Oral symptoms and lesions in SARS‐CoV‐2‐positive patient

Glavina, Ana; Biočina‐Lukenda, Dolores; Stipetić, Marinka Mravak; Markeljević, Jasenka

doi:10.1111/odi.13596

Cited by 27 publications

(37 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Covid‐19 is a viral infection caused by SARS‐CoV‐2 that has manifestations in multiple organs of the human body 12–14 . Patients infected with SARS‐CoV‐2 present a myriad of clinical signs and symptoms with variable severity 15 .…”

Section: Oral Disease Manifestation In Sars‐cov‐2 Patientsmentioning

confidence: 99%

“…Patients infected with SARS‐CoV‐2 present a myriad of clinical signs and symptoms with variable severity 15 . In the oral cavity, the main manifestations are related to tongue depapillation, 16,17 Candida ‐associated lesions, 17 xerostomia, 18 aphthous like‐lesions, 13,17 recurrent herpesvirus infection, 12,13,19 ulcers, 14,19–22 necrotising gingivitis, 23 erythema multiforme‐like lesions 24 and salivary gland infections 25 . It has been reported that these oral manifestations, in general, appear concomitant with the loss of smell and/or taste a few days later (up to 14 days), and progress more rapidly and severely among older patients 13 .…”

Section: Oral Disease Manifestation In Sars‐cov‐2 Patientsmentioning

confidence: 99%

“…Covid‐19 patients present with a broad variety of signs and symptoms, including a variety of oral lesions 12–14,16,17,19–21,26,44–46 . In Covid‐19 patients, oral lesions may resemble dermatologic lesions and the prevalence of oral and dermatologic lesions are similar (about 2%–20%) 47,48 .…”

Section: Oral Disease Manifestation In Sars‐cov‐2 Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Covid‐19 and oral diseases: Crosstalk, synergy or association?

Brandini

Takamiya

Thakkar

et al. 2021

Reviews in Medical Virology

View full text Add to dashboard Cite

Summary The coronavirus disease 2019 (Covid‐19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that clinically affects multiple organs of the human body. Cells in the oral cavity express viral entry receptor angiotensin‐converting enzyme 2 that allows viral replication and may cause tissue inflammation and destruction. Recent studies have reported that Covid‐19 patients present oral manifestations with multiple clinical aspects. In this review, we aim to summarise main signs and symptoms of Covid‐19 in the oral cavity, its possible association with oral diseases, and the plausible underlying mechanisms of hyperinflammation reflecting crosstalk between Covid‐19 and oral diseases. Ulcers, blisters, necrotising gingivitis, opportunistic coinfections, salivary gland alterations, white and erythematous plaques and gustatory dysfunction were the most reported clinical oral manifestations in patients with Covid‐19. In general, the lesions appear concomitant with the loss of smell and taste. Multiple reports show evidences of necrotic/ulcerative gingiva, oral blisters and hypergrowth of opportunistic oral pathogens. SARS‐CoV‐2 exhibits tropism for endothelial cells and Covid‐19‐mediated endotheliitis can not only promote inflammation in oral tissues but can also facilitate virus spread. In addition, elevated levels of proinflammatory mediators in patients with Covid‐19 and oral infectious disease can impair tissue homeostasis and cause delayed disease resolution. This suggests potential crosstalk of immune‐mediated pathways underlying pathogenesis. Interestingly, few reports suggest recurrent herpetic lesions and higher bacterial growth in Covid‐19 subjects, indicating SARS‐CoV‐2 and oral virus/bacteria interaction. Larger cohort studies comparing SARS‐CoV‐2 negative and positive subjects will reveal oral manifestation of the virus on oral health and its role in exacerbating oral infection.

show abstract

Section: Oral Disease Manifestation In Sars‐cov‐2 Patientsmentioning

confidence: 99%

Section: Oral Disease Manifestation In Sars‐cov‐2 Patientsmentioning

confidence: 99%

Section: Oral Disease Manifestation In Sars‐cov‐2 Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Covid‐19 and oral diseases: Crosstalk, synergy or association?

Brandini

Takamiya

Thakkar

et al. 2021

Reviews in Medical Virology

View full text Add to dashboard Cite

show abstract

“…The clinical symptoms of HCoV often include one or more of fever, cough, sneeze, respiratory distress, wheeze, pharyngitis, nasal discharge, nasal congestion, sputum, rhinorrhea, chills, muscle aches, headache, and gastrointestinal tract symptoms [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] . COVID-19 can cause additional issues such as loss of taste/smell, nausea and vomiting, anorexia, liver dysfunction, hyperglycaemia, septic shock and ventilator-associated pneumonia [85] , [86] , [87] , [88] , [89] , [90] as well as conjunctivitis [91] , [92] . The emergence of new versions of coronaviruses, threatening the human and animal health, has highlighted the importance of the discovery of effective antiviral agents, as will be discussed in the next section.…”

Section: Animal and Human Infectious Coronavirusesmentioning

confidence: 99%

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Seifi

Kamali

2021

Medicine in Drug Discovery

View full text Add to dashboard Cite

Coronavirus disease-2019 has been one of the most challenging global epidemics of modern times with a large number of casualties combined with economic hardships across the world. Considering that there is still no definitive cure for the recent viral crisis, this article provides a review of nanomaterials with antiviral activity, with an emphasis on graphene and its derivatives, including graphene oxide, reduced graphene oxide and graphene quantum dots. The possible interactions between surfaces of such nanostructured materials with coronaviruses are discussed. The antiviral mechanisms of graphene materials can be related to events such as the inactivation of virus and/or the host cell receptor, electrostatic trapping and physico-chemical destruction of viral species. These effects can be enhanced by functionalization and/or decoration of carbons with species that enhances graphene-virus interactions. The low-cost and large-scale preparation of graphene materials with enhanced antiviral performances is an interesting research-direction to be explored.

show abstract

“…Glavina et al [62] presented the oral manifestations related to COVID-19 in a 40-year-old female with no comorbidities and a history of frequent eruptions of recurrent herpes labialis. Dysgeusia was described as the initial symptom, followed by pain and burning sensation in the oral cavity 7 days after the patient was confirmed positive for SARS-CoV-2.…”

Section: Oral Lesions Related To Covid-19mentioning

confidence: 99%

COVID-19 and Its Repercussions on Oral Health: A Review

et al. 2021

View full text Add to dashboard Cite

In 2019, a new type of coronavirus, SARS-CoV-2, the causing agent of COVID-19, was first detected in Wuhan, China. On 11 March 2020, the World Health Organization declared a pandemic. The manifestations of COVID-19 are mostly age-dependent and potentially more severe in cases with involved co-morbidities. The gravity of the symptoms depends on the clinical stage of the infection. The most common symptoms include runny nose and nasal congestion, anosmia, dysgeusia or hypogeusia, diarrhea, nausea/vomiting, respiratory distress, fatigue, ocular symptoms, diarrhea, vomiting, and abdominal pain. These systemic conditions are often accompanied by skin and mucosal lesions. Oral lesions reported in patients with COVID-19 include: herpex simplex, candidiasis, geographic tongue, aphthous-like ulcers, hemorrhagic ulcerations, necrotic ulcerations, white hairy tongue, reddish macules, erythematous surfaces, petechiae, and pustular enanthema. It is still unclear if these manifestations are a direct result of the viral infection, a consequence of systemic deterioration, or adverse reactions to treatments. Poor oral hygiene in hospitalized or quarantined COVID-19 patients should also be considered as an aggravating condition. This narrative review is focused on presenting the most relevant data from the literature regarding oral manifestations related to SARS-CoV-2, as well as the challenges faced by the dental system during this pandemic. A routine intraoral examination is recommended in COVID-19 patients, either suspected or confirmed, as, in certain cases, oral manifestations represent a sign of severe infection or even of a life-threatening condition. It is our belief that extensive knowledge of all possible manifestations, including oral lesions, in cases of COVID-19 is of great importance in the present uncertain context, including new, currently emerging viral variants with unknown future impact.

show abstract

Oral symptoms and lesions in SARS‐CoV‐2‐positive patient

Cited by 27 publications

References 9 publications

Covid‐19 and oral diseases: Crosstalk, synergy or association?

Covid‐19 and oral diseases: Crosstalk, synergy or association?

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

COVID-19 and Its Repercussions on Oral Health: A Review

Contact Info

Product

Resources

About