Oral rehydration solutions in watery diarrhea in children: what’s new?

Захарова, И. Н.; Berezhnaya, I. V.; Kamilova, A.T.; Дедикова, О. В.

doi:10.21518/2079-701x-2020-10-34-40

Cited by 2 publications

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References 19 publications

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“…Во всем мире диарея является одной из ведущих причин смерти в педиатрической популяции, особенно у детей в возрасте до 5 лет, несмотря на успехи, достигнутые в лечении этого заболевания [34,35]. Поиск эффективных способов терапии актуален и продолжается в настоящее время.…”

Section: влияние L Reuteri на течение острого гастроэнтеритаunclassified

Efficacy of Lactobacillus reuteri in clinical practice

Комарова¹

2021

Russian Journal of Woman and Child Health

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This paper addresses the primary aspects of developing gut microbiota and the immune system and the role of gut microbiocenosis in this process. Optimal gut colonization and adequate immune response are critical factors in developing tolerance to commensal microbes and anti-infectious protection. The authors highlight various prenatal, neonatal, and postnatal factors which prevent normal colonization of gastrointestinal mucosa. One of the methods to restore the qualitative and quantitative composition of gut microbiota are probiotics. Probiotics demonstrating antagonistic activity for pathogens compete with these pathogens for the adhesion to mucosal epithelium and nutrients, thereby inhibiting the production of bacterial toxins, modulating the functions of the immune system, improving gut microbiocenosis, maintaining the integrity of the gastrointestinal mucosal barrier, and controlling gut inflammation. Probiotics are a heterogeneous group of living bacteria with species- and strain-specific properties. For example, Lactobacillus reuteri is an effective probiotic commonly prescribed in premature babies, children with acute gastroenteritis, and infantile colic. KEYWORDS: gut microbiota, microbiocenosis, premature, C-section, probiotics, bacteria, immune system, infantile colic, Lactobacillus reuteri. FOR CITATION: Komarova O.N. Efficacy of Lactobacillus reuteri in clinical practice. Russian Journal of Woman and Child Health. 2021;4(3):277–283 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-277-283.

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Section: влияние L Reuteri на течение острого гастроэнтеритаunclassified

Efficacy of Lactobacillus reuteri in clinical practice

Комарова¹

2021

Russian Journal of Woman and Child Health

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Differential diagnosis of infectious watery diarrhea (view from time immemorial to the present). Modern approaches to rehydration

et al. 2021

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Today, as in ancient times, diarrhea (loss of water and electrolytes along with stool) accompanies many pathological conditions in humans. The pathophysiology of various types of diarrhea has been studied, which made it possible to optimize therapeutic approaches and save the lives of many people. The most dangerous conditions occur in young patients with osmotic and exudative types of diarrhea, as they result in exicosis within a short time. In arriving at a diagnosis, rehydration therapy should be started as soon as possible. The article presents the historical aspects associated with the global pandemics of cholera. The history of the creation of solutions for intravenous and oral rehydration is covered. The authors presented tables for calculating fluid losses and the required volume of solutions for oral or parenteral administration. The modern requirements for rehydration solutions and the principles of rehydration in children are presented. Oral rehydration is particularly problematic for young children due to the limited range of drugs and requirements for the composition of solutions used in pediatrics. According to the recommendations of the World Health Organization and ESPGHAN, clinical recommendations of the Russian Federation, low-osmolar solutions should be used. When complex solutions containing probiotic and zinc are used, the therapy compliance increases. A rehydration solution, which contains a weighted amount of salt for the preparation of a low-osmolar solution, as well as the probiotic L. reuteri DSM 17938 at least 1 billion of viable bacteria and zinc sulphate 0.004 g is one of the latest solutions. The results of studies of this solution are provided.

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Oral rehydration solutions in watery diarrhea in children: what’s new?

Cited by 2 publications

References 19 publications

Efficacy of Lactobacillus reuteri in clinical practice

Efficacy of Lactobacillus reuteri in clinical practice

Differential diagnosis of infectious watery diarrhea (view from time immemorial to the present). Modern approaches to rehydration

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