Oral tamoxifen citrate treatment is more effective in normogonadotropic patients who have follicle-stimulating hormone levels within the lower half of normal

Kadioglu, Teoman Cem

doi:10.1007/s11255-009-9568-3

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…In line with prior findings, we revealed increased serum levels of testosterone, FSH and LH after 3 months of treatment in our cohort of patients, which clearly emphasizes the use of tamoxifen in iOAT. Furthermore, 2 prior studies pointed out that the elevated FSH and testosterone serum levels were associated with the use of tamoxifen [4,15]. In our study, we confirmed the predictive role of FSH serum levels prior to treatment with tamoxifen regarding the improvement of sperm parameters: improved sperm motility was shown at lower serum levels of FSH before the start of treatment with the ideal cut-off value of 8.8 mIU/mL.…”

Section: Discussionsupporting

confidence: 86%

Efficacy of the Oestrogen Antagonist Tamoxifen on Sperm Parameters in Patients with Idiopathic Oligoathenoteratozoospermia

Paffenholz

Votteler

Nazari³

et al. 2019

Urol Int

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Background: The oestrogen antagonist tamoxifen has been suggested as an empiric treatment option for treating idiopathic oligoathenoteratozoospermia (iOAT). Objectives: To analyse the use of tamoxifen in iOAT. Method: Fifty-seven men receiving tamoxifen for iOAT were recruited from 2016 to 2017 in a retrospective, single-centre setting. Hormone and semen analysis was performed before and after 3 months of treatment. Results: After a 3-month treatment, serum levels of testosterone (3.4 ng/mL [2.7–4.8] vs. 5.3 [3.1–7.1]; p = 0.026), follicle stimulating hormone (FSH; 7.6 [5.9–11.5] vs. 15.9 mIU/mL [8.4–19.9]; p = 0.003) and luteinizing hormone (4.5 [3.3–6.6] vs. 7.6 mIU/mL [4.8–10.7]; p = 0.007) significantly increased. At a cut-off of >8.8 mIU/mL, serum levels of FSH were predictive for an improved sperm motility (OR 0.229 [95% CI 0.068–0.773]; p = 0.018) and serum levels of inhibin B were predictive for an improved total sperm count at a cut-off of <82 ng/L (OR 18.0 [95% CI 1.267–255.744]; p = 0.033). During an 11 month-follow-up, patients receiving tamoxifen showed a clinical pregnancy rate of 42%, leading to a live birth rate of 56% of all pregnant women. Twenty-three per cent of all patients reported non-serious adverse events. Conclusions: Tamoxifen is effective in improving the total sperm count as well as motility and can thus be safely used as empiric medical therapy in iOAT.

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Section: Discussionsupporting

confidence: 86%

Efficacy of the Oestrogen Antagonist Tamoxifen on Sperm Parameters in Patients with Idiopathic Oligoathenoteratozoospermia

Paffenholz

Votteler

Nazari³

et al. 2019

Urol Int

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“…Tamoxifen not only has antagonistic effects on hypothalamic ERs but also has peripheral agonist effects that can decrease bone turnover and increase bone mineral density [109]. Tamoxifen has also been shown to raise T levels and may be effective in the treatment of male infertility [110] but does not seem to affect sexual function in healthy young men [86]. Further research is needed to determine how peripheral estrogenic effects of SERMs relate to male sexual function in the setting of T deficiency.…”

Section: Clinical Implications Of Elevated Estrogensmentioning

confidence: 99%

Estrogens in Men: Clinical Implications for Sexual Function and the Treatment of Testosterone Deficiency

Kacker

Traish

Morgentaler

2012

The Journal of Sexual Medicine

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“…A recent article suggests a better effect of TMX in patients with low FSH levels before starting the therapy [57] suggesting the need for a well-functioning hypothalamic-pituitary-gonadal axis.…”

Section: Treatment For Infertile Men With Idiopathic Oligo-/azoospmentioning

confidence: 99%

Estrogens as Antioxidant Modulators in Human Fertility

Mancini

Raimondo

Persano

et al. 2013

International Journal of Endocrinology

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Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.

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Oral tamoxifen citrate treatment is more effective in normogonadotropic patients who have follicle-stimulating hormone levels within the lower half of normal

Cited by 7 publications

References 15 publications

Efficacy of the Oestrogen Antagonist Tamoxifen on Sperm Parameters in Patients with Idiopathic Oligoathenoteratozoospermia

Efficacy of the Oestrogen Antagonist Tamoxifen on Sperm Parameters in Patients with Idiopathic Oligoathenoteratozoospermia

Estrogens in Men: Clinical Implications for Sexual Function and the Treatment of Testosterone Deficiency

Estrogens as Antioxidant Modulators in Human Fertility

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