Oral protein-based supplements versus placebo or no treatment for people with chronic kidney disease requiring dialysis

Mah, Jia Yee; Choy, Suet Wan; Roberts, Matthew A; Desai, A.; Corken, Melissa; Gwini, Stella May; McMahon, Lawrence P.

doi:10.1002/14651858.cd012616.pub2

Cited by 26 publications

(45 citation statements)

References 78 publications

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“…Oral nutrition supplements are an efficient way to increase nutrition intake in patients who are not otherwise meeting their nutrition goals and are at risk for malnutrition [ 25 ]. Despite poor compliance with ISRNM nutrition guidelines, oral nutrition supplements were infrequently prescribed to people with or without OWOB.…”

Section: Discussionmentioning

confidence: 99%

Status of Nutrition in Hemodialysis Patients Survey (SNIPS): Nutrition Intake in Obese and Overweight vs. Healthy Weight Patients

Boaz

Azoulay

Weinstein

2021

Life

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Elevated body mass index (BMI) has been associated with improved survival and fewer hospitalizations in hemodialysis patients; however, it is not clear that dietary intake is associated with increased BMI in hemodialysis patients. The present analysis was designed to compare energy and macronutrient intake and distribution, as well as compliance with the International Society of Renal Nutrition and Metabolism (ISRNM) dietary guidelines, by body weight status (overweight/obese vs. normal weight) in hemodialysis patients. The status of nutrition in hemodialysis patients survey (SNIPS) cohort is a cross-sectional study including a representative sample of individuals on hemodialysis treated in hospital dialysis centers throughout Israel. Of the 375 patients eligible for the current analysis, 60.1% had BMI ≥ 25 kg/m2 (overweight/obese). For each participant, the following measures were recorded: dietary intake, blood biochemistry, anthropometric and hemodynamic measures. These were compared by body weight status. Compared to their normal-weight counterparts, overweight/obese hemodialysis patients did not differ by energy and macronutrient intake, distribution of these nutrients in the diet. Regardless of body weight status, hemodialysis patients have poor compliance with ISRNM dietary guidelines.

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Section: Discussionmentioning

confidence: 99%

Status of Nutrition in Hemodialysis Patients Survey (SNIPS): Nutrition Intake in Obese and Overweight vs. Healthy Weight Patients

Boaz

Azoulay

Weinstein

2021

Life

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“…Protein and energy intake should be always adjusted for gender, age, and levels of physical activity according to international indications [ 124 ], ensuring caloric supplementation during the dialysis session [ 125 ] or acute kidney injury [ 126 ]. Oral nutritional supplements, with no added phosphate, should be used for short periods to satisfy specific clinical needs, with a balanced composition of macronutrients tailored for patients’ necessities [ 127 , 128 ].…”

Section: Nutritional Intervention Against Inflammaging In Ckd/rrt mentioning

confidence: 99%

Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies

et al. 2021

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Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of conservative therapies for advanced CKD and the consequences of the uremic milieu, with a frail clinical condition that impacts not only their survival but also limits their access to transplantation. This process, referred to as “inflammaging,” might be reversible with a tailored approach, such as RRT accompanied by specific nutritional support. In this review, we summarize the evidence demonstrating the presence of several proinflammatory substances in the Western diet (WD) and the positive effect of unprocessed food consumption and increased fruit and vegetable intake, suggesting a new approach to reduce inflammaging with the improvement of ESRD clinical status. We conclude that the Mediterranean diet (MD), because of its modulative effects on microbiota and its anti-inflammaging properties, may be a cornerstone in a more precise nutritional support for patients on the waiting list for kidney transplantation.

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“…study participants, (6) sample size of the intervention and control groups, (7) age, (8) dialysis vintage, (9) nutritional status, (10) the intervention modality in the treatment group, (11) the frequency of interventions, (12) the intervention modality in the control group, (13) compliance with interventions, and 14outcome measures obtained ( Table 2).…”

Section: Data Extractionmentioning

confidence: 99%

“…The consensus from the International Society of Renal Nutritional and Metabolism states that nutritional supplementation is effective in replenishing protein and energy stores [3]. Systematic reviews have recently shown that protein or amino acid supplementation was associated with an improvement in nutritional status by resulting in an increase in serum albumin [11,12]. We hypothesize that interventions consisting of amino acid/protein supplementation can overcome the anabolic resistance of skeletal muscle tissue and attenuate or even prevent the accelerated loss of skeletal muscle mass and strength through nutritional status improvement in patients on hemodialysis as described in a recent systematic review of elderly individuals without renal disease [13].…”

Section: Introductionmentioning

confidence: 99%

The effects of amino acid/protein supplementation in hemodialysis patients: study protocol for a systematic review and meta-analysis

et al. 2020

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Background: Multiple factors including older age, comorbidities, inflammation, metabolic acidosis, dialysis-related hypercatabolism and anabolic resistance of skeletal muscle, extraction of circulating amino acids through hemodialysis and inadequate dietary protein intake due to anorexia, and strictly limited dietary phosphorus intake are likely to contribute to the high prevalence of malnutrition and metabolic abnormalities, more aptly called protein-energy wasting, in patients on hemodialysis. The consensus from the International Society of Renal Nutritional and Metabolism states that nutritional supplementation is effective for replenishing protein and energy stores. Although we hypothesize that amino acid/protein supplementation can overcome the anabolic resistance of skeletal muscle tissue and attenuate or even prevent the accelerated loss of skeletal muscle mass and strength through nutritional status improvement in patients on hemodialysis, whether amino acid and/or protein administration is associated with improvements in these outcomes is unknown. The main objective of this study is to systematically review the impact of amino acid/protein supplementation on skeletal muscle mass, muscle strength, physical function, and quality of life in end-stage renal disease patients requiring hemodialysis. Methods: Published randomized controlled trials (RCTs) assessing the effectiveness of amino acid/protein supplementation in hemodialysis patients with respect to body composition, muscle mass, muscle strength, physical function, and quality of life will be included. The bibliographic databases include MEDLINE, the Web of Science, the Cochrane Central Register of Controlled Trials, and Embase. The risk of bias of the included RCTs will be assessed using the Cochrane Collaboration's tool by two independent reviewers. The primary outcome will be skeletal muscle mass, muscle strength, and physical function, and the secondary outcome will be quality of life. This review protocol is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) 2015 checklist.

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Oral protein-based supplements versus placebo or no treatment for people with chronic kidney disease requiring dialysis

Cited by 26 publications

References 78 publications

Status of Nutrition in Hemodialysis Patients Survey (SNIPS): Nutrition Intake in Obese and Overweight vs. Healthy Weight Patients

Status of Nutrition in Hemodialysis Patients Survey (SNIPS): Nutrition Intake in Obese and Overweight vs. Healthy Weight Patients

Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies

The effects of amino acid/protein supplementation in hemodialysis patients: study protocol for a systematic review and meta-analysis

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