Oral symptoms including dental erosion in gastroesophageal reflux disease are associated with decreased salivary flow volume and swallowing function

Yoshikawa, Hiroaki; Furuta, K.; Ueno, Masayoshi; Egawa, Masayoshi; Yoshino, Aya; Kondo, Seiji; Nariai, Yoshiki; Ishibashi, Hiroyuki; Kinoshita, Yoshikazu; Sekine, Joji

doi:10.1007/s00535-011-0515-6

Cited by 64 publications

(95 citation statements)

References 31 publications

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“…Maintaining a sufficient amount of saliva is effective for preventing dental caries and improvement of oral symptoms in gastroesophageal reflux disease (GERD) [37]. However, the present study showed no significant difference in the rate of change in the amount of saliva or in the rate of change in salivary pH before and after the use of the active agent between patients who responded and those who did not respond to the agent.…”

Section: Discussioncontrasting

confidence: 54%

Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study

Nakato¹,

Manabe²,

Shimizu

et al. 2017

Digestion

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Background/Aims: The standard of care for older patients with oropharyngeal dysphagia (OD) is poor. Stimulation of transient receptor potential vanilloid 1 might become a pharmacological strategy for these patients. This study aimed to compare the therapeutic effect of film food containing 0.75 µg of capsaicin in these patients. Methods: In a crossover, randomized trial, 49 patients with OD were provided capsaicin or identical placebo at least 7 days apart. Patients' reported symptoms during repeated swallowing, the volume, pH and substance P (SP) concentrations in saliva, and cervical esophageal wall motion evaluated by ultrasonographic tissue Doppler imaging were obtained before and after capsaicin or placebo administration. Results: Significantly more patients with OD who took capsaicin experienced improvement in symptoms than those who took placebo. Salivary SP levels were significantly increased after capsaicin administration compared with placebo in the effective group. The duration of cervical esophageal wall opening was significantly shorter in capsaicin administration in the effective group. Furthermore, a significant negative correlation was found between the duration of cervical esophageal wall opening and salivary SP levels. Conclusion: Elevated salivary SP concentrations stimulated by capsaicin greatly improve the safety and efficacy of swallowing, and shorten the swallow response in older patients with OD.

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Section: Discussioncontrasting

confidence: 54%

Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study

Nakato¹,

Manabe²,

Shimizu

et al. 2017

Digestion

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“…To resolve this issue, the influence of therapy for periodontitis on GERD prevalence should be investigated in collaboration with dentists in a future study. Several investigators have reported that dental erosion is correlated with the prevalence of GERD (24)(25)(26)(27). Therefore, the relationship with GERD associated dental erosion is considered to be different than that between GERD and periodontitis, though those may have some effect on each other.…”

Section: Discussionmentioning

confidence: 99%

“…In addi-tion, periodontitis may induce or worsen GERD, since saliva secretion, which is influenced by oral hygiene including the periodontal status, has been demonstrated to be associated with GERD (21)(22)(23). Reflux of the gastric acidic contents into the oral cavity may also affect the local bacterial flora and the status of periodontitis, since several investigators have reported a close correlation between dental erosion and gastroesophageal acid reflux (24)(25)(26)(27). However, the relationship between periodontitis and GERD has not been determined.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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Objective Metabolic syndrome and dental erosion have been demonstrated to correlate with gastroesophageal acid reflux disease (GERD), while periodontitis has been reported to have a positive relationship with metabolic syndrome. However, no correlation between periodontitis and GERD has yet been reported. We therefore investigated the relationship between periodontitis and GERD. Methods The subjects consisted of 280 individuals who visited the Health Center for a detailed medical checkup examination. Each underwent upper endoscopy and periodontitis examinations, with the latter performed by measuring the concentrations of lactate dehydrogenase and hemoglobin in saliva. The subjects were divided into those with positive and negative periodontitis findings, and the prevalence rates of endoscopically proven reflux esophagitis, dyslipidemia, hypertension, and hyperglycemia were compared. Results The number of subjects positive for periodontitis was 93, while 187 had negative findings. The prevalence of reflux esophagitis was not different between the positive and negative groups (8.6% vs. 8.0%). In addition, a multiple logistic regression analysis did not identify a positive relationship between the presence of periodontitis and reflux esophagitis. On the other hand, dyslipidemia and hypertension were more frequently observed in the subjects that were positive for periodontitis. Conclusion We did not find an association between periodontitis and reflux esophagitis in the present study. On the other hand, the presence of periodontitis was found to correlate with hypertension and dyslipidemia.

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“…Oral problems arising as a direct result of GERD include tooth erosion and halitosis [5,[25][26][27]. Tooth erosion is thought to result from the acidity of the gastric contents that reach the mouth during repeated GERD episodes, especially if they are inadequately buffered by saliva [28,29].…”

Section: Introduction Backgroundmentioning

confidence: 99%

Effect on Acid Reflux Symptoms Occurring during Sleep of an Oral Adhering Disc Containing only Food Ingredients

Burgess¹,

Kärcher²

2017

J Gastrointest Dig Syst

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The aim of this double-blinded, randomized, controlled study was to determine if OraCoat XyliMelts, an over the counter, dissolvable, adhering disc used to reduce excessive day time or night time dry mouth by increasing salivation, would also reduce reflux and heartburn symptoms occurring during sleep among subjects suffering from both GERD and xerostomia. Subjects submitted 14 days of baseline data by answering questions and were then randomized into one of two groups: one receiving a dry mouth gel (control) and a second receiving a disc (product of interest). Neither the identities of the two products nor the manufacturers of the products was revealed to subjects. Answers to the same set of questions were then collected for an additional 14 days as the supplied products were used. The accumulated data were evaluated for pre-post treatment changes within and between groups. Variables included reported heartburn, reflux, reflux taste, hoarseness, dry mouth, and antacid use. The results showed a significant decrease in the severity of the above symptoms of GERD with both disc and gel use, although improvement was greatest for those using the discs. Comparison between the gel and disc groups for most symptoms did not reveal significant differences. For heartburn, subjects using the discs perceived significantly less pain than subjects using the gel. We conclude that the use of certain products intended to reduce dry mouth during sleep, including OraCoat XyliMelts, may be an effective adjunctive remedy for reducing reflux and heartburn symptoms in patients with GERD and xerostomia.

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Oral symptoms including dental erosion in gastroesophageal reflux disease are associated with decreased salivary flow volume and swallowing function

Abstract: Oral symptoms in GERD are likely to be associated with impaired salivary flow volume or swallowing function. Treatment for the oral dryness induced by reduced salivary flow volume and rehabilitation for swallowing function could be indicated in patients with GERD.

Cited by 64 publications

References 31 publications

Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study

Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study

A Study on the Relationship between Reflux Esophagitis and Periodontitis

Effect on Acid Reflux Symptoms Occurring during Sleep of an Oral Adhering Disc Containing only Food Ingredients

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