Oral Supplementation Effect of Iron and its Complex Form With Quercetin on Oxidant Status and on Redistribution of Essential Metals in Organs of Streptozotocin Diabetic Rats

Abstract

Background and aims: Quercetin, is a polyphenolic antioxidant compound. It is able to form complex with metal ions such as iron and exerts a broad range of biological activities like improving metabolic disorders. This research aims at investigating the effect of oral supplementation of iron (2.5mg Fe/Kg/day) and its complex form (molar ratio 1:5; 2.5mg/25mg/Kg/day) with quercetin (25mg/Kg/day) on lipid metabolism, oxidant status and trace elements contents in organs of Wistar diabetic rats (45 mg/kg/rat.ip of streptozotocin) during eight weeks of experimentation. Material and method: To achieve this, liver and adipose tissue enzymes activities, NO•, O2−•, TBARs, carbonyl protein levels in plasma were analysed. Metals (Cu, Fe, Mg, Zn) analysis of organs were determined by inductively coupled plasma atomic emission spectroscopy. Results: Iron supplemented alone induced a noticeable disorder in lipid, lipoprotein, lipases and oxidant status. Yet, it caused an imbalance in the redistribution of metals in the organs of diabetic and non diabetic rats. Iron-quercetin complex was shown as less harmful and more beneficial than iron supplemented alone. Conclusions: This complex could reverse oxidative stress and iron deficiency mostly caused by the diabetic disease but at the same time it induces an imbalance in redistribution of other essential metals.

Quercetin Beneficial Role in the Homeostatic Variation of Certain Trace Elements in Dyslipidemic Mice

“…Furthermore, we observed an increase in Ag, Ba, Cr, Fe, Ni, and Zn in the blood, Li and Ni in the liver, Fe, Li, Mg, Ni, and Zn in the spleen, and Fe, Li, Mg, and Zn in the heart of HFD mice when supplemented with quercetin. e imbalance between the concentrations of different trace elements, which were observed in different organs, could be explained by a selective influence of the hyperglycemic-hyperinsulinemic state on the ability of different organs to extract these metals [10], being demonstrated that flavonoids have an insulin-mimic property [45].…”

“…Dyslipidemia is one of the factors that can be modified to prevent the development of cardiovascular diseases, atherosclerosis, stroke, and type 2 diabetes [1,[3][4][5][6][7][8]. e 3, 3′, 4′, 5, 7-pentahydroxyflavone, known as quercetin, is a flavonoid that could be found widely in a large variety of fruits and vegetables [9][10][11].…”

“…ese are basically focused on diabetes, in humans [15,16] and animals [17], obesity, in humans [18][19][20] and animals [21], and those who enclose dyslipidemia, delimited to only one or not many trace elements such as copper, magnesium, and selenium [2,[22][23][24]. Regarding the interrelationship of quercetin, trace elements, and metabolic syndrome, studies are scarce and also quite limited to diabetes [10] and obesity [21]. Consequently, the aim of this study (part of a larger one on this topic) was to find whether dietary quercetin supplementation plays a role in the homeostasis of trace elements in mice with induced dyslipidemia.…”

Quercetin and Egg Metallome

“…Furthermore, quercetin’s complex with Zn interacts with DNA and exerts antioxidative and anti-tumour activities [ 17 ]. As it has been shown in diabetic rats, iron-quercetin complex could reverse oxidative stress and iron deficiency mostly caused by the diabetes but concurrently it induces an imbalance in redistribution of other essential metals [ 18 ].…”