Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis

Expression of Bcl-2 and MIB-1 Markers in Oral Squamous Cell Carcinoma (OSCC)- A Comparative Study

“…The expression of anti-apoptotic marker, Bcl-2, showed a statistically significant decrease in well to moderate to poorly differentiated OSCCs, which was in accordance with the studies done by Loro et al, [11] and Schoelch et al, [12], where dysregulation of Bcl-2 and loss of its expression were noted with increasing grades of carcinoma. The downregulation of Bcl-2…”

TUNEL – an efficient prognosis predictor of salivary malignancies

“…In this regard, it is interesting to note that previous studies found the level of positive TUNEL staining to be relatively high not only in salivary glands malignancies but also in oral cancer (Loro et al, 1999;Nagler et al, 1999Nagler et al, ,2003. Our results are also supported by multiple recent studies of various nonsalivary malignancies which demonstrated that high scores of Ki67 and p53 staining predict a higher tumourogenic grade, a higher rate of metastasis spread and a poorer prognosis, whereas low scores of Ki67 and p53 are associated with prognostically better histopathologic features (Saleh et al, 2000;Ben-Izhak et al, 2001Jalava et al, 2006).…”

Diabetes enhances cell proliferation but not Bax/Bcl-2-mediated apoptosis during oral oncogenesis

“…A previous study of human OSCC found a decreased Bcl-2/Bax ratio due to increased Bax expression resulting in increased apoptosis in comparison to normal epithelium 14 . Another study proposed that the ratio of Bcl-2/Bax expression seems to be the best variable in predicting disease-specific survival in tongue SCC 27 .…”