Abstract:Galectin-3 (gal-3) has an important role in the inflammatory process, demonstrated by the fact that gal-3 deficient mice (gal3-/-) show decreased recruitment of inflammatory leukocytes in a peritonitis model. In addition, gal-3 is a powerful attractant of monocytes and macrophages. Since leukocyte migration stimulated by lectins was shown to be done through haptotaxis, we investigated if a such mechanism accounts for the human monocyte migration induced by gal-3, as well the participation of components of the … Show more
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