration of stay in recovery, and the analgesic consumption were measured and then compared in both groups during 24 h postoperatively.Results:There was no significant difference in patient characteristics, with respect to age, weight, gender, and duration of anesthesia and surgery between the groups (P > 0.05). The pain intensity, need for analgesic drugs (34.57 ± 8.88 mg vs. 101.86 ± 5.08 mg), and the duration of stay in recovery room (67.43 ± 1.59 min vs. 79.57 ± 5.48 min) were significantly lower in tizanidine group than that of the control group.Conclusion:Oral administration of 4 mg tizanidine before laparoscopic cholecystectomy reduces postoperative pain, opioid consumption, and consequence of the duration of stay in recovery room without any complication.

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“…It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. [ 3 7 9 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy

2016

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“…Butorphanol and Tramadol are more effective than Clonidine to inhibit the shivering, as suggested by Bansal et al in a study aimed at comparing the effectiveness of these drugs on postoperative shivering (20). Wajima et al declared that prescribing 4 mg of oral Tizanidine 90 minutes prior to surgery lead to an 18% decline in minimum alveolar concentration (MAC) of Sevoflurane (21). In a study on 60 patients undergoing coronary artery bypass graft (CABG) operation, Manjula et al concluded that intravenous administration of 4mg Clonidine 30 minutes before the operation diminished the amount of drug required to induce anesthesia (14).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oral Tiazinidine Effects on [intraoperative] Hemodynamic Responses During Direct Laryngoscopy Under General Anesthesia

Tabari

Alipour

Esalati

2013

Iran Red Crescent Med J

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BackgroundDirect laryngoscopy and tracheal intubation can result in blood pressure and heart rate increase which in turn may lead to myocardial ischemia, cerebral hemorrhage, and even death in susceptible patients. Tizanidine is α2-receptor agonists that suppresses central sympathetic system.ObjectivesThis study evaluates the effects of oral Tizanidine on hemodynamic responses during operations and aims to determine the appropriate Propofol dosage to maintain anesthesia under BIS monitoring.Materials and MethodsA double-blind clinical trial has been performed on 70 candidates for elective abdominal surgery undergoing general anesthesia in Educational Hospital of Ghaem, Mashhad, Iran. 35 randomly selected patients (the case group) were given 4 mg of oral Tizanidine 90 minutes before the induction of anesthesia whereas the remaining subjects (the control group) were given placebo. Blood pressure and heart rate before and after induction of anesthesia, and after intubation and extubation, existence of postoperative shivering, and the needed Propofol dosage were measured and recorded. Data analysis was done with T-test and Chi-squared test, using SPSS software version 16.ResultsVariations of blood pressure and heart rate after anesthesia induction, intubation and extubation were less in Tizanidine group generally. Postoperative shivering was reported in 28.6% and 11.4% of patients in control and case group respectively. Average propofol needed dose for anesthesia maintenance in case group was 25% less than the needed amount in the control group.ConclusionsUsing oral Tizanidine as a premedication, yielded stability in blood pressure and heart rate during surgery and decreased required Propofol. Considering its short duration of action, Tizanidine use as a premedication is recommended for sedation and stabilization of hemodynamic responses during the operations.

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“…The anesthesiologist was blinded to the study group assignments. Anesthesia was induced in all patients by vital capacity rapid inhalation induction (VCRII) of sevoflurane, as previously described [7,8]. The VCRII method was performed as follows: patients were first preoxygenated with 100% oxygen at a flow rate of 8 L/min for 5 minutes by face mask and a Jackson-Rees circuit.…”

Section: Methodsmentioning

confidence: 99%

Intravenous landiolol, a novel β1-adrenergic blocker, reduces the minimum alveolar concentration of sevoflurane in women

Wajima

Tsuchida

Shiga

et al. 2011

Journal of Clinical Anesthesia

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Oral Tizanidine, an α2-Adrenoceptor Agonist, Reduces the Minimum Alveolar Concentration of Sevoflurane in Human Adults

Abstract: Oral tizanidine (4 mg), an alpha2-adrenoceptor agonist, reduces the minimum alveolar concentration of sevoflurane by 18%.

Cited by 11 publications

References 16 publications

The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy

The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy

Evaluation of Oral Tiazinidine Effects on [intraoperative] Hemodynamic Responses During Direct Laryngoscopy Under General Anesthesia

Intravenous landiolol, a novel β1-adrenergic blocker, reduces the minimum alveolar concentration of sevoflurane in women

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