Oral side effects of COVID‐19 vaccines in 32 European countries: Analysis of EudraVigilance reports

Riad, Abanoub; Schulz‐Weidner, Nelly; Dziedzic, Arkadiusz; Howaldt, Hans‐Peter; Attia, Sameh

doi:10.1002/jmv.28771

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…85 The allergic reaction could also lead to swollen lips, tongue, and mouth. 86,87 A summary of orofacial adverse reactions following COVID-19…”

Section: Other Adverse Reactionsmentioning

confidence: 99%

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A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID‐19 vaccination: The good, the bad, and the ugly

Najary,

Vatankhah,

Khadivi

et al. 2024

Health Science Reports

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Background and AimsAnti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines have the potential to alter several biological systems concurrently with remolding the immune system, most of which are related to immunization, while some others are known as adverse effects. This review aims to explore the potential effects of vaccination on the oral microenvironment and classifies them as good, bad, or ugly, with a brief review of facial diseases following coronavirus disease 2019 (COVID‐19) vaccination.MethodsThis study was a comprehensive review conducted through searching related articles in Medline, Scopus, and Google Scholar databases.ResultsOn one side, the “Good” impacts of vaccination on the oro‐nasal mucosa are explained as if the mucosal immune responses followed by SARS‐CoV‐2 vaccines are enough to provide immunity. On the other side, the possible “Bad” and “Ugly” effects of the vaccine, which manifest as orofacial adverse events and autoimmune reactivations, respectively, should be noted. Exacerbation of pre‐existing autoimmune conditions such as lichen planus, pemphigus vulgaris, bullous pemphigoid, and Stevens‐Johnson syndrome have been reported.ConclusionCOVID‐19 vaccines could affect different biological systems alongside stimulating the immune system, and some of these effects are referred to as adverse effects. Nonetheless, these adverse effects are treatable, and healthcare professionals should not prevent patients from taking the first available vaccination.

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“…85 The allergic reaction could also lead to swollen lips, tongue, and mouth. 86,87 A summary of orofacial adverse reactions following COVID-19…”

Section: Other Adverse Reactionsmentioning

confidence: 99%

“…The allergic reactions might also be induced by ingredients of the vaccine, such as polysorbate 80 and polyethylene glycol (PEG), which makes skin or intradermal injection testing mandatory before administration 85 . The allergic reaction could also lead to swollen lips, tongue, and mouth 86,87 …”

Section: The Badmentioning

confidence: 99%

A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID‐19 vaccination: The good, the bad, and the ugly

Najary,

Vatankhah,

Khadivi

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…While a widespread vaccination campaign is essential to fight against infectious diseases, it alone is not sufficient as a public policy to mitigate the adverse effects of the COVID-19 pandemic crisis [13], [19]. Cases have shown that COVID-19 vaccines can trigger adverse events in multiple systems, including oral, digestive, hematological, immune, and nervous systems [20], [21], [22], [23], [24], [25], [26]. Common side effects include tenderness at the injection site, fever, fatigue, body aches, and headaches [27], [28], [29], [30].…”

Section: Introductionmentioning

confidence: 99%

Adverse Events of COVID-19 Vaccines in the United States: Temporal and Spatial Analysis

Li,

Dang

et al. 2024

JMIR Public Health Surveill

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Background: COVID-19, a highly contagious respiratory disease, has rapidly emerged as a global pandemic. By 3 March 2024, 103.4 million confirmed cases of COVID-19 had been reported in the United States. Vaccination against COVID-19 is currently considered one of the most effective strategies to control its spread. However, due to variations in populations and the ongoing development of vaccines, it is expected that a certain number of individuals may experience adverse events following immunization (AEFI) for COVID-19 vaccines.Objective: In this study, we exclusively examined AEFI associated with COVID-19 vaccination reported by vaccine recipients. Our objective was to analyze the temporal and spatial characteristics of these reported AEFI to gain insights into their patterns and distribution. Methods:We analyzed the administration data from the Centers for Disease Control and Prevention (CDC) (N = 663,822,575) and the reports from the surveillance system-Vaccine Adverse Event Reporting System (VAERS) (N = 900,522) between 2020 and 2022. To gain a broader understanding of reported post-vaccination AEFI, we categorized them into System Organ Classes (SOCs) according to the Medical Dictionary for Regulatory Activities (MedDRA). Additionally, temporal analysis was conducted to examine the trends of AEFI in all VAERS reports, those related to Pfizer and Moderna as well as the Top 10 AEFI trends in serious reports. We also compared the similarity of symptoms across various regions within the United States.Results: Our findings revealed that the most frequently reported symptoms following COVID-19 vaccination were headache (N = 141,186), pyrexia (N = 122,120), and fatigue (N = 121,910). The most common symptom combination was chills and pyrexia (N = 56,954). Initially, General disorders and administration site conditions (SOC 22) were the most prevalent class reported. Moderna exhibited a higher reporting rate of AEFI compared to Pfizer. Over time, we observed a decreasing reporting rate for COVID-19-related AEFI. And the overall rates of AEFI between the Pfizer and Moderna vaccines were comparable. In terms of spatial analysis, the middle and north regions displayed a higher reporting rate of AEFI for COVID-19 vaccines, while the southeast and south central regions showed notable similarity in reported COVID-19 symptoms. Conclusions:This study presents a potentially beneficial method for AEFI surveillance, especially for severe cases, which can intensify research efforts in areas where abnormal or severe presentations occur. The findings suggest that increasing vaccination coverage reduces the reported AEFI, thereby enhancing vaccine confidence. Our study highlights the importance of robust health policies for managing AEFI in future vaccination campaigns. Specifically, health authorities should consider implementing targeted monitoring programs to detect and manage AEFI early, especially for symptoms that were severe and frequently reported in our analysis. These programs can help improve public confidence in COVID-...

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Oral adverse events following COVID-19 and influenza vaccination in Australia

Riad,

Issa,

Attia

et al. 2023

Human Vaccines & Immunotherapeutics

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Oral side effects of COVID‐19 vaccines in 32 European countries: Analysis of EudraVigilance reports

Cited by 3 publications

References 36 publications

A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID‐19 vaccination: The good, the bad, and the ugly

A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID‐19 vaccination: The good, the bad, and the ugly

Adverse Events of COVID-19 Vaccines in the United States: Temporal and Spatial Analysis

Oral adverse events following COVID-19 and influenza vaccination in Australia

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