Oral submucous fibrosis transforming into squamous cell carcinoma: a prospective study over 31 years in mainland China

Jian, Xie; Jian, Yu; Wu, Xiaoxia; Guo, Feng; Hu, Yanjia; Gao, Xing; Jiang, Canhua; Li, Ning; Wu, Yongming; Liu, Deyu

doi:10.1007/s00784-020-03541-9

Cited by 11 publications

(11 citation statements)

References 18 publications

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“…Oral submucous fibrosis (OSF) is characterized by fibrosis of the oral mucosa. As a pre-cancerous lesion of oral squamous cell carcinoma (OSCC), OSF has a malignancy rate of 1.5–15% [ 1 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis

Liu

Xie

2022

BMC Oral Health

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Background Key lncRNAs associated with the malignant progression of oral submucous fibrosis (OSF) to oral squamous cell carcinoma (OSCC) were identified. Methods Key lncRNAs with sequential changes from normal oral mucosa (NOM) to OSF to OSCC were identified based on the GEO database. Kaplan–Meier analysis was used to screen lncRNAs related to OSCC prognosis. Cox regression analysis was used to validate the independent prognostic value. qPCR was used to confirm the expression of the candidate lncRNAs. Gene set enrichment analysis (GSEA), nucleocytoplasmic separation assay, fluorescence in situ hybridization, RNA knockdown, western blot, and cell viability assay were performed to investigate the biological functions of the candidate lncRNA. A nomogram was constructed to quantitatively predict OSCC prognosis based on TCGA. Results Bioinformatics methods indicated that LINC02147 was sequentially downregulated from NOM to OSF to OSCC, as confirmed by clinical tissues and cells. Meanwhile, low LINC02147 expression, as an independent prognostic factor, predicted a poor prognosis for OSCC. GSEA and in vitro studies suggested that low LINC02147 expression promoted OSF malignant progression by promoting cell proliferation and differentiation. A LINC02147 signature-based nomogram successfully quantified each indicator’s contribution to the overall survival of OSCC. Conclusions Low LINC02147 expression promoted OSF malignant progression and predicted poor OSCC prognosis.

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Section: Introductionmentioning

confidence: 99%

Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis

Liu

Xie

2022

BMC Oral Health

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“…Notably, cancer screening and early detection of cancer are not in the keyword list of Mainland but in that of Taiwan. Based on the representative results of investigations, 1 , 2 , 3 , 4 , 5 , 6 the MTR of OSF in Taiwan is higher than in Mainland, while the MTR of OLK in Taiwan is lower than in Mainland ( Fig. 2 D).…”

Section: Resultsmentioning

confidence: 94%

“… 1 , 2 , 3 , 4 The MTR of the same subtype or the different subtypes of the OPMDs may vary due to distinct ethnic, genetic, geographic, and lifestyle factors. 1 , 2 , 3 , 4 , 5 , 6 Thus, there is a need for comprehensive knowledge and strategy to prevent malignant transformation of OPMDs, especially oral cancer screening.…”

Section: Introductionmentioning

confidence: 99%

Oral potentially malignant disorder research in Taiwan and mainland China: A scientometric analysis

Liu

Yang

Zhang

et al. 2022

Journal of Dental Sciences

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“…There are different opinions on the mechanism of malignant transformation of OSF: direct stimulation of areca nut extracts such as arecoline and copper ions, stimulation of cytokines produced by immune cells and fibroblasts in the lower lamina propria of basal cells, and hypoxia caused by morphological changes. 20,21 In the past, the research on epithelial cells mainly focused on how they indirectly affect lamina propria fibroblast activation when stimulated by arecoline or other chemicals. However, there are few studies on abnormal changes or even malignant transformation in epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis

Wang

et al. 2022

J Oral Pathology Medicine

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Background: Previous studies on oral submucous fibrosis (OSF) mostly focused on the activation of fibroblasts and collagen metabolism, while little involved in the epithelium. As we have reported the role of differentiated embryo-chondrocyte expressed gene 1 (DEC1) in oral cancer and other precancerous lesions, this research aimed to explore its role in the OSF epithelium.Methods: Expression of DEC1 and other proteins were investigated in tissue array constructed with 33 OSF and 14 normal oral mucosa (NOM) tissues. Human oral keratinocytes treated with arecoline and/or hypoxia were used to simulate OSF epithelium and detected for morphological and protein alterations. Inhibition of DEC1 was used to explore its mediating role. Finally, animal models of OSF constructed by locally arecoline injecting in buccal mucosa were used to verify our findings.Results: DEC1 overexpression could be detected in the epithelium of OSF compared with that in NOM followed by phosphorylated FAK and Akt, and DEC1 showed a significant positive correlation with them. Cytology experiment revealed that OSF-like treatment could upregulate DEC1 expression followed by phosphorylated FAK, Akt, but inhibit E-cadherin, while knockdown of DEC1 could suppress the effects. In addition, OSF mice revealed higher expression of DEC1 in the epithelium of buccal mucosa, along with synchronized alterations of phosphorylated FAK and Akt. Conclusion: In the epithelium of OSF, overexpression of DEC1 induced activation of FAK/Akt signal axis, caused mesenchymal transition in epithelial cells, and may promote malignant transformation of OSF. Targeting DEC1 in OSF could be promising a new target for the diagnosis and treatment of this process. K E Y W O R D S arecoline, differentiated embryo-chondrocyte expressed gene 1, focal adhesion kinase, malignant, oral submucous fibrosis 1 | INTRODUCTION Oral submucous fibrosis (OSF) is a chronic mucosal disease that mainly occurs in the buccal and gingival areas of the oral mucosa, and has attracted attention due to causing progressive restriction of Xin Hu and Weiming Wang contributed equally to this study and should be identified as cofirst authors.

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Oral submucous fibrosis transforming into squamous cell carcinoma: a prospective study over 31 years in mainland China

Cited by 11 publications

References 18 publications

Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis

Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis

Oral potentially malignant disorder research in Taiwan and mainland China: A scientometric analysis

Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis

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