Inferior alveolar nerve (IAN) transposition is a well-known technique which utilises existing alveolar bone for implant placement in posterior mandible, thus avoiding additional procedures such as bone graft or ridge augmentation. Multiple sclerosis (MS) is a disorder affecting the myelin sheath of the nerve and causes varying degrees of sensory-motor neural dysfunction. A case of a 55-year-old Caucasian female with MS undergoing IAN transposition for management of atrophic mandible is discussed here. At the end of 1 year, there was minimal residual sensory deficit, not affecting function.