Oral Self-Administration and the Relevance of Conditioned Taste Aversions

Stolerman, Ian P.; D'Mello, G.D.

doi:10.1016/b978-0-12-004703-1.50016-4

Cited by 51 publications

(20 citation statements)

References 101 publications

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“…This e¤ect has been interpreted as a result of aversive post-ingestional e¤ects of the drug (Stolerman et al 1971). Indeed, several studies have shown that d-amphetamine and related compounds can produce both unconditioned and conditioned taste aversion (Sanger et al 1974;Booth et al 1977;Stolerman and DMello 1981;Lin et al 1993). Thus, the decline in voluntary intake of d-amphetamine might be due to a developing conditioned or unconditioned taste aversion produced by the drug.…”

Section: Discussionmentioning

confidence: 95%

The development of addiction to d -amphetamine in an animal model: same principles as for alcohol and opiate

Heyne¹,

Wolffgramm²

1998

Psychopharmacology

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We have established a rat model that reflects the course of development of alcohol and opiate addiction. The present study with d-amphetamine aimed to define general principles in the development of an addiction. Male rats had a continuous free choice between d-amphetamine solutions (100, 200 and 400 mg/l) and water for 47 weeks. An initial intake of high doses of d-amphetamine during the first weeks of drug choice was followed by an individually stable pattern of drug consumption of moderate drug doses. During this period of controlled consumption (from week 10 to week 40), the voluntary intake of d-amphetamine depended on individual factors (dominant rats: 0.37+/-0.02 mg/kg per day, subordinate rats: 0.57+/-0.05 mg/kg per day) and environmental variables (group housing: 0.21+/-0.02 mg/kg per day, single housing: 0.41+/-0.03 mg/kg per day). Beginning with week 41, voluntary d-amphetamine consumption progressively increased (1.9+/-0.2 mg/kg per day in week 47), although the experimental conditions remained unchanged. Drug intake during a retest (free choice as before) after 6 months of drug deprivation revealed that the rats had persistently lost their control over drug intake and were no longer able to adjust drug taking to internal and external conditions. These addicted rats took very high drug doses, even when all d-amphetamine solutions but not water were adulterated with bitter tasting quinine (6.6+/-0.6 mg/kg per day; age-matched controls: 0.37+/-0.04 mg/kg per day). Forced intake of d-amphetamine for 47 weeks (7.1+/-0.3 mg/kg per day) via the drinking fluid caused physical dependence (hyperreactivity during withdrawal) but did not lead to drug addiction (voluntary intake in the retest with adulteration: 0.42+/-0.04 mg/kg per day). Both the temporal development and the prerequisites of psychostimulant addiction were in principle the same as for alcohol and opiates.

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Section: Discussionmentioning

confidence: 95%

The development of addiction to d -amphetamine in an animal model: same principles as for alcohol and opiate

Heyne¹,

Wolffgramm²

1998

Psychopharmacology

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“…A threshold dose of nicotine induced CTAs in three groups pre-treated with bupropion, but these did not vary from the control group. The interpretation of conditioned taste aversions produced by psychoactive drugs is controversial because such effects may reflect positive conditioned suppression and may be more closely related to the rewarding than to the aversive properties of the substance (Stolerman and D'Mello 1981;Grigson 1997).…”

Section: Discussionmentioning

confidence: 99%

Investigating the actions of bupropion on dependence-related effects of nicotine in rats

2003

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“…MDPV has been shown to have both aversive and rewarding effects (King et al , 2014, 2015, Merluzzi et al , 2014), and in order to determine how these affective properties contribute to MDPV’s relative abuse potential, it is critical to examine factors that might influence the balance between them (Gaiardi et al , 1991, Riley, 2011, Stolerman and D’Mello, 1981, Verendeev and Riley, 2013). Sex is of particular interest here, because while the data regarding the influence of sex on avoidance and reward are mixed (see above), work with a number of stimulants has demonstrated that, in general, females may be more likely to abuse these drugs (Lynch et al , 2002, Russo et al , 2003, Zakharova et al , 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Given that drug self-administration is often described as the result of a balance between the aversive and rewarding effects of a drug (see Riley, 2011, Stolerman and D’Mello, 1981, Verendeev and Riley, 2013), it is important to examine each of these effects in order to determine any factors that may influence them and, thus, their impact on abuse. In one such examination of the aversive effects of MDPV, Merluzzi et al (2014) used a range of doses (1, 1.8 and 3.2 mg/kg) to assess taste avoidance conditioning in male Sprague-Dawley rats.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences

King

Wakeford

Taylor

et al. 2015

Pharmacology Biochemistry and Behavior

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Synthetic cathinones, otherwise known as “bath salts”, have gained significant attention in the last few years as a result of increased use and abuse. One such compound, 3,4-methylenedioxypyrovalerone (MDPV), is pharmacologically and behaviorally similar to cocaine and has been shown to possess both aversive and rewarding effects. For a host of other drugs, each of these effects (and their relative balance) can be influenced by a variety of factors, including sex, which in turn impacts drug taking behavior. In this context, the present assessment sought to determine whether males and females differed in MDPV-induced CTA and CPP. Both male and female Sprague-Dawley rats underwent a combined CTA/CPP procedure, in which an injection of one of three doses of MDPV (1.0, 1.8 or 3.2 mg/kg) was paired with both a novel saccharin solution and a novel environment and changes in preferences for these stimuli were examined. Taste avoidance was evident in both sexes, although this avoidance was weaker in females compared to males. MDPV also produced place preferences in all drug-treated animals, but these preferences did not vary as a function of sex. The fact that females showed a weaker avoidance response compared to males (despite comparable preferences) suggests that females may have a heightened susceptibility to use and abuse of MDPV, paralleling results seen with cocaine and other stimulants. The present findings extend the behavioral characterization of MDPV and the factors that may alter its aversive and rewarding effects.

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Oral Self-Administration and the Relevance of Conditioned Taste Aversions

Cited by 51 publications

References 101 publications

The development of addiction to d -amphetamine in an animal model: same principles as for alcohol and opiate

The development of addiction to d -amphetamine in an animal model: same principles as for alcohol and opiate

Investigating the actions of bupropion on dependence-related effects of nicotine in rats

Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences

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