Oral submucous fibrosis as a precancerous condition

Abstract

Pindborg JJ, Murti PR, Bhonsle RB, Gupta PC, Daftary DK, Mehta FS: Oral submucous fibrosis as a precancerous condition. Scand J Dent Res 1984; 92: 224-9.Abstract -An evaluation of the malignant potential of submucous fibrosis, based on observations of 89 patients with the disease in Ernakulam District, Kerala, India was done. Out of the 89 patients, 12 were referred patients and 77 were diagnosed in population based studies. At the time of first examination oral cancer was found to be coexistent in nine (10%) cases. For 66 patients follow-up observations ranging from 4 to 15 yr (median 8 yr) were available. During this period malignant transformation was observed in three patients (4.5%). Considering malignant transformation and coexistence together, oral cancer was observed in 13% of the present material. Leukoplakia was found in 26% of the patients with submucous fibrosis. Out of 42 submucous fibrosis patients biopsied, 12% showed squamous cell carcinoma, 26% epithelial dysplasia, and 76% atrophic epithelium. These findings reinforced the hypothesis that submucous fibrosis is a precancerous condition.

Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

“…Incidence of malignant transformation of OSMF was found to be 4.23 % in the present study which is significantly higher than few studies carried out in the past, but is in conformity with the studies of Pindborg et al [19] in 1984, whereas less than the incidence found by Murti et al [14] in 1985. Both these studies were carried out in the Indian subcontinent, where betel nut chewing with or without tobacco is commonly seen in the society.…”

“…OSMF is also found to be associated with other premalignant lesions [14,19] like leukoplakia and erythroplakia and in the present study the incidence of the same was found to be 11 %. Normally in the OSMF, the oral mucous membrane is found to be severely atrophic and development of such lesions like leukoplakia and erythroplakia associated with acanthosis and proliferation of epithelial lining warrants serious thought and early intervention, as it could be a transition from fibrosis to a frank squamous cell carcinoma.…”

“…It has been suggested that ingestion of chillies, genetic susceptibility, nutritional deficiencies, altered salivary constituents, autoimmunity and collagen disorders may be involved in the pathogenesis of this condition [7]. The condition is well recognized for its significant malignant potential, the incidence of which varies from one region to another, as shown by a number of studies [9][10][11][12][13][14]. Pindborg [13] in 1980, from a series of epidemiological surveys conducted in India and South Africa found malignant change in 3 to 6 % of patients having OSMF.…”

Submucous fibrosis secondary to chewing of quids: Another cause of unanticipated difficult intubation

“…It is a precancerous condition and about one third of these patients develop oral cancer. [1][2][3] We describe a patient with SMF who had an associated carcinoma of the hypopharynx, resulting in an unexpected difficult intubation.…”

Systemic Antioxidants in Management of Oral Submucous Fibrosis: A Systematic Review of Randomised Control Trials and Meta–analysis.

“…OSMF is a potentially malignant disorder with a malignant transformation rate of 2.3 to 7.6%. [2][3] The most common debilitating symptoms of OSMF are burning sensation in the mucosa and inability to open mouth which also has psychological and social implications for patients.…”