Oral squamous cell carcinoma in capuchin monkeys (<i>Cebus apella</i>). Report of two cases

Grana, Daniel; Mareso, Eduardo; Gómez, Elena

doi:10.1111/j.1600-0684.1992.tb00611.x

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…20 Squamous cell carcinoma of the oral cavity has been identified in other NHP species, including several species of macaque, squirrel monkey, baboon, capuchin monkey (Cebus apella), common marmoset (Callithrix jacchus), and a spider monkey (Ateles spp.). 4,18,19,43,45 This is the first report of this tumor in Aotus spp. The pathogenesis is not well defined in NHP, and genetic markers or predisposing conditions are an area in need of research.…”

Section: Discussionmentioning

confidence: 84%

Gastrointestinal tract pathology of the owl monkey (Aotus spp.)

Hensel,

Rodrigues-Hoffmann,

Dray

et al. 2023

Vet Pathol

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Owl monkeys are small nocturnal new world primates in the genus Aotus that are most used in biomedical research for malaria. Cardiomyopathy and nephropathy are well-described common diseases contributing to their morbidity and mortality; less is known about lesions affecting the gastrointestinal tract. Records from a 14-year period (2008-2022) at the Keeling Center for Comparative Medicine and Research were queried to identify instances of spontaneous gastrointestinal disease that directly contributed to the cause of death from the 235 adult owl monkeys submitted for necropsy. Of the 235, 10.6% (25/235) had gastrointestinal disease listed as a significant factor that contributed to morbidity and mortality. Diagnoses included candidiasis (3/25), gastric bloat (4/25), and intestinal incarceration and ischemia secondary (11/25), which included intussusception (4/25), mesenteric rent (3/25), strangulating lipoma (2/25), intestinal torsion (1/25), and an inguinal hernia (1/25). Intestinal adenocarcinomas affecting the jejunum (4/25) were the most common neoplasia diagnosis. Oral squamous cell carcinoma (1/25) and intestinal lymphoma (2/25) were also diagnosed. This report provides evidence of spontaneous lesions in the species that contribute to morbidity and mortality.

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Section: Discussionmentioning

confidence: 84%

Gastrointestinal tract pathology of the owl monkey (Aotus spp.)

Hensel,

Rodrigues-Hoffmann,

Dray

et al. 2023

Vet Pathol

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“…baboons ( Papio spp. ), 3–5 capuchin monkeys ( Cebus apella ), 6 dusky leaf monkeys ( Trachypithecus obscurus ), 5 Francois langurs ( Trachypithecus Francoisi ), 7 macaques ( Macaca spp. ), 8–17 marmosets ( Callithrix spp.…”

Section: Introductionmentioning

confidence: 99%

Oral cavity squamous cell carcinomas in zoo‐managed Goeldi's monkeys (Callimico goeldii)

Rich,

Payne,

Killick

et al. 2024

J of Medical Primatology

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BackgroundOral cavity squamous cell carcinomas (OCSCCs) are relatively common in multiple non‐human primate species but are poorly documented in Goeldi's monkeys.MethodsFour Goeldi's monkeys with OCSCC, from three zoological collections, underwent necropsy with cytology, histopathology, immunohistochemistry, and pan‐herpesvirus PCR analysis.ResultsAll animals were euthanised and exhibited poor‐to‐emaciated body condition. Three OCSCCs arose from the maxillary oral mucosa and a single OCSCC was primarily mandibular, with bone invasion evident in three cases. Histologically, one OCSCC in situ was diagnosed, whilst the rest were typically invasive OCSCCs. Neoplastic cells were immunopositive for pancytokeratin and E‐cadherin. All examined cases were negative for regional lymph node (RLN) and/or distant metastases, cyclooxygenase‐2 (COX‐2) immunoexpression, and panherpesvirus PCR expression.ConclusionsOCSCCs in Goeldi's monkeys may be deeply invasive, but not readily metastatic. No herpesvirus‐association or COX‐2 expression was evident; the latter suggesting that NSAIDs are unlikely to be a viable chemotherapeutic treatment.

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“…Spontaneous neoplasms of capuchin monkeys have been only rarely reported (Cameron and Conroy, 1976;Brown et al, 1980;Grana et al, 1992;Klinger et al, 1993;Kramer and Bielitzki, 2012) and are mainly squamous cells carcinomas in the oral cavity or haired skin.…”

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confidence: 99%