Oral Prophylaxis of Rheumatic Fever With Penicillin

Milzer, Albert; Kohn, Kate H.; MacLean, Helen E.

doi:10.1001/jama.1948.02890250024005

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1948

1952

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Cited by 19 publications

(1 citation statement)

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“…The subject has been discussed by Lapin3 as well as Milzer and others. 7 Milzer believed that such resis¬ tance could be overcome by increasing the size of the prophylactic dose. Lapin found no evidence that resis¬ tance developed.…”

mentioning

confidence: 98%

Mass Penicillin Prophylaxis

Kuh¹

1949

JAMA

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mentioning

confidence: 98%

Mass Penicillin Prophylaxis

Kuh¹

1949

JAMA

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Infectious Diseases

Reimann¹

1948

Arch Intern Med (Chic)

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Cardiovascular Diseases

Schaaf¹

1950

Arch Intern Med (Chic)

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It has been hypothesized that Helicobacter pylori (Hp) infection may contribute to reduced stature, risk of hypertension or obesity. The aim was to evaluate body indices in Hp positive and negative persons. A total of 2436 subjects (4-100 years old) were tested for Hp status by 13 C-urea breath test. Data on height and weight were collected for 84%, and blood pressure for 80% of the study subjects. The prevalence of Hp infection was 41.6%. The odds ratio for a 10-year increase in age was 1.21 (95% CI 1.17-1.25, p-value <0.001). Statistically significant negative association of Hp positivity with body height was most pronounced in the younger age groups, while a positive association of Hp positivity with body mass index was only seen in those aged 15+ years. There was a negative effect of Hp positivity on systolic and diastolic blood pressure in subjects below 25 and a relatively strong positive effect on blood pressure in subjects over 65 years. Residual confounding by social characteristics as a possible explanation for the associations of Hp positivity with height and blood pressure cannot be excluded. Unmeasured factors related to social and family environment may cause the apparent association between Hp positivity and children's growth and blood pressure.

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Oral Prophylaxis of Rheumatic Fever With Penicillin

Cited by 19 publications

References 8 publications

Mass Penicillin Prophylaxis

Mass Penicillin Prophylaxis

Infectious Diseases

Cardiovascular Diseases

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