Oral Rhabdomyosarcoma: A review

Tandon, Ankita; Sethi, Kanika; Singh, Annette

doi:10.4317/jced.50926

Cited by 22 publications

(38 citation statements)

References 22 publications

(55 reference statements)

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“…with the former showing local destructive growth. 13,16 Squamous cell carcinomas and their rarer spindle cell variants, sarcomatoid carcinomas, are the most frequent overall and spindle cell malignancies in the oral cavity, respectively. 10,11,17 As such, all other malignant lesions with a spindle cell morphology were excluded in the present case due to their rare occurrence at this site.…”

Section: Discussionmentioning

confidence: 99%

“…10 Other malignancies with spindle cell morphology include squamous cell carcinomas, gastrointestinal stromal tumours, fibrosarcomas, myofibroblastic sarcomas, melanomas, rhabdomyosarcomas and spindle cell myoepithelial carcinomas. [11][12][13][14][15][16][17] In particular, myofibroblastic sarcomas and rhabdomyosarcomas also affect younger individuals, proteins. The final diagnosis was of a well-differentiated grade I LMS.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Besides early diagnosis, the prognosis of oral LMS patients depends on the tumour grade, size, site and treatment. [20][21][22] Currently, there are no standard criteria for therapy, although the complete excision of the tumour with wide surgical margins is recommended.…”

Section: Discussionmentioning

confidence: 99%

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Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Viviano

Miracco

Lorenzini

et al. 2018

Sultan Qaboos Univ Med J

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Leiomyosarcoma (LMS) is a rare mesenchymal malignancy, of which 3-10% of cases occur in the head and neck region. We report a 22-year-old woman who was referred to the University Hospital of Siena, Italy, in 2016 with an ostensibly benign asymptomatic lump on the mandibular gingiva. The lesion grew rapidly, causing otalgia in the right ear. An excisional biopsy was performed and primary LMS was diagnosed histologically. Subsequently, the patient underwent radical re-excision of the perilesional mucosa, a partial bone resection and the extraction of four teeth. No recurrences or metastases were detectable at a 20-month follow-up. This report discusses the differential diagnosis of LMS with regards to other benign and malignant lesions and reviews the recent literature on primary and secondary oral LMS. Due to its innocuous clinical features-including its asymptomatic nature and presentation at a young age-this aggressive malignancy can go undetected; therefore, an early histopathological diagnosis is crucial.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Viviano

Miracco

Lorenzini

et al. 2018

Sultan Qaboos Univ Med J

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“…[1] It shows a characteristic age distribution, most of the patients being within the second decade of life. RMSs are associated with a high rate of recurrence; an aggressive neoplastic behavior characterized by highly invasive, immature cells, and generalized metastasis through hematogenic and/or lymphatic routes.…”

Section: Introductionmentioning

confidence: 99%

Spindle cell embryonal rhabdomyosarcoma mimicking innocuous lesion – A case report

Kumar¹,

Suman²,

Vijaylakshmi³

et al. 2017

JMRPS

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Rhabdomyosarcomas (RMSs) are rare malignant neoplasms that originate from the embryonal cells called rhabdomyoblasts. Hence, they tend to be much more common in children, although rarely occurring in adults. A 19-year-old adult female patient reported with a complaint of painful growth in the lower anterior jaw. The patient gave a history of growth in the lower anterior labial vestibule 2 months ago which was insidious in onset and was first noticed 2 months ago for which patient had visited a private dental hospital where it was excised, records of which were not traceable. The clinical features with radiological, histopathological, and immunohistochemical findings confirmed the diagnosis of spindle cell embryonal RMS (ERMS) which are discussed in this paper in detail. Early diagnosis plays a pivotal role in the prognosis of spindle cell ERMS which is a fatal, rapidly proliferating, and malignant neoplasm. A thorough knowledge of the pathognomonic presentation of RMS can aid in differentiating from various innocuous soft tissue growths. Hence, the oral physician plays a key role in prompt diagnosis of such lesions which ensures better prognosis.

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“…3 The clinical presentation varies with the anatomic site, usually presenting as painless and rapidly growing mass. 4,5 They are classified histologically to embryonal, alveolar, botryoid, and pleomorphic. It tends to occur in three regions were the head and neck, upper and lower extremities, and genitourinary tract.…”

Section: Introductionmentioning

confidence: 99%

Retromolar Embryonal Rhabdomyosarcoma: A Case Report

Johanna

Setiawan

2017

JBN

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Background: embryonal rhabdomyosarcoma is common of rhabdomyosarcoma, usually in 5 years old child. Approximately 28% of embryonal rhabdomyosarcomas occur in head and neck area, and 0.04% of cases occur as intra-oral tumors. Case: a 13 years old female complained of a firm and painless progressive mass in her right mandibular retromolar 6 months prior to her current medical check-up. There was a reddish 8x5 cm mass on the right posterior mandibular region. Mid face CT scan showed a well-bordered solid mass in her right oral cavity expanding to the right maxilla without bone destruction nor intracranial expansion. Incisional biopsy concluded the morphology as an embryonal rhabdomyosarcoma. Four series of neoadjuvant chemotherapy of vincristine, adriamycin, and cyclophosphamide (VAC) regimen gave partial response clinically and was followed by right marginal mandibulectomy procedure. Histopathological surgical specimen examination showed no active cancer cells. Adjuvant chemotherapy was given afterward. The result is good cosmetically and functionally. Discussion: retromolar embryonal rhabdomyosarcoma is diagnosed by physical examination of progressive and firm retromolar mass, retromolar mass with or without nearby-structures invasion radiologically, and confirmed by histopathology examination. Neoadjuvant chemotherapy showed partial response clinically. Complete tumor resection with adequate surgical margin is the key for a successful therapy. Conclusion: embryonal rhabdomyosarcoma is rare. The treatment plan and outcome are unique in every patient depending on the location of the tumor, the histological type, and the respectability. Pathological examination and CT scan play a significant role in diagnosing and making a good surgical plan. Early diagnosis and complete resection with adequate surgical margin is the key for a successful therapy.

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Oral Rhabdomyosarcoma: A review

Cited by 22 publications

References 22 publications

Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Spindle cell embryonal rhabdomyosarcoma mimicking innocuous lesion – A case report

Retromolar Embryonal Rhabdomyosarcoma: A Case Report

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