Oral rehydration formula containing alanine and glucose for treatment of diarrhoea: a controlled trial.

Patra, F. C.; Sack, David A.; Islam, Asma; Alam, A. N.; Mazumder, Ramendra Nath

doi:10.1136/bmj.298.6684.1353

Cited by 51 publications

(24 citation statements)

References 12 publications

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“…We believe, as do others [19][20][21][22], that there is an important need for an improved ORS that will not only rehydrate a child, but also provide more calories and nitrogen.…”

Section: Discussionmentioning

confidence: 83%

Composition and preliminary evaluation of a hydrolyzed rice-based oral rehydration solution for the treatment of acute diarrhea in children.

Lebenthal

Khin‐Maung‐U²,

Rolston³

et al. 1995

Journal of the American College of Nutrition

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“…We believe, as do others [19][20][21][22], that there is an important need for an improved ORS that will not only rehydrate a child, but also provide more calories and nitrogen.…”

Section: Discussionmentioning

confidence: 83%

Composition and preliminary evaluation of a hydrolyzed rice-based oral rehydration solution for the treatment of acute diarrhea in children.

Lebenthal

Khin‐Maung‐U²,

Rolston³

et al. 1995

Journal of the American College of Nutrition

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“…Additionally, these solutions may be tailored to this specific patient population and may include not only glucose but also certain amino acids such as alanine, glutamine, and arginine that have been shown to be trophic to the gut. 52,53 It is also possible to add soluble fiber to these solutions. In our own experience, we have used commercially prepared soluble fiber supplements and added these to the ORS solutions that the patients consume throughout the day.…”

Section: Zinc and Oral Rehydration Solutionsmentioning

confidence: 98%

Review of a Potential Role for Zinc Supplementation in Oral Rehydration Solutions

2003

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Patients with short bowel syndrome often present with diarrhea and significant fluid and electrolyte abnormalities. Management consists of the use of medication, dietary modification, and oral rehydration solutions. Zinc deficiency has been shown to result in diarrhea. Oral zinc has been used for the management of acute diarrhea primarily in underprivileged children in developing countries. The effectiveness and feasibility of adding zinc to oral rehydration solutions (ORS) to abate and control diarrhea for adult patients with intestinal failure caused by short bowel syndrome has not been studied. Based on studies evaluating the use of oral zinc supplementation in the treatment of acute diarrhea, recommendations are made for the composition of ORS in adults.

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“…The added liquid helps to prevent the preparation of hypertonic solutions. Studies have attempted to exploit the additive sodium absorption seen with neutral amino acids, such as alanine and glycine, without striking clinical benefit [36]. In addition, amylase-resistant maize starch-based ORT has been tested to provide colonic butyrate to reduce cholera diarrhea.…”

Section: New Research Pathways For Ortmentioning

confidence: 99%

Cholera, Diarrhea, and Oral Rehydration Therapy: Triumph and Indictment

Guerrant

Carneiro‐Filho

Dillingham

2003

Clinical Infectious Diseases

109

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Cholera drove the sanitary revolution in the industrialized world in the 19th century and now is driving the development of oral rehydration therapy (ORT) in the developing world. Despite the long history of cholera, only in the 1960s and 1970s was ORT fully developed. Scientists described this treatment after the discovery of the intact sodium-glucose intestinal cotransport in patients with cholera. This new understanding sparked clinical studies that revealed the ability of ORT to reduce the mortality associated with acute diarrheal disease. Despite the steady reductions in mortality due to acute dehydrating diarrheal diseases achieved by ORT, the costly morbidity due to these diseases remains, the result of a failure to globalize sanitation and to control the developmental impact of diarrheal diseases and their associated malnutrition. New advances in oral rehydration and nutrition therapy and new methods to recognize its costs are discussed in this review.

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Oral rehydration formula containing alanine and glucose for treatment of diarrhoea: a controlled trial.

Cited by 51 publications

References 12 publications

Composition and preliminary evaluation of a hydrolyzed rice-based oral rehydration solution for the treatment of acute diarrhea in children.

Composition and preliminary evaluation of a hydrolyzed rice-based oral rehydration solution for the treatment of acute diarrhea in children.

Review of a Potential Role for Zinc Supplementation in Oral Rehydration Solutions

Cholera, Diarrhea, and Oral Rehydration Therapy: Triumph and Indictment

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