Oral pulsed high-dose dexamethasone therapy for rheumatic diseases: An alternative safe and effective scheme

Carvalho, Jozélio Freire de

doi:10.14744/nci.2023.03704

Cited by 1 publication

(2 citation statements)

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“…Dexamethasone, a glucocorticoid drug, is used to treat RA, and its antirheumatic potency is higher than any other steroid, about five to six times more than that of prednisolone. 9 These drugs act rapidly to treat swelling and pain. Disease-modifying antirheumatic drugs (DMARDs) such as hydroxychloroquine, methotrexate, and sulfasalazine are also used to treat RA.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The first-line therapy for the treatment of RA is drugs that suppress the inflammation such as nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids. Dexamethasone, a glucocorticoid drug, is used to treat RA, and its antirheumatic potency is higher than any other steroid, about five to six times more than that of prednisolone . These drugs act rapidly to treat swelling and pain.…”

Section: Introductionmentioning

confidence: 99%

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Rheumatoid Arthritis Treatment Potential of Stearic Acid Nanoparticles of Quercetin in Rats

Alotaibi,

Waqas,

Saleem

et al. 2024

ACS Omega

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This study aims to assess the anti-inflammatory potential of stearic acid nanoparticles of quercetin in an arthritic rat model. This article describes the fabrication of solid lipid nanoparticles (SLNs) using the hot melt encapsulation method, followed by the anti-inflammatory study of SLNs and other characterizations such as FTIR, XRD, and SEM. Thirty male healthy albino rats were taken and treated with FCA to induce rheumatoid arthritis. Quercetin loading of quercetin to stearic acid was confirmed by FTIR. The efficacy of quercetin-loaded SLNs to reduce inflammation was evaluated with the help of inflammatory biomarker levels. Quercetin-loaded stearic acid nanoparticles were successfully prepared by using a hot melt encapsulation method. Their average size and zeta potential were 100 nm and −25 mV, respectively. Rheumatoid arthritis was significantly (p < 0.001) reduced in the quercetin-loaded SLN group, as indicated by finding out the reduced levels of inflammatory mediators such as tumor necrosis factor (TNF-α) and rheumatoid factor. Quercetin-loaded stearic acid nanoparticles were found to be potentially effective in treating RA.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%