Oral, radiographical, and clinical findings in Weaver syndrome: a case report

Abstract

Weaver syndrome is a rare condition characterized by accelerated growth, advanced osseous maturation, and distinct craniofacial features that can occur in both males and females. Etiology is unknown and no definitive oral characteristics have been established. The objective of this case report is to describe the oral and radiographic findings of a 14-year-old male with Weaver syndrome. A comprehensive dental examination was performed under general anesthesia. The clinical findings were: severe generalized heavy plaque with subgingival calculus, gingival edema, malocclusion and maxillary atresia, mild micrognathia of the mandible, enlarged tongue, and bifid uvula. Clinical and radiographic caries were not found. Out of over 40 possible cases of Weaver syndrome previously reported in the literature, only two were related to the oral cavity. Bifida uvula was not mentioned until now as clinical findings associated with the syndrome. Autism, macroglossia, and cleft palate were seldom mentioned. The oral manifestations in Weaver syndrome are not yet well known. Future studies will be required to improve the subject matter.

Posteromedial Hypothalamic Deep Brain Stimulation for Refractory Aggressiveness in a Patient With Weaver Syndrome: Clinical, Technical Report and Operative Video

“…4,17 About 80% of patients have intellectual disabilities, which are usually mild, and only in a few cases, moderate. 5,18,19 Among the psychological and behavioral aspects that are present in WS, to our knowledge this is the first case in which a severe and refractory aggressive and disruptive behavior is present. In the clinical review of 48 patients conducted by Tatton-Brown et al, 5 only 5 patients had some behavioural-related alterations: 2 patients with attention deficit and 3 with temper tantrums.…”