Oral supplementation of branched‐chain amino acid improves nutritional status in elderly patients on chronic haemodialysis

Hiroshige, Kinya; Sonta, Toshiyo; Suda, Takafumi; Kanegae, Kaori; Ohtani, Akira

doi:10.1093/ndt/16.9.1856

Cited by 143 publications

(98 citation statements)

References 20 publications

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“…Clinical data indicate that BCAA supplementation reduces the incidence of anorexia in cancer and malnourished patients and in patients with liver cirrhosis (Cangiano et al, 1996;Hiroshige et al, 2001;Marchesini et al, 2003;Laviano et al, 2005Laviano et al, , 2006Biolo et al, 2006). In a placebocontrolled multi-center trial in cirrhotic patients (n ¼ 174), 1 year supplementation with BCAA resulted in a decreased prevalence of anorexia from 52 to 25%, whereas anorexia prevalence remained unchanged in the control group (Marchesini et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

et al. 2009

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Cancer cachexia is characterised by metabolic alterations leading to loss of adipose tissue and lean body mass and directly compromises physical performance and the quality of life of cancer patients. In a murine cancer cachectic model, the effects of dietary supplementation with a specific combination of high protein, leucine and fish oil on weight loss, muscle function and physical activity were investigated. Male CD2F1 mice, 6 -7 weeks old, were divided into body weight-matched groups: (1) control, (2) tumourbearing, and (3) tumour-bearing receiving experimental diets. Tumours were induced by s.c. inoculation with murine colon adenocarcinoma (C26) cells. Food intake, body mass, tumour size and 24 h-activity were monitored. Then, 20 days after tumour/ vehicle inoculation, the animals were killed and muscle function was tested ex vivo. Tumour-bearing mice showed reduced carcass, muscle and fat mass compared with controls. EDL muscle performance and total daily activity were impaired in the tumour-bearing mice. Addition of single nutrients resulted in no or modest effects. However, supplementation of the diet with the all-in combination of high protein, leucine and fish oil significantly reduced loss of carcass, muscle and fat mass (loss in mass 45, 52 and 65% of TB-con, respectively (Po0.02)) and improved muscle performance (loss of max force reduced to 55 -64% of TB-con (Po0.05)). Moreover, total daily activity normalised after intervention with the specific nutritional combination (50% of the reduction in activity of TB-con (Po0.05)). In conclusion, a nutritional combination of high protein, leucine and fish oil reduced cachectic symptoms and improved functional performance in cancer cachectic mice. Comparison of the nutritional combination with its individual modules revealed additive effects of the single components provided.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

et al. 2009

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“…In addition, leucine has known antiproteolytic properties (40,58). Indeed, in a small doubleblinded study, the nutritional status of malnourished hemodialysis patients improved when given oral BCAA supplements (26).…”

Section: E878mentioning

confidence: 99%

Leucine-stimulated mTOR signaling is partly attenuated in skeletal muscle of chronically uremic rats

Chen

Sood

McIntire

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

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“…13 Similarly, a branched chain amino acid supplementations have been able to increase serum albumin and to ameliorate nutritional status in hemodialysis patients. 14 A special mixture including all of the essential amino acids (EAs) plus two nonessential amino acids (NEAs) (tyrosine and cystine) in a complex ratio that was designed to match metabolic requirements under high demand has been recently investigated in several studies. This amino acid formulation has been reported to exert beneficial effect in elderly people, 15,16 in elderly patients affected by chronic heart failure, 17 and in patients with type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

A Novel Amino Acids Oral Supplementation in Hemodialysis Patients: a Pilot Study

et al. 2011

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Background: Protein malnutrition and lowering serum albumin is frequent in hemodialysis patients. A special amino acid formulation has recently been used with favorable effects in elderly people but no data exist in renal patients. Aim: To assess the effects of this novel amino acid formulation in stable hemodialysis patients with reduced albumin levels. Methods: Thirty stable hemodialysis patients with serum albumin levels <3.5 g/dL, normalized protein nitrogen appearance (nPNA) <1.1 g/kg/d, and body mass index (BMI) >20 kg/m 2 were selected: 15 patients were randomized to oral amino acid supplementation (4 g thrice a day) for 3 months and 15 patients comparable for age, gender, and dialysis durations formed the control group. Biochemistry and bioimpedentiometry parameters were measured at baseline and at the end of treatment. Results: No difference was observed between study group and control group at baseline. At the end of the study period, no change occurred in the studied parameters in the control group, whereas increase in serum albumin (3.1 ± 0.3 vs. 3.6 ± 0.2 g/dL, p < 0.001) and in total proteins (5.7 ± 0.4 vs. 6.4 ±0.7 g/dL, p < 0.001) occurred in the study group. Hemoglobin rose from 10.7 ± 0.9 to 11.7 ± 0.8 g/dL (p < 0.05) at the same erythropoiesis-stimulating agent (ESA) dosage. C-Reactive protein (CRP) levels decreased in the study group (8.7 ± 7.3 vs. 3.8 ± 3.1 mg/L, p < 0.01). Increase of body weight and of equilibrated protein catabolic rate (ePCR) was observed in the study group. Conclusions: Oral amino acids supplementation was able to improve albumin and total protein in hypoalbuminemia hemodialysis patients. This effect was associated with reduction of CRP levels that is with lowering of pro-inflammatory status and anemia improvement.

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Oral supplementation of branched‐chain amino acid improves nutritional status in elderly patients on chronic haemodialysis

Abstract: Normalization of low plasma levels of BCAA by oral supplementation can reduce anorexia and significantly improve overall nutritional status in elderly malnourished HD patients.

Cited by 143 publications

References 20 publications

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

Leucine-stimulated mTOR signaling is partly attenuated in skeletal muscle of chronically uremic rats

A Novel Amino Acids Oral Supplementation in Hemodialysis Patients: a Pilot Study

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