Oral shedding of Bartonella in cats: Correlation with bacteremia and seropositivity

Namekata, David Y.; Kasten, Rickie W.; Boman, Dawn A.; Straub, Mary H.; Siperstein-Cook, Laurie; Couvelaire, Karen; Chomel, Bruno B

doi:10.1016/j.vetmic.2010.05.034

Cited by 17 publications

(16 citation statements)

References 25 publications

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“…In the present study, 39.9% of cats tested positive for Bartonella DNA, which is higher than those found in previous reports, including those that address cats from shelters. 13,15,[24][25][26] Similar results were reported in California, United States. 26 Notably, it was found that 97.3% of cats harbored bacterial DNA in a shelter in Volta Redonda municipality, Rio de Janeiro, which is attributable to local conditions.…”

Section: Discussionsupporting

confidence: 84%

“…13,15,[24][25][26] Similar results were reported in California, United States. 26 Notably, it was found that 97.3% of cats harbored bacterial DNA in a shelter in Volta Redonda municipality, Rio de Janeiro, which is attributable to local conditions. 27 Bartonella infection was significantly higher in cats from group 2 when than in those from group 1 (Rio de Janeiro municipality), which may be explained by differences in hygiene conditions and preventive flea control applied in these shelters.…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

Molecular Survey of Bartonella Species in Shelter Cats in Rio De Janeiro: Clinical, Hematological, and Risk Factors

Raimundo

Guimarães

Amaro

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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The present study aimed to detect Bartonella DNA in cats belonging to shelters, and to evaluate risk factors, clinical signs, and hematological abnormalities associated with infection. Complete blood counts and screening for the presence of Bartonella DNA were performed on cats' ethylenediamine tetraacetic acid anticoagulant-blood samples. Eighty-three cats (39.9%) were positive for Bartonella species. Bartonella DNA was also detected in fleas and in the blood of cats infested by positive flea. Cats that had not been sterilized, had outdoor access, had histories of fights, and had concurrent flea infestation were more likely to be infected by Bartonella species (P < 0.05). Age and sex were not associated with infection. Fifty-one (38.6%) symptomatic cats were positive to Bartonella species (P > 0.05). Clinical conditions most commonly observed were signs of respiratory abnormality and Sporothrix species coinfection (P > 0.05). Regarding hematological changes, eosinophilia was associated with infection (P < 0.05). A high frequency of Bartonella species infection was found in shelter cats and highlights the importance of adequate flea-control programs to prevent infection in cats and consequently in adopters and other animals.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 84%

Molecular Survey of Bartonella Species in Shelter Cats in Rio De Janeiro: Clinical, Hematological, and Risk Factors

Raimundo

Guimarães

Amaro

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…The route of infection is unknown, although direct conjunctival inoculation, most likely with infected flea feces, seems to be most plausible [149]. Knowing, however, that B. henselae is present in up to 40% of cat saliva [150], it is more plausible that salivary fluid could be rubbed directly into the eye from the skin after been licked by a cat. There are several anecdotal reports of infections in mainly young children that were transmitted by being licked.…”

Section: Licking the Facementioning

confidence: 99%

A One Health Perspective on the Human–Companion Animal Relationship with Emphasis on Zoonotic Aspects

Overgaauw

Vinke

Hagen

et al. 2020

IJERPH

149

137

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Over time the human–animal bond has been changed. For instance, the role of pets has changed from work animals (protecting houses, catching mice) to animals with a social function, giving companionship. Pets can be important for the physical and mental health of their owners but may also transmit zoonotic infections. The One Health initiative is a worldwide strategy for expanding collaborations in all aspects of health care for humans, animals, and the environment. However, in One Health communications the role of particularly dogs and cats is often underestimated. Objective: Evaluation of positive and negative One Health issues of the human–companion animal relationship with a focus on zoonotic aspects of cats and dogs in industrialized countries. Method: Literature review. Results: Pets undoubtedly have a positive effect on human health, while owners are increasing aware of pet’s health and welfare. The changing attitude of humans with regard to pets and their environment can also lead to negative effects such as changes in feeding practices, extreme breeding, and behavioral problems, and anthropozoonoses. For the human, there may be a higher risk of the transmission of zoonotic infections due to trends such as sleeping with pets, allowing pets to lick the face or wounds, bite accidents, keeping exotic animals, the importation of rescue dogs, and soil contact. Conclusions: One Health issues need frequently re-evaluated as the close human–animal relationship with pet animals can totally differ compared to decennia ago. Because of the changed human–companion animal bond, recommendations regarding responsible pet-ownership, including normal hygienic practices, responsible breeding, feeding, housing, and mental and physical challenges conforming the biology of the animal are required. Education can be performed by vets and physicians as part of the One Health concept.

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“…However, direct transmission between mammal hosts has occasionally been reported, e.g., via cat bites (57), and the release of Bartonella into the saliva of infected cats has been demonstrated (311).…”

Section: Host Specificitymentioning

confidence: 99%

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

2012

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SUMMARY Bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection strategy comprising immune evasion and modulation, intimate interaction with nucleated cells, and intraerythrocytic persistence. Infections with Bartonella are ubiquitous among mammals, and many species can infect humans either as their natural host or incidentally as zoonotic pathogens. Upon inoculation into a naive host, the bartonellae first colonize a primary niche that is widely accepted to involve the manipulation of nucleated host cells, e.g., in the microvasculature. Consistently, in vitro research showed that Bartonella harbors an ample arsenal of virulence factors to modulate the response of such cells, gain entrance, and establish an intracellular niche. Subsequently, the bacteria are seeded into the bloodstream where they invade erythrocytes and give rise to a typically asymptomatic intraerythrocytic bacteremia. While this course of infection is characteristic for natural hosts, zoonotic infections or the infection of immunocompromised patients may alter the path of Bartonella and result in considerable morbidity. In this review we compile current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella and discuss their connection to the clinical presentation of human patients, which ranges from minor complaints to life-threatening disease.

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Oral shedding of Bartonella in cats: Correlation with bacteremia and seropositivity

Cited by 17 publications

References 25 publications

Molecular Survey of Bartonella Species in Shelter Cats in Rio De Janeiro: Clinical, Hematological, and Risk Factors

Molecular Survey of Bartonella Species in Shelter Cats in Rio De Janeiro: Clinical, Hematological, and Risk Factors

A One Health Perspective on the Human–Companion Animal Relationship with Emphasis on Zoonotic Aspects

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

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